Nowadays, in addition to the thermodynamic properties of refrigerants, their impact on the environment is of high significance. Hence, it is important to use refrigerants with the lowest possible values of ozone depletion potential and global warming potential indices in refrigeration, organic Rankine cycle (ORC), air conditioning, and heat pump systems. Natural refrigerants are the most environmentally friendly; unfortunately, they have less favourable thermodynamic properties. Currently, low-pressure refrigerants from the FC (fluorocarbons, fluorine liquids) and HFE (hydrofluoroether) groups are increasingly used. This paper presents the most important properties and applications of selected refrigerants from these groups and also reviews the literature on their use.