Pooled estimate of world leukoplakia prevalence: a systematic review

Petti, Stefano

doi:10.1016/s1368-8375(03)00102-7

Cited by 327 publications

(230 citation statements)

References 33 publications

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“…In a published systematic review [8], the author estimated a global prevalence of OL of 2.6%, which is in accordance with the consensus that OL prevalence is between 1% and 5% [9,10]. However, isolated reports show variable rates from 0.5% to 26.92% [8].…”

Section: Definition Epidemiology and Etiology Of Oral Leukoplakiassupporting

confidence: 67%

Binary System of Grading Epithelial Dysplasia in Oral Leukoplakias

Carmo¹,

Caldeira²

2013

Carcinogenesis

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Section: Definition Epidemiology and Etiology Of Oral Leukoplakiassupporting

confidence: 67%

Binary System of Grading Epithelial Dysplasia in Oral Leukoplakias

Carmo¹,

Caldeira²

2013

Carcinogenesis

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“…At a workshop coordinated by the WHO in 2005, "potentially malignant disorder" was the preferred terms, with the working group agreeing that the term leukoplakia should be used to recognize "white plaques of questionable risk having excluded (other) known diseases or disorders that carry no increased risk for cancer" (Warnakulasuriya et al, 2007). Prevalence of oral leukoplakia is reported to be approximately 2% (Petti, 2003;Brouns et al, 2013aBrouns et al, , 2013b and the annual malignant transformation rate is estimated to be between 0.13% and 17.5% (Deppe et al, 2012;Kumar et al, 2013;Brouns et al, 2014). Leukoplakia is considered to be the most common premalignant lesion of the oral cavity; its occurrence is related to smoking, with alcohol as an independent factor.…”

Section: Introductionmentioning

confidence: 99%

The treatment of oral leukoplakia with the CO2 laser: A retrospective study of 65 patients

Mogedas-Vegara

Hueto-Madrid

Küstner³

et al. 2015

Journal of Cranio-Maxillofacial Surgery

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a b s t r a c tThe use of CO 2 laser has become a routine procedure for the treatment of oral leukoplakia. In this retrospective study, we evaluated 65 patients with oral leukoplakia treated with CO 2 laser vaporization. The main location was the tongue (n ¼ 21/65, 32.3%). The initial biopsy showed mild/moderate dysplasia in almost half the patients (n ¼ 29, 44.6%) and hyperplasia without dysplasia in around a third of the patients (n ¼ 21, 32.3%). The recurrence and malignant transformation rates were 33.8% (n ¼ 22) and 15.4% (n ¼ 10), respectively. The follow-up mean (standard deviation) was 15.0 (10.6) months. The procedure-related complications rate was 7.7% (n ¼ 5). The KaplaneMeier curves for time to recurrence showed differences only for gingiva lesions compared to tongue lesions (log rank, p ¼ 0.032). Malignant leukoplakia transformation is independent of treatment, although it seems advisable to treat leukoplakia with or without dysplasia.

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“…Among them is oral leukoplakia with a prevalence rate of 0.2 to 3.6% (1)(2)(3)(4)(5). Petti reported an estimated world leukoplakia prevalence of 2% (6), while for van der Waal a rate of 0.5% or lower is more realistic given geographical variations (7). Leukoplakia was described by the World Health Organization as a "Precancerous Lesion" (8).…”

Section: Introductionmentioning

confidence: 99%

Proliferative verrucous leukoplakia: A proposal for diagnostic criteria

Cerero-Lapiedra¹,

et al. 2010

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Proliferative verrucous leukoplakia (PVL) is a rare form of oral leukoplakia, which was first described in 1985 by Hansen et al. Since then, various published case series have presented PVL as a disease with aggressive biological behaviour due to its high probability of recurrence and a high rate of malignant transformation, usually higher than 70%. PVL is a long-term progressive condition, which is observed more frequently in women and elderly patients over 60 years at the time of diagnosis. Eventually, PVL tends to become multifocal with a progressive deterioration of the lesions, making it more and more difficult to control. Tobacco use does not seem to have a significant influence on the appearance or progression of PVL. These lesions may occur both in smokers and nonsmokers. Nevertheless, at present, the aetiology of PVL remains unclear as well as its management and diagnosis, which is still retrospective, late and poorly defined, lacking consensus criteria. Therefore, the aim of this study is to propose a set of diagnostic criteria to allow for the early and objective identification of PVL cases, and thereby conduct an adequate management. The proposal includes five major criteria and four minor criteria, as well as specific combinations among them in order to establish a correct and objective diagnosis of proliferative verrucous leukoplakia.

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Pooled estimate of world leukoplakia prevalence: a systematic review

Cited by 327 publications

References 33 publications

Binary System of Grading Epithelial Dysplasia in Oral Leukoplakias

Binary System of Grading Epithelial Dysplasia in Oral Leukoplakias

The treatment of oral leukoplakia with the CO2 laser: A retrospective study of 65 patients

Proliferative verrucous leukoplakia: A proposal for diagnostic criteria

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