Pooled genetic analysis reveals an association of snps of only a few genes with risk predisposition to ischemic stroke in a <scp>C</scp>hinese population

Zhang, Zhenchang; Su, Gang; Guo, Jia; Li, Jiong; Wu, Hua; Wang, Manxia; Xie, Xiaodong

doi:10.1002/iub.1359

Cited by 3 publications

(2 citation statements)

References 45 publications

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“…Контрольная группа представлена 96 здоровыми военнослужащими по призыву (47,8%). Группы исследуемых сопоставимы по возрасту: для контроля возраст составлял 20,0 [20,5] года, в основной группе -20,0 [19,[9][10][11][12][13][14][15][16][17][18][19][20]2] года (U = 4546,5, p = 0,22).…”

Section: материалы и методыunclassified

“…Полногеномные исследования позволяют определить генетические варианты, способствующие развитию заболевания [10,11]. В настоящее время активно развиваются генетические исследования в направлении прогнозирования соматических и инфекционных заболеваний, а также влияния на макроорганизм генетически модифицированной терапии [12,13].…”

Section: результаты исследованияunclassified

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Prediction of chickenpox in adults

Krivolutskaya¹,

Макаров

2023

Tihookeanskij medicinskij žurnal

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Aim. To evaluate the potential for detecting of gene allelic polymorphism for chickenpox in adults.Materials and methods. The examination involved 201 conscripted soldiers of Caucasian race, aged between 18 and 24, who were born in and served in Zabaykalsky Krai. Determination of gene polymorphism was carried out via polymerase chain reaction. Genomic DNA was extracted from whole blood leukocytes using DNA-Express reagent. IBM SPSS Statistics 25.0 (International Business Machines Corporation, License No. Z125-3301-14, USA) was used for statistical processing of the results.Results. IL-10(G1082A) obtains the highest predictive value for chickenpox, while TLR9(T1237C) – the lowest. More commonly, chickenpox affects adults with IL-10(C819T), IL-10(G1082A) and TLR9(A2848G). TLR9(T1237C) is insignificant for chickenpox. TT and TC IL-10(G1082A), GA and AA TLR9(A2848G), AG and GG IL-10(C819T) are activators of chickenpox. AA IL-10(G1082A), CC IL-10(C819T), AA TLR9(A2848G) are chickenpox protectors. Android app was created for prognosis and early diagnosis of chickenpox in adults.Conclusion. Genes GA, AA IL-10(G1082A, and TT, CT IL-10(C819T), as well as AG, GG TLR9(A2848G) predispose to chickenpox, and gene AA TLR9(A2848G) reduces the probability of developing the disease. Considering that, the main prognostic markers for chickenpox in adults are polymorphisms of genes IL-10(G1082A), TLR9(A2848G), IL-10(C819T), the developed diagnostic model allows for the prediction and early diagnosis of the disease.

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Section: материалы и методыunclassified

Section: результаты исследованияunclassified

Prediction of chickenpox in adults

Krivolutskaya¹,

Макаров

2023

Tihookeanskij medicinskij žurnal

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Gene polymorphisms in calcium-calmodulin pathway: Focus on cardiovascular disease

Beghi

Cavaliere

Buschini

2020

Mutation Research - Reviews in Mutation Research

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Identification of candidate biomarkers and signaling pathways associated with Alzheimer’s disease using bioinformatics analysis of next generation sequencing data

Vastrad,

Vastrad

2024

Preprint

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Alzheimer's disease (AD) is the most common cause of dementia, and one of the most common health problems all over the world. However, the specific molecular mechanisms of AD have not been fully investigated. The current investigation aimed to elucidate potential key candidate genes and signaling pathways in AD. Next generation sequencing (NGS) dataset GSE203206 was downloaded from the Gene Expression Omnibus (GEO) database, which included data from 39 AD samples and 8 normal control samples. Differentially expressed genes (DEGs) were identified using t-tests in the limma R bioconductor package. These DEGs were subsequently investigated by Gene ontology (GO) and pathway enrichment analysis, and a protein-protein interaction (PPI) network and modules were constructed and analyzed. The miRNA-hub gene regulatory network and TF-hub gene regulatory network analysis were performed to identify key miRNAs and TFs. The receiver operating characteristic (ROC) curve analysis was performed to estimate the clinical diagnostic value of the hub genes. A total of 958 DEGs, including 479 up regulated genes and 479 down regulated genes, were screened between AD and normal control samples. GO and pathway enrichment analysis results revealed that the up regulated genes were mainly enriched in response to stimulus, cytoplasm, small molecule binding and signal transduction, whereas down regulated genes were mainly enriched in multicellular organism development, cell junction, ion binding and cardiac conduction. The PPI network contained 4886 nodes and 10342 edges. HSP90AA1, FN1, KIT, YAP1, LSM2, SKP1, EIF5A2, TAF9, DDX39B and CDK7 were identified as the top hub genes. The regulatory network analysis revealed that microRNA (miRNA) hsa-mir-545-3p and hsa-miR-548f-5p, and transcription factor (TF) PLAG1 and MEF2A might be involved in the development of AD. These findings provide new insights into the pathogenesis of AD. The hub genes, miRNAs and TFs have the potential to be used as diagnostic and therapeutic markers.

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Pooled genetic analysis reveals an association of snps of only a few genes with risk predisposition to ischemic stroke in a Chinese population

Cited by 3 publications

References 45 publications

Prediction of chickenpox in adults

Prediction of chickenpox in adults

Gene polymorphisms in calcium-calmodulin pathway: Focus on cardiovascular disease

Identification of candidate biomarkers and signaling pathways associated with Alzheimer’s disease using bioinformatics analysis of next generation sequencing data

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