Pomegranate peel extract polyphenols attenuate the SARS-CoV-2 S-glycoprotein binding ability to ACE2 Receptor: In silico and in vitro studies

Suručić, Relja; Travar, Maja; Petković, Miroslav; Tubić, Biljana; Stojiljković, Miloš P.; Grabež, Milkica; Šavikin, Katarina; Zdunić, Gordana; Škrbić, Ranko

doi:10.1016/j.bioorg.2021.105145

Cited by 43 publications

(40 citation statements)

References 39 publications

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“…A more precise suggestion was made by Prussin II [21], who clearly indicated that the phi6 phage particles may be selected as a surrogate for coronaviruses. These assumptions were confirmed by Surucic et al [34] who indicated that pomegranate polyphenolic compounds have the potential to attenuate the ability of SARS-CoV-2 S-glycoprotein to bind to the ACE2 receptor and therefore to be excellent candidates for possible therapeutic application. It should be also mentioned that the authors suggest the possible synergistic effect of pomegranate polyphenols.…”

Section: Discussionmentioning

confidence: 72%

Polyethylene Films Coated with Antibacterial and Antiviral Layers Based on CO2 Extracts of Raspberry Seeds, of Pomegranate Seeds and of Rosemary

et al. 2021

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The main goal of the work was to create an internal coating based on super critical CO2 extracts of raspberry seeds, pomegranate seeds and rosemary that could be active against chosen bacterial strains. Additionally, the synergistic effect of these substances in the coating were then analysed. The next goal of the work was to demonstrate the antiviral activity of the coatings against phi6 bacteriophage particles (airborne viruses surrogate). The results of the study indicated that three coatings containing a mixture of extracts showed bacteriolytic activity against S. aureus cells and bacteriostatic activity against E. coli and B. subtilis strains. Two coatings showed bacteriolytic activity against a P. syringae strain. As a result of the experiments, a synergistic effect was noted in the active additives/compounds in the coatings. These coatings may be used as internal coatings for packaging films to extend the shelf life of selected food products. All seven coatings may also be used as external coatings with antiviral activity, as these coatings demonstrated significant effects on the phi6 phage, selected as a surrogate for airborne viruses, e.g., coronaviruses. It could be concluded that coatings I–VII will also show antiviral effects on SARS-CoV-2 particles.

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Section: Discussionmentioning

confidence: 72%

Polyethylene Films Coated with Antibacterial and Antiviral Layers Based on CO2 Extracts of Raspberry Seeds, of Pomegranate Seeds and of Rosemary

et al. 2021

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“…For example, PUG was identified as an allosteric inhibitor of SARS-CoV-2 3CLpro main protease ( Du et al, 2021 ; Khalifa et al, 2020 ; Tito et al, 2021 ), which functions to cleave the polyproteins to generate nonstructural proteins. Moreover, PUG was also shown to interfere with the interaction between the virus spike glycoprotein and the cellular receptor ACE2 ( Surucic et al, 2021 ; Tito et al, 2021 ), and thereby might have potential inhibitory effects on the virus entry into the host cells. Our results showed that PUG directly binds NSP13 with a KD value of 21.6 nM, inhibits the helicase activity of NSP13 (IC 50 ∼ 430 nM).…”

Section: Discussionmentioning

confidence: 99%

Punicalagin as an allosteric NSP13 helicase inhibitor potently suppresses SARS-CoV-2 replication in vitro

Peng

Yao

et al. 2022

Antiviral Research

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“…Given this, it is interesting to note that urolithin metabolites can exert a mild anti-SARS-CoV-2 Mpro inhibition ( 113 ) at physiological relevant concentrations (2–50 μM), detectable in human colon tissues after consumption of hydrolyzable tannin-rich foods, as per clinical studies ( 114 ). Also, the pomegranate peel extract, punicalin, punicalagin, and UA have the potential to block the SARS-CoV-2 spike (S) glycoprotein receptor-binding domain (RBD)-ACE2 receptor on host cells contact, which is one of the first steps of virus infection ( 115 ). Additionally, it has been understood that SARS-Cov-2 can activate pro-inflammatory chemokines in the early stage, and this can lead to the development of either a protective immune response or an exacerbated inflammatory response ( 116 ).…”

Section: Coronavirus Disease (Covid-19)mentioning

confidence: 99%

Urolithins: The Colon Microbiota Metabolites as Endocrine Modulators: Prospects and Perspectives

et al. 2022

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Selective estrogen receptor modulators (SERMs) have been used in hormone related disorders, and their role in clinical medicine is evolving. Tamoxifen and raloxifen are the most commonly used synthetic SERMs, and their long-term use are known to create side effects. Hence, efforts have been directed to identify molecules which could retain the beneficial effects of estrogen, at the same time produce minimal side effects. Urolithins, the products of colon microbiota from ellagitannin rich foodstuff, have immense health benefits and have been demonstrated to bind to estrogen receptors. This class of compounds holds promise as therapeutic and nutritional supplement in cardiovascular disorders, osteoporosis, muscle health, neurological disorders, and cancers of breast, endometrium, and prostate, or, in essence, most of the hormone/endocrine-dependent diseases. One of our findings from the past decade of research on SERMs and estrogen modulators, showed that pomegranate, one of the indirect but major sources of urolithins, can act as SERM. The prospect of urolithins to act as agonist, antagonist, or SERM will depend on its structure; the estrogen receptor conformational change, availability and abundance of co-activators/co-repressors in the target tissues, and also the presence of other estrogen receptor ligands. Given that, urolithins need to be carefully studied for its SERM activity considering the pleotropic action of estrogen receptors and its numerous roles in physiological systems. In this review, we unveil the possibility of urolithins as a potent SERM, which we are currently investigating, in the hormone dependent tissues.

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Pomegranate peel extract polyphenols attenuate the SARS-CoV-2 S-glycoprotein binding ability to ACE2 Receptor: In silico and in vitro studies

Abstract: Graphical abstract

Cited by 43 publications

References 39 publications

Polyethylene Films Coated with Antibacterial and Antiviral Layers Based on CO2 Extracts of Raspberry Seeds, of Pomegranate Seeds and of Rosemary

Polyethylene Films Coated with Antibacterial and Antiviral Layers Based on CO2 Extracts of Raspberry Seeds, of Pomegranate Seeds and of Rosemary

Punicalagin as an allosteric NSP13 helicase inhibitor potently suppresses SARS-CoV-2 replication in vitro

Urolithins: The Colon Microbiota Metabolites as Endocrine Modulators: Prospects and Perspectives

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