Pomegranate juice prevents development of non‐alcoholic fatty liver disease in rats by attenuating oxidative stress and inflammation

Noori, Maryam; Jafari, Bahar; Hekmatdoost, Azita

doi:10.1002/jsfa.8042

Cited by 47 publications

(39 citation statements)

References 25 publications

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“…Over the last decade, different parts of pomegranate extracts have been shown to prevent the pathological development of NAFLD associated with the regulation of hepatic lipid metabolism . Panchal et al reported that diets supplemented with 0.08% ellagic acid for 8 weeks improved NAFLD and plasma lipid profiles in HFD‐induced Wistar rats.…”

Section: Effects Of Pomegranate On Nafldmentioning

confidence: 99%

“…Reduce serum levels of TC, TG, LDL-C, VLDL-C, and hepatic steatosis [17] 60 ± 5 mL day −1 7 weeks Rats fed a high-fat/sugar diet Reduce hepatic steatosis level Reduce plasma TG level [80] 500 mL day −1 1 week Healthy humans Reduce plasma MDA level [92] 250 mL day −1 12 weeks T2DM patients Reduce plasma MDA level [93] that regulate lipid metabolism in metabolic disorder associated diseases.…”

Section: Days Stz-induced Diabetic Ratsmentioning

confidence: 99%

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Beneficial Effects of Pomegranate on Lipid Metabolism in Metabolic Disorders

Hou

Zhang

et al. 2019

Molecular Nutrition Food Res

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Pomegranate (Punica granatum Linn) is used in the prevention and treatment of metabolic syndrome in recent decades. Imbalances in lipid metabolism are profound features of metabolic disorders. In vivo and in vitro studies have shown that extracts of different pomegranate fractions (peels, flowers, juice, and seeds) regulate lipid metabolism in metabolic‐disorder‐associated diseases such as atherosclerosis, nonalcoholic fatty liver disease, and type 2 diabetes, helping to alleviate the development of diseases. Amelioration of oxidative stress and the inflammatory response is considered an important reason underlying the regulation of lipid metabolism by pomegranate extracts. Mitochondria, the major cellular site for lipid oxidation, are strongly associated with cellular oxidative and inflammatory status and are likely to be a target for pomegranate extract action. This review summarizes the main findings about the effects of different pomegranate fraction extracts on lipid metabolism in metabolic‐disorder‐associated diseases and analyses how pomegranate extracts achieve their effects. Furthermore, it also provides an important basis for the research and development of pomegranate‐related nutrients or drugs.

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Section: Effects Of Pomegranate On Nafldmentioning

confidence: 99%

Section: Days Stz-induced Diabetic Ratsmentioning

confidence: 99%

Beneficial Effects of Pomegranate on Lipid Metabolism in Metabolic Disorders

Hou

Zhang

et al. 2019

Molecular Nutrition Food Res

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“…The pathogenesis of NAFLD is associated with metabolic diseases such as diabetes mellitus, hyperlipidemia, and obesity, which are also the main risk factors of cardiovascular disorders (Cicero, Colletti, & Bellentani, ; Patti et al, ). Currently, there is no approved treatment for NAFLD although health promotion strategies and lifestyle modifications are recommended as the primary steps in disease management (Emamat et al, ; Hekmatdoost et al, ; Mokhtari, Poustchi, Eslamparast, & Hekmatdoost, ; Noori, Jafari, & Hekmatdoost, ; Rahimlou, Ahmadnia, & Hekmatdoost, ; Rahimlou, Yari, Hekmatdoost, Alavian, & Keshavarz, ). Over the past few years, numerous studies have been conducted to find plant‐based biological compounds for treatment of NAFLD (Bahrami et al, ; Mofidi et al, ; Saadati et al, ).…”

Section: Introductionmentioning

confidence: 99%

The effects of black seed supplementation on cardiovascular risk factors in patients with nonalcoholic fatty liver disease: A randomized, double‐blind, placebo‐controlled clinical trial

