Poor glycemic control impacts heart rate variability in patients with type 2 diabetes mellitus: a cross sectional study

Nganou–Gnindjio, Chris Nadège; Camille, Michael; Azabji-Kenfack, Marcel; Dehayem, Mesmin; Mfeukeu-Kuaté, Liliane; Mbanya, Jean Claude; Sobngwi, Eugène

doi:10.1186/s13104-018-3692-z

Cited by 13 publications

(11 citation statements)

References 9 publications

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“…ere are also 40 subjects (91%) who had hypertension. Since high blood pressure and poor glycemic control is associated with reduced HRV, all hypertensive and diabetic subjects included in our study must be in optimal blood pressure and glycemic control (blood pressure <140/90 mmHg, fasting plasma glucose <130 mg/dL, and post prandial plasma glucose <180 mg/dL, or HbA1C <7.5%) [14,15]. erefore, coronary revascularization may restore autonomic balance, which is characterized by increased heart rate variability towards an optimal level.…”

Section: Discussionmentioning

confidence: 99%

Increased Heart Rate Variability following Elective Percutaneous Coronary Intervention in Patients with Stable Coronary Artery Disease and Preprocedural Anxiety

Oktaramdani

Mudjaddid

Muhadi

et al. 2019

Cardiology Research and Practice

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Background. There is a strong association between chronic ischemia and autonomic imbalance. Percutaneous coronary intervention (PCI) may restore autonomic balance in patients with stable coronary artery disease (SCAD), which is characterized by increased heart rate variability (HRV). Anxiety is often found in patients who are going to undergo invasive procedures and has been identified to induce autonomic imbalance. The aim of our study is to identify the impact of preprocedural anxiety on increased HRV following an elective PCI. Methods. Our study was a pretest and post-test correlation study involving 44 SCAD patients who underwent elective PCI at Cipto Mangunkusumo National Hospital. The HRV was measured before and after PCI. Anxiety symptoms were evaluated using Hospital Anxiety Depression Score (HADS) questionnaires. Results. We found a higher increase on HRV parameter following the PCI of subjects in the nonanxiety group compared with the anxiety group (median = 9.11 vs. 2.83; U = 154.00; p=0.043). Conclusions. Preprocedural anxiety may inhibit HRV increase following PCI procedure.

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Section: Discussionmentioning

confidence: 99%

Increased Heart Rate Variability following Elective Percutaneous Coronary Intervention in Patients with Stable Coronary Artery Disease and Preprocedural Anxiety

Oktaramdani

Mudjaddid

Muhadi

et al. 2019

Cardiology Research and Practice

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“…Impairment in glucose homeostasis is associated with lower HRV without diabetes, most prominently in men and individuals with abdominal adiposity 17 . Frequency domain analysis has shown trends towards lower values of sympathovagal balance in poorly controlled patients with T2DM 18 . Reduced HRV is associated with an increased risk of cardiovascular disease and mortality.…”

Section: Introductionmentioning

confidence: 99%

Effects of obesity and diabesity on heart rhythm in the Zucker rat

Sultan

Jacobson

Adeghate

et al. 2021

Clin Exp Pharma Physio

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Obesity and type 2 diabetes mellitus are risk factors for hypertension, coronary heart disease, cardiac arrhythmias including atrial fibrillation, heart failure and sudden cardiac death. The effects of obesity and diabesity on heart rhythm were investigated in the Zucker diabetic fatty (ZDF) and Zucker fatty (ZF) compared to the Zucker lean (ZL) control rat. In vivo biotelemetry techniques were used to assess the electrocardiogram and other cardiac and metabolic parameters. ZDF rats were characterized by age‐dependent elevations in fasting and non‐fasting blood glucose, glucose intolerance and weight gain and ZF rats were characterized by smaller elevations in fasting and non‐fasting blood glucose and greater weight gain compared to ZL rats. Heart rate (HR) was progressively reduced in ZDF, ZF and ZL rats. At 195 days (6.5 months) of age there were significant differences in HR between ZDF (265 ± 8 bpm, n = 10), ZF (336 ± 9 bpm, n = 10) and ZL (336 ± 10 bpm, n = 10) rats and significant differences in HRV between ZDF (22 ± 1 bpm, n = 10), ZF (27 ± 1 bpm, n = 10) and ZL (31 ± 1 bpm, n = 10) rats. Power spectral analysis revealed no significant (P > 0.05) differences in HRV at low frequencies, reduced HRV at high frequencies and increased sympathovagal balance in ZDF compared to ZF and ZL rats. HR was reduced by ageing and additionally reduced by diabesity in the absence of changes in physical activity and body temperature. Reductions in HRV associated with altered sympathovagal drive might partly underlie disturbed HR in the ZDF rat. Possible explanations for reduced HR and future mechanistic studies are discussed.

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“…[29] Studies have already demonstrated the reduced HRV could be regarded as early indicators of cardiac autonomic dysfunction. [7,30,31] This study found that vitamin D levels of T2DM patients in the deficiency group were associated with reduced SDNN, ASDNN, pNN50, LF, HF, SDANN, and rMSSD. Meanwhile, the LF/HF in the deficiency group was significantly higher than those in the sufficiency group.…”

Section: Discussionmentioning

confidence: 63%

The association between vitamin D levels and heart rate variability in patients with type 2 diabetes mellitus

Chen

Cheng

et al. 2022

Medicine

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To assess the association between serum vitamin D levels and heart rate variability in patients with type 2 diabetes mellitus (T2DM). This study included 469 patients who were retrospective assessed for eligibility from Changzhou Second People’s Hospital, Affiliated Nanjing Medical University, between March 2013 and June 2020. A total of 191 T2DM patients were recruited and divided into 3 groups. A total of 191 patients were recruited. A significant difference was noted among groups for HbA1c (P < .001), serum uric acid (P = .048), and urea nitrogen (P = .043). The Vitamin D level in deficiency, insufficiency, and sufficient was 23.17, 38.89, and 63.01 nmol/L, respectively. The insufficient group had lower levels of percentage of normal-to-normal intervals differing by more than 50 milliseconds, and the square root of the mean of the squares of the differences between adjacent normal-to-normal R peak-to-R-peak time intervals than the sufficient vitamin D group. Furthermore, patients in deficiency and insufficiency group were associated with high level of low frequency power/high frequency power as compared with sufficient vitamin D group. Finally, serum 25-hydroxyvitamin D (25(OH)D) levels were positively correlated with rMSSD (P = .002). This study found that low serum 25(OH)D levels were associated with reduced heart rate variability parameters in patients with T2DM.

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Poor glycemic control impacts heart rate variability in patients with type 2 diabetes mellitus: a cross sectional study

Cited by 13 publications

References 9 publications

Increased Heart Rate Variability following Elective Percutaneous Coronary Intervention in Patients with Stable Coronary Artery Disease and Preprocedural Anxiety

Increased Heart Rate Variability following Elective Percutaneous Coronary Intervention in Patients with Stable Coronary Artery Disease and Preprocedural Anxiety

Effects of obesity and diabesity on heart rhythm in the Zucker rat

The association between vitamin D levels and heart rate variability in patients with type 2 diabetes mellitus

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