Poor postnatal head growth in very preterm infants is associated with impaired neurodevelopment outcome

Neubauer, Vera; Griesmaier, Elke; Pehböck-Walser, Nicola; Pupp‐Peglow, Ulrike; Kiechl‐Kohlendorfer, Ursula

doi:10.1111/apa.12319

Cited by 79 publications

(74 citation statements)

References 22 publications

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“…Previous data support the fact that HC catch-up growth has a significant beneficial effect on neuromotor scores and neurocognitive outcome [9,10]. By contrast, suboptimal HC postnatal growth is associated with impaired cognitive and psychomotor development [11]. …”

Section: Introductionmentioning

confidence: 72%

Fetal and Postnatal Head Circumference Growth: Synergetic Factors for Neurodevelopmental Outcome at 2 Years of Age for Preterm Infants

Sicard¹,

Nusinovici

Hanf

et al. 2017

Neonatology

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Preterm infants present higher risk of non-optimal neurodevelopmental outcome. Fetal and postnatal growth, in particular head circumference (HC), is associated with neurodevelopmental outcome. Objectives: We aimed to calculate the relationship between HC at birth, HC delta Z-score (between birth and hospital discharge), and non-optimal neurodevelopmental outcome at 2 years of corrected age in preterm infants. Methods: Surviving infants born ≤34 weeks of gestation were included in the analysis. The relationship between the risk of being non-optimal at 2 years and both HC at birth and HC growth was assessed. The 2 Z-scores were considered first independently and then simultaneously to investigate their effect on the risk of non-optimality using a generalized additive model. Results: A total of 4,046 infants with both HC measures at birth and hospital discharge were included. Infants with small HC at birth (Z-score <-2 SD), or presenting suboptimal HC growth (dZ-score <-2 SD), are at higher risk of non-optimal neurodevelopmental outcome at 2 years (respectively OR 1.7 [95% CI 1.4-2] and OR 1.4 [95% CI 1.2-1.8]). Interestingly, patients cumulating small HC Z-score at birth (-2 SD) and presenting catch-down growth (HC dZ-score [-2 SD]) have a significantly increased risk for neurocognitive impairment (OR >2) while adjusting for gestational age, twin status, sex, and socioeconomic information. Conclusions: HC at birth and HC dZ-score between birth and hospital discharge are synergistically associated to neurodevelopmental outcome at 2 years of corrected age, in a population-based prospective cohort of preterm infants born ≤34 weeks of gestation.

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Section: Introductionmentioning

confidence: 72%

Fetal and Postnatal Head Circumference Growth: Synergetic Factors for Neurodevelopmental Outcome at 2 Years of Age for Preterm Infants

Sicard¹,

Nusinovici

Hanf

et al. 2017

Neonatology

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“…Maternal and neonatal data as described in our previous paper were collected during hospital stay [5]. Detailed information is given in online supplemental material (for all online suppl.…”

Section: Methodsmentioning

confidence: 99%

Bronchopulmonary Dysplasia Is Associated with Delayed Structural Brain Maturation in Preterm Infants

Neubauer¹,

Junker

Griesmaier³

et al. 2015

Neonatology

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Background: In recent years, cerebral magnetic resonance imaging (MRI) has been increasingly used to depict the wide spectrum of preterm brain injury. Furthermore, it has already been demonstrated by MRI at term-equivalent age (TEA) that preterm infants show delayed brain maturation as compared to term infants, and this delay has been related to neurobehavioral outcome. Objectives: The aim of the current study was to investigate the influence of prevalent neonatal risk factors for adverse outcome on structural brain maturation in very preterm infants at TEA. Methods: One hundred and thirty very preterm infants born at a mean gestational age of 29.7 weeks were included. MRI was performed at TEA and given a validated ‘total maturation score'. Brain maturation scores were compared with neonatal data. Results: In univariate analysis, bronchopulmonary dysplasia (BPD), late-onset sepsis and retinopathy of prematurity were significantly associated with delayed brain maturation. Furthermore, infants with delayed maturation had been ventilated significantly longer and more often suffered from severe arterial hypotension. In multivariate analysis, BPD remained significant as predictor of delayed brain maturation. Conclusions: This study is the first to show that delayed structural brain maturation as evaluated by MRI at TEA is preceded by BPD, which is known to be a predictor of adverse outcome in preterm infants. This finding adds further evidence to show that adverse outcome in preterm infants may have additional neural correlates that exceed common brain injury.

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“…7,8,18,19,[21][22][23]27,33 Neurodevelopmental outcome at $2 years was reported in eleven studies (3,817 subjects). 7,9,10,12,14,18,19,21,27,28,36 Nine studies (2,363 subjects) included neuroimaging data, four of which report magnetic resonance imaging (MRI) data. 7,30,32,35 Infants born at #28 weeks gestation (Table S1) were examined in 12 studies, while 22 studies focused on infants of .28 weeks completed gestation (Table S2).…”

Section: Resultsmentioning

confidence: 99%

Head size and growth in the very preterm infant: a literature review

Lee¹,

Hayes²

2015

RRN

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Poor postnatal head growth in very preterm infants is associated with impaired neurodevelopment outcome

Abstract: Poor postnatal head growth was common in our study cohort. Both microcephaly and suboptimal head size were associated with impaired neurodevelopmental outcome. Suboptimal head size at 3 months was found to be particularly associated with adverse neurodevelopmental outcome.

Cited by 79 publications

References 22 publications

Fetal and Postnatal Head Circumference Growth: Synergetic Factors for Neurodevelopmental Outcome at 2 Years of Age for Preterm Infants

Fetal and Postnatal Head Circumference Growth: Synergetic Factors for Neurodevelopmental Outcome at 2 Years of Age for Preterm Infants

Bronchopulmonary Dysplasia Is Associated with Delayed Structural Brain Maturation in Preterm Infants

Head size and growth in the very preterm infant: a literature review

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