Poor oral health may prolong COVID-19 illness

Gupta, Shipra; Sorsa, Timo; Brandt, Ella; Räisänen, Ismo T.; Mohindra, Ritin; Goyal, Kapil

doi:10.1186/s12967-022-03310-0

Cited by 6 publications

(7 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…COVID‐19‐related adverse outcomes seemed to have an association with the severity of periodontitis, this is in agreement with a few previous studies suggesting a similar relationship (Gupta, Saarikko et al, 2022 ; Gupta, Sorsa et al, 2022 ; Marouf et al, 2021 ). Chest findings on CT scans are fast emerging as a standardized methodology to diagnose COVID‐19 infections in patients who have tested negative on RT‐PCR but otherwise remain symptomatic in favor of COVID‐19 (Pakdemirli et al, 2020 ).…”

Section: Discussionsupporting

confidence: 91%

“…Of late, numerous hypotheses and some studies have suggested the possibility of a link between periodontal disease and COVID‐19 adverse outcomes (Gupta & Sahni 2020 ; Gupta, Saarikko et al, 2022 ; Gupta, Mohindra et al, 2022 ; Gupta, Sorsa et al, 2022 ; Sahni & Gupta, 2020 ). In fact, SARS‐CoV‐2 has also been recovered from GCF, further strengthening its rationale to be utilized as a diagnostic fluid (Gupta, Mohindra et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Validation of a noninvasive aMMP‐8 point‐of‐care diagnostic methodology in COVID‐19 patients with periodontal disease

Gupta

Mohindra

Singla

et al. 2022

Clinical & Exp Dental Res

Self Cite

View full text Add to dashboard Cite

Objectives The aim of this study was to validate an active matrix metalloproteinase (MMP‐8) point‐of‐care diagnostic tool in COVID‐19 patients with periodontal disease. Subjects, Materials, and Methods Seventy‐two COVID‐19‐positive and 30 COVID‐19‐negative subjects were enrolled in the study. Demographic data were recorded, periodontal examination carried out, and chairside tests run for evaluating the expression of active MMP‐8 (aMMP‐8) in the site with maximum periodontal breakdown via gingival crevicular fluid sampling as well as via a mouth rinse‐based kit for general disease activity. In COVID‐19‐positive patients, the kits were run again once the patients turned COVID‐19 negative. Results The overall (n = 102) sensitivity/specificity of the mouthrinse‐based kits to detect periodontal disease was 79.41%/36.76% and that of site‐specific kits was 64.71%/55.88% while adjusting for age, gender, and smoking status increased the sensitivity and specificity (82.35%/76.47% and 73.53%/88.24, respectively). Receiver operating characteristic (ROC) analysis for the adjusted model revealed very good area under the ROC curve 0.746–0.869 (p < .001) and 0.740–0.872 (p < .001) (the aMMP‐8 mouth rinse and site‐specific kits, respectively). No statistically significant difference was observed in the distribution of results of aMMP‐8 mouth rinse test (p = .302) and aMMP‐8 site‐specific test (p = .189) once the subjects recovered from COVID‐19. Conclusions The findings of the present study support the aMMP‐8 point‐of‐care testing (PoCT) kits as screening tools for periodontitis in COVID‐19 patients. The overall screening accuracy can be further increased by utilizing adjunctively risk factors of periodontitis. The reported noninvasive, user‐friendly, and objective PoCT diagnostic methodology may provide a way of stratifying risk groups, deciding upon referrals, and in the institution of diligent oral hygiene regimens.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Validation of a noninvasive aMMP‐8 point‐of‐care diagnostic methodology in COVID‐19 patients with periodontal disease

Gupta

Mohindra

Singla

et al. 2022

Clinical & Exp Dental Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…Not only this but patients suffering from periodontal disease have been observed to demonstrate longer periods of illness when afflicted by COVID-19 as was commensurate with the severity of the periodontal disease. Patients in a state of periodontal health demonstrated an average of 4.15 days of being affected by COVID-19, 5.76 days with gingivitis, and 7.37 days with periodontitis, [112]. This further emphasizes the importance of oral health in COVID-19-related outcomes as periodontal diseases seemingly affect every conceivable pathophysiological manifestation of COVID-19.…”

Section: Ammp-8 As An Integral Part Of Perio-covid-19 Connectionmentioning

confidence: 85%

“…The seemingly inseparable relationship between the oral cavity and COVID-19 becomes further manifested in the light of the proven clinical association between the presence of periodontal disease and the occurrence of adverse COVID-19-related outcomes [109][110][111][112]. It has been observed that increased severity of periodontal disease led to a commensurate increase in the necessitation of ventilation (odds ratio 7.45), an odds ratio of 14.58 of succumbing to the disease, an odds ratio of 36.52 for admission to a hospital, and that of 4.42 of suffering from pneumonia-related to COVID-19 [109].…”

