Poor bladder compliance due to malacoplakia with xanthogranulomatous cystitis

Abstract

Rationale: Either malacoplakia or xanthogranulomatous cystitis (XC) is a rare chronic infection disease of urinary bladder, which often mimics bladder masses undifferentiated from malignance and results in severe lower urinary tract symptoms. The malacoplakia combined with XC is even rarer in the literature. Patient concerns: A 64-year-old female, who presented with nocturia, frequency of micturition, severe urgency with occasional urinary incontinence, and recurrent hematuria for >2 years, was diagnosed with azotemia and anemia. In addition, two 1.0 × 1.0 cm masses of bladder were detected by computer tomography. Diagnoses: Malacoplakia combined with xanthogranulomas cystitis was diagnosed histologically. Video urodynamic test showed poor bladder compliance (9 mL/comH2O), markedly decreased maximum bladder capacity (120 mL), and right vesicoureteral reflux at a low intravesical pressure level (25 cmH2O). Interventions: Transurethral resection of bladder masses was carried out after treatment of urinary infection by intravenous piperacillin-tazobactam. Oral Ciprofloxacin and Tolterodine were postoperatively used to prevent recurrent lower urinary tract infections and alleviate detrusor overactivity. Outcomes: The treatment did not alleviate azotemia, frequency, urgency with incontinence, and bilateral hydroureteronephrosis, but the patient refused to undergo bladder augmentation on account of her poor economic status. Lessons: Malacoplakia or/and xanthogranulomas cystitis may lead to poor bladder compliance and video urodynamic study should be considered in patients with refractory chronic lower urinary tract symptoms.

Malacoplakia of the bladder combined with infected renal calculi: A case report

“…This disease usually occurs in immunocompromised individuals, with E. coli being the most common pathogen. The malacoplakia of the bladder combined with yellow granulomatous cystitis has been reported previously ( 7 ). Cases of bladder stones in combination with malacoplakia of the bladder have been reported earlier ( 8 ), and in this case, the patient had diabetes mellitus and renal stones with recurrent urinary tract infections.…”

“…This disease usually occurs in immunocompromised individuals, with E. coli being the most common pathogen. The malacoplakia of the bladder combined with yellow granulomatous cystitis has been reported previously (7). Cases of bladder stones in combination with malacoplakia of…”