Poor oocyte quality rather than implantation failure as a cause of age-related decline in female fertility

Navot, Daniel; Bergh, R.A.; Williams, M.A.; Garrisi, G. John; Guzman, Ida; Sandler, B.; Grunfeld, L.

doi:10.1016/0140-6736(91)93060-m

Cited by 485 publications

(157 citation statements)

References 14 publications

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“…They recruited women aged over 40 who had failed attempts at conception with their own oocytes and found that they had a significantly increased pregnancy and delivery rate with IVF from donated oocytes from younger women than with their own oocytes. Their data supports the idea that a decline in female fecundity with age is attributable largely to oocyte quality and is correctable by ovum donation [16].…”

Section: Introductionsupporting

confidence: 62%

What is the best treatment option for infertile women aged 40 and over?

Armstrong

Akande

2013

J Assist Reprod Genet

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Purpose To summarise the causes of decreased fecundity with age and review chronological vs biological ovarian ageing. To explore the clinician's means of assessing a woman's ovarian reserve. To review the recent literature on the effectiveness of different assisted reproductive technology (ART) techniques for women aged 40 and over and offer a single best treatment option. Methods Pubmed and google scholar were searched for relevant articles using key words. Data were extracted based on authors, year, aims, sample and results. Results Success rates for women aged 40 or over with clomiphene, IUI, IUI with FSH are all extremely low, at less than 1 % live birth per cycle. However, IVF offers a success rate of around 13.7 % per cycle. Conclusion An exploration of the effectiveness of available treatment options for older infertile women using their own gametes suggests that IVF offers the best prospects of success. Attempting treatments other than IVF will delay conception unnecessarily.

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Section: Introductionsupporting

confidence: 62%

What is the best treatment option for infertile women aged 40 and over?

Armstrong

Akande

2013

J Assist Reprod Genet

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“…Increase in maternal age is known to have a negative impact on fertility secondary to reduced ovarian reserve [1,2]. Numerous studies concluded that obesity, as defined by a BMI>25 kg/m 2 negatively correlates with fertility potential, affecting ovulation, pregnancy rates and outcomes in natural and treated cycles [3,4].…”

Section: Introductionmentioning

confidence: 99%

Low grade inflammation, as evidenced by basal high sensitivity CRP, is not correlated to outcome measures in IVF

Robinson

Pemberton

Laing

et al. 2008

J Assist Reprod Genet

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Purpose To assess the relationship between low-grade inflammation, measured as basal high sensitivity (hs)-CRP, and IVF outcome. Methods We recruited a total of 220 women undergoing infertility work up prior to IVF. Patients were selected for a BMI<30 kg/m 2 with an upper age limit of 40 years. Serum hs-CRP levels were measured on day 3 of a spontaneous menstrual cycle preceding ovarian stimulation. A sensitive two-site ELISA was used for analysis. Dose of gonadotrophins required, follicles days 8 and 10, number of oocytes collected, number of oocytes fertilised and pregnancy outcome were recorded. Results Median hs-CRP was 1.08 mg/L (0.43-3.00 mg/L). The hs-CRP was significantly related to BMI (r=0.386, P<.001) but not to age and smoking habit. There were no significant relationships between basal hs-CRP and any of the measured IVF outcomes. Conclusions These findings demonstrate that serum hs-CRP concentration is not a predictive marker of cycle or pregnancy outcome in women undergoing IVF treatment.

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“…The IVF and donor egg programs has provided a more direct means of investigating the relative contribution of the uterus and oocyte to human reproductive senescence. These researches convinced the importance of uterine factors [38], though the oocyte quality is the primary determinant [39][40][41]. All female mammals are born with a limited follicle pool [42], which will support the reproductive lifespan of the individual.…”

Section: Uterine Aging Contributes To Decreased Reproductive Capacitymentioning

confidence: 99%

Determinants of uterine aging: lessons from rodent models

Kong

Zhang

Chen

et al. 2012

Sci. China Life Sci.

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The uterus is an indispensable organ for the development of a new life in eutherian mammals. The female mammalian reproductive capacity diminishes with age. In this respect, the senescence of uterine endometrium is convinced to contribute to this failure. This review focuses on the physiological function of the uterus and the related influence of aging mainly in rodent models. A better understanding of the underlying mechanisms governing the process of uterine aging is hoped to generate new strategies to prolong the reproductive lifespan in humans. . More importantly, this phenomenon of continuous decline of fecundity with age has also been confirmed in women over 35 years old [10][11][12]. The success of reproduction in eutherian mammals requires the uterus, a unique organ in the viviparity compared to other organisms ensuring full development of the new life in the maternal body [13]. The endometrial environment of uteri is proved to be one of the critical aspects to determine the reproductive capacity [14] and uterine factor has been proved to be critical for the decline of fecundity in both rodents and humans [4,15]. Most of the available information on uterine aging derives from studies on rats and mice [16]. In these species, life span is short and aging animal model can be easily established. This review focuses on the physiological function of the uterus and the related influence of aging mainly in rodent models. determinants, uterine aging, rodent models

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Poor oocyte quality rather than implantation failure as a cause of age-related decline in female fertility

Cited by 485 publications

References 14 publications

What is the best treatment option for infertile women aged 40 and over?

What is the best treatment option for infertile women aged 40 and over?

Low grade inflammation, as evidenced by basal high sensitivity CRP, is not correlated to outcome measures in IVF

Determinants of uterine aging: lessons from rodent models

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