Section: Ammp-8 As An Integral Part Of Perio-covid-19 Connectionmentioning

confidence: 99%

aMMP-8 Oral Fluid PoC Test in Relation to Oral and Systemic Diseases

Sorsa

Nwhator

Sakellari

et al. 2022

Front. Oral. Health

Self Cite

View full text Add to dashboard Cite

The manuscript uses the previously published literature and highlights the benefits of active-matrix metalloproteinase (aMMP)-8 chairside/point-of-care (PoC) diagnostic tools as adjunctive measures in oral and systemic diseases. Previous studies suggest that as a biomarker, aMMP-8 is more precise than total MMP-8, MMP-9, MMP-2, MMP-3, MMP-13, MMP-7, MMP-1, calprotectin, myeloperoxidase (MPO), human neutrophil elastase (HNE), tissue inhibitor of matrix metalloproteinase (TIMP)-1, and bleeding of probing (BOP). Therefore, aMMP-8 could be implemented as the needed key biomarker for the new disease classification for both periodontitis and peri-implantitis. With a sensitivity to the tune of 75–85% and specificity in the range of 80–90%, lateral flow aMMP-8 PoC testing is comparable to catalytic protease activity assays for aMMP-8. The test can be further applied to estimate the glycemic status of an individual, to ascertain whether a person is at risk for COVID-19, in managing the oral side effects of radiotherapy carried in head and neck cancers, and in selected cases pertaining to reproductive health. In the future, aMMP-8 could find application as a potential systemic biomarker in diseases affecting the cardiovascular system, cancers, bacteremia, sepsis, diabetes, obesity, meningitis, as well as pancreatitis. The aMMP-8 PoCT is the first practical test in the emerging new dental clinical field, that is, oral clinical chemistry representing oral medicine, clinical chemistry, peri-implantology, and periodontology.

show abstract

“…In the evolving landscape of research, the link with COVID-19 has become a focal point [64][65][66]. Drawing parallels with the established connection between COPD and periodontal disease, we consider the potential oral-lung pathway through which oral infections from periodontitis might heighten susceptibility to COVID-19 infection and/or symptoms [67][68][69].…”

Section: Discussionmentioning

confidence: 99%

Unmasking the Silent Threat: Periodontal Health’s Impact on COPD Severity and Hospitalization

Subbappa,

Lokesh,

Chaya

et al. 2023

JPM

View full text Add to dashboard Cite

Objective: This study investigated the relationship between chronic obstructive pulmonary disease (COPD) and periodontitis, focusing on how periodontal health impacts COPD airflow limitation, exacerbations, and hospitalization. Background: Periodontitis, a multifactorial inflammatory disease, is characterized by destruction of tooth-supporting structures, while COPD is a global pulmonary disorder with high mortality. Methods: A total of 199 COPD patients aged over 40 years underwent lung function tests (spirometry), 6 min walk test, and St George’s Respiratory Questionnaire-COPD (SGRQ-C) to assess lung health. Periodontal indices such as probing depth (PD), clinical attachment loss (CAL), and plaque index (PI) were assessed. Results: We found a significant negative correlation between periodontal disease severity and lung function (lower FEV1, FVC, and FEV1/FVC ratio) after adjusting for smoking. Likewise, periodontal parameters (PPD, PI, and CAL) exhibited negative correlations with lung function. These periodontal indices were independently associated with airflow limitation severity, exacerbations frequency, and prior-year hospitalization. Linear regression indicated that each unit increase in PPD, PI, and CAL corresponded to estimated increases in GOLD airflow limitation grading (0.288, 0.718, and 0.193, respectively) and number of exacerbations (0.115, 0.041, and 0.109, respectively). In logistic regression, PPD, PI, and CAL adjusted odds ratios (ORs) were estimated to increase by 1.29 (95%CI: 1.03–1.62), 3.04 (95%CI: 1.28–7.2), and 1.26 (95%CI: 1.06–1.49), respectively, for hospitalization in previous year. Conclusion: Periodontitis is associated with COPD airflow limitation, exacerbation, and hospitalization, with PI being the most clinically relevant periodontal factor. Dentists and physicians should monitor and increase awareness among COPD patients to maintain oral hygiene for prevention of periodontal diseases and mitigate its effect on COPD progression.

show abstract

Poor oral health may prolong COVID-19 illness

Cited by 6 publications

References 7 publications

Validation of a noninvasive aMMP‐8 point‐of‐care diagnostic methodology in COVID‐19 patients with periodontal disease

Validation of a noninvasive aMMP‐8 point‐of‐care diagnostic methodology in COVID‐19 patients with periodontal disease

aMMP-8 Oral Fluid PoC Test in Relation to Oral and Systemic Diseases

Unmasking the Silent Threat: Periodontal Health’s Impact on COPD Severity and Hospitalization

Contact Info

Product

Resources

About