Pooled analysis of recent studies on magnetic fields and childhood leukaemia

Kheifets, Leeka; Ahlbom, Anders; Crespi, Catherine M.; Draper, G J; Hagihara, Jun; Lowenthal, Ray M.; Mezei, Gábor; Oksuzyan, Sona; Schüz, Joachim; Swanson, John; Tittarelli, Andrea; Vinceti, Marco; Filho, Victor Wünsch

doi:10.1038/sj.bjc.6605838

Cited by 207 publications

(170 citation statements)

References 19 publications

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“…The obtained results deny the hypotheses that nighttime measures are more suitable. [22], presented a pooled analysis on primary data from studies on residential magnetic fields and childhood leukemia published after 2000. The main analysis focused on 24-hrs magnetic field measurements, and the results were presenting relation between magnetic fields and childhood leukemia.…”

Section: Relation Between Elf-emf and Childhood Leukemiamentioning

confidence: 99%

Extremely Low Frequency Electromagnetic Field (ELF-EMF) and childhood leukemia near transmission lines: a review

Kokate

Mishra

Lokhande³

et al. 2016

AEM

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Children of the 21st century are continually exposing to multiple sources of electromagnetic field (EMF). By past few years, low frequency between 50 to 60 Hz shows consistent evidences of childhood leukemia(CL) and other epidemiological disorders in European and other developed countries .This article presents a systematic review of most cited studies from developed countries those shed light on the potential relation between childhood leukemia and extremely low frequency electromagnetic field (ELF-EMF). All the findings of articles critically segregated as per human science scale like number of samples, exposure duration, frequency range, distance from the radiation sources, and location during measurement of magnetic field density near power lines. Some other significant effects of change in protein expression, neurological studies are also discussed in this work. The literatures of major studies since last two decade is divided according to pooled analysis /meta-analysis, residential zone assessment and case-control studies.It is very difficult to conclude common conclusion from all the results due non-homogeneous case control studies and complex exposure statistics; however is an attempt to fill the gap between electromagnetic field assessment and medical exposure analysis. The majority of findings were weakly associated with ELF-EMF and childhood leukemia if magnetic field exposure level ≥0.3/0.4 µT. Most of the scientific outcomes show ambiguous support for association with children's health residing near power transmission line. Wide discrepancy between short-term exposure and long-term exposure was observed during statistical analysis. However, the long-term exposure effects may be repeated in the highly populated and developing countries like India. Hence, assessment, review and analysis of ELF-EMF and its co relation with carcinogenic diseases is highly essential to protect young generation from this unknown future threat.

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Section: Relation Between Elf-emf and Childhood Leukemiamentioning

confidence: 99%

Extremely Low Frequency Electromagnetic Field (ELF-EMF) and childhood leukemia near transmission lines: a review

Kokate

Mishra

Lokhande³

et al. 2016

AEM

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“…Ainsi dans l'analyse « poolée » de Kheifets et al (2010), les expositions des études prises en compte étaient différentes sans critère logique les reliant entre elles. Certes elles concernaient l'exposition dans la résidence de l'enfant, mais trois appréciaient le CM mesuré dans la chambre de l'enfant pendant 24 h (Schüz et al, 2001 ;Wünsch-Filho et al, 2011) ou une semaine (Kabuto et al, 2006), trois le CM calculé, en tenant compte de l'historique de charge de la ligne et d'autres caractéristiques de la ligne (Bianchi et al, 2000 ;Kroll et al, 2010 ;Malagoli et al, 2010) tandis que la dernière se basait sur la distance entre la résidence et la ligne la plus proche (Lowenthal et al, 2007).…”

Section: La Question Des Leucémies De L'enfantunclassified

“…Ahlbom's "pooled" study (Ahlbom et al, 2000) is the one that has been taken into account in the expertise of the International Agency for Research on Cancer. Kheifets's "pooled" study (Kheifets et al, 2010) is the latest : it takes into account epidemiological studies published between 2000 and 2010.…”

Section: La Question Des Leucémies De L'enfantmentioning

confidence: 99%

Champs magnétiques 50–60 Hz et santé : quoi de neuf ?

Souques¹,

Lambrozo²

2015

Radioprotection

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“…Since then, a large number of epidemiological studies have been published, investigating the suggested association between extremely low frequency (ELF) EMF and childhood leukaemia (see Kheifets & Shimkhada (2005) for an extensive review). In three pooled analyses (Ahlbom et al 2000, Greenland et al 2000, Kheifets et al, 2010) on previously published case-control studies, an increased relative risk at higher magnetic field strength was found. A biophysical mechanism that could support and verify this suggested association has not been found in ongoing scientific research, although several mechanisms have been hypothesised (see Gee, 2009).…”

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confidence: 99%

Assumptions in quantitative analyses of health risks of overhead power lines

Jong

Wardekker

Sluijs

2012

Environmental Science & Policy

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One of the major issues hampering the formulation of uncontested policy decisions on contemporary risks is the presence of uncertainties in various stages of the policy cycle. In literature, different lines are suggested to address the problem of provisional and uncertain evidence. Reflective approaches such as pedigree analysis can be used to explore the quality of evidence when quantification of uncertainties is at stake. One of the issues where the quality of evidence impedes policy making, is the case of electromagnetic fields. In this case, a (statistical) association was suggested with an increased risk on childhood leukaemia in the vicinity of overhead power lines. A biophysical mechanism that could support this association was not found till date however. The Dutch government bases its policy concerning overhead power lines on the precautionary principle. For the Netherlands, previous studies have assessed the potential number of extra cases of childhood leukaemia due to the presence over overhead power lines. However, such a quantification of the health risk of EMF entails a (large) number of assumptions, both prior to and in the calculation chain. In this study, these assumptions were prioritized and critically appraised in an expert elicitation workshop, using a pedigree matrix for characterization of assumptions in assessments. It appeared that assumptions that were regarded to be important in quantifying the health risks show a high value-ladenness. The results show that, given the present state of knowledge, quantification of the health risks of EMF is premature. We consider the current implementation of the precautionary principle by the Dutch government to be adequate.

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Pooled analysis of recent studies on magnetic fields and childhood leukaemia

Cited by 207 publications

References 19 publications

Extremely Low Frequency Electromagnetic Field (ELF-EMF) and childhood leukemia near transmission lines: a review

Extremely Low Frequency Electromagnetic Field (ELF-EMF) and childhood leukemia near transmission lines: a review

Champs magnétiques 50–60 Hz et santé : quoi de neuf ?

Assumptions in quantitative analyses of health risks of overhead power lines

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