Poor Correlation of Histologic Parameters Between Biopsy and Resection Specimen in Early Stage Oral Squamous Cell Carcinoma

Abstract

Histologic parameters in biopsy specimens do not represent the resection specimen. Determination of histologic parameters in routinely taken biopsy specimens of OSCC is not helpful in deciding whether to treat the neck.

Poor prognosis in human papillomavirus–positive oropharyngeal squamous cell carcinomas that overexpress hypoxia inducible factor‐1α

“…The treatment strategy may also play a role in this, because in patients treated with RT only, tissue from incisional biopsies is available. It was recently described that histological features of incisional biopsies correspond poorly to the resected whole tumor . This may have also played a role in not finding a significant correlation between HIF‐1α overexpression and differentiation grade.…”

Prognostic and predictive markers for perineural and bone invasion of oral squamous cell carcinoma

“…Mortality rates and treatment -related morbidity of patients with OSCC are still exceedingly high, challenging the available methods of diagnostic and prognostic assessment, and encouraging the search for new and better tools, namely molecular markers that relate comprehensively to known characteristics of tumor progression and invasiveness [57][58][59] . The standard approach to the prognosis still relies on classical TNM staging, with metric factors such as tumor size and thickness, and number and size of possible lymphnode or distant metastases 31,60 . Bobdey et al developed accurate and efficient nomogram to predict the probability of 3-year survival in T4 buccal mucosa cancer patients.…”

Amplification and protein overexpression of cyclin D1: Predictor of occult nodal metastasis in early oral cancer

“…However, it must be realized, that the benefit of the biomarker lies in its preoperative application on the incisional biopsy: to decide whether or not to perform a neck dissection at the same time when resecting the primary tumor. Reliable acquisition of the histological tumor characteristics can only take place after the ablative surgery …”