Darand

Darabi

Yari

et al. 2019

Phytotherapy Research

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Nonalcoholic fatty liver disease (NAFLD) is highly related to cardiovascular disorders risk factors. This study aimed to evaluate the effects of black seed (Nigella sativa) supplementation on cardiovascular disorders risk factors in patients with NAFLD. This randomized, double‐blind, placebo‐controlled clinical trial was conducted on 50 patients with NAFLD. Participants were assigned to receive a lifestyle modification plus 2 g/day of either N. sativa or placebo for 12 weeks. Compared with the placebo, N. sativa supplementation led to significant reductions in serum glucose (−7.95 vs. −1.22; p = .041), serum insulin (−3.87 vs. −1.07; p = .027), homeostatic model of assessment for insulin resistance (−1.02 vs. −0.28; p = .021), and a significant increase in quantitative insulin sensitivity check index (0.03 vs. 0.006; p = .002). All of these changes were remained significant after adjusting for known confounding variables; however, there was no significant difference in lipid profile changes between the two groups (p = .05). N. sativa supplementation significantly decreased hepatic steatosis percentage compared with the placebo after adjustment for confounding variables (p = .005). In conclusion, our results indicate that daily intake of 2‐g N. sativa plus lifestyle modification is superior to lifestyle modification alone in amelioration of insulin resistance and hepatic steatosis in patients with NAFLD.

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“…The earliest stage of NAFLD is hepatic steatosis, characterized by accumulation of TAG in hepatocytes without signs of inflammation and hepatocellular damage (Haas et al, ). Recent reports demonstrated that consumption of PJ or pomegranate extract decreases high‐fat diet‐induced hepatic steatosis by promoting mitochondrial function, as well as by eliminating oxidative stress and inflammation (Noori et al, ; Zou et al, ). In line with the above reports, we found that the PJ consumption significantly decreased the hepatic TAG content in mice.…”

Section: Discussionmentioning

confidence: 99%

Exogenous (Pomegranate Juice) or Endogenous (Paraoxonase1) Antioxidants Decrease Triacylglycerol Accumulation in Mouse Cardiovascular Disease‐Related Tissues

Rom

Volkova

Jeries

et al. 2018

Lipids

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The polyphenol‐rich pomegranate juice (PJ) and the high‐density lipoprotein (HDL)‐associated paraoxonase1 (PON1) are known as potent atheroprotective antioxidants, but their effects on other tissues related to cardiovascular disease (CVD) remain unknown. The current study aimed to investigate the effects of treating mice with PJ or recombinant PON1 (rePON1) on the oxidation and lipid status of CVD‐related tissues: serum, aorta, heart, liver, kidney, visceral, and subcutaneous adipose tissues (VAT and SAT). Both PJ consumption and rePON1 injection decreased the serum levels of thiobarbituric acid‐reactive substances (16% and 19%) and triacylglycerols (TAG, 24% and 27%), while only rePON1 increased the levels of thiol groups (35%) and decreased serum cholesterol (15%). Both PJ and rePON1 significantly decreased aortic cholesterol (38% and 32%) and TAG (62% and 58%) contents in association with downregulation of the key TAG biosynthetic enzyme diacylglycerol O‐acyltransferase 1 (DGAT1, 71% and 65%), while only PJ decreased aortic lipid peroxides (47%). Substantial TAG‐lowering effects of both PJ and rePON1 were observed also in the heart (31% and 42%), liver (34% and 42%), and kidney (42% and 57%). In both VAT and SAT, rePON1 decreased the levels of lipid peroxides (28% and 25%), while PJ decreased the TAG content (22% and 18%). Ex vivo incubation of SAT with serum derived from mice that consumed PJ or injected with rePON1 decreased SAT lipid peroxides (35% or 28%) and TAG mass (12% or 10%). These novel findings highlight potent TAG‐lowering properties of exogenous (PJ) and endogenous (PON1) antioxidants in tissues associated with CVD.

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Pomegranate juice prevents development of non‐alcoholic fatty liver disease in rats by attenuating oxidative stress and inflammation

Abstract: The data obtained in the present study indicate that the regular consumption of PJ can prevent NAFLD even in the presence of the other risk factors such as obesity, hypercholesterolemia, and high energy, fat and sugar intakes. © 2016 Society of Chemical Industry.

Cited by 47 publications

References 25 publications

Beneficial Effects of Pomegranate on Lipid Metabolism in Metabolic Disorders

Beneficial Effects of Pomegranate on Lipid Metabolism in Metabolic Disorders

The effects of black seed supplementation on cardiovascular risk factors in patients with nonalcoholic fatty liver disease: A randomized, double‐blind, placebo‐controlled clinical trial

Exogenous (Pomegranate Juice) or Endogenous (Paraoxonase1) Antioxidants Decrease Triacylglycerol Accumulation in Mouse Cardiovascular Disease‐Related Tissues

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