Poor quality diet is associated with overweight status and obesity in patients with polycystic ovary syndrome

Rodrigues, Ana Maria dos Santos; Martins, Laís Bhering; Franklin, A; Cândido, Alexandre Luna; Santos, Luana Caroline dos; Ferreira, Adaliene Versiani Matos

doi:10.1111/jhn.12205

Cited by 18 publications

(14 citation statements)

References 46 publications

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“…Homocysteine concentrations were higher as well, although this did not reach statistical significance. The study of Rodrigues et al supports this finding showing a poor diet quality in PCOS patients (56% inadequacy according to the Brazilian healthy eating index) [ 36 ]. Studies comparing diet quality in PCOS to controls are contradictory.…”

Section: Discussionmentioning

confidence: 73%

Are Dieting and Dietary Inadequacy a Second Hit in the Association with Polycystic Ovary Syndrome Severity?

et al. 2015

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BackgroundThe composition of the diet is of increasing importance for the development and maturation of the ovarian follicles. In Polycystic Ovary Syndrome (PCOS) healthy dietary interventions improve the clinical spectrum. We hypothesized that dieting and diet inadequacy in the reproductive life course is associated with impaired programming of ovarian follicles and contributes to the severity of the PCOS phenotype.Methods and FindingsTo determine associations between the use of a self-initiated diet and diet inadequacy and the severity of the PCOS phenotype, we performed an explorative nested case control study embedded in a periconception cohort of 1,251 patients visiting the preconception outpatient clinic. 218 patients with PCOS and 799 subfertile controls were selected from the cohort and self-administered questionnaires, anthropometric measurements and blood samples were obtained. The Preconception Dietary Risk Score (PDR score), based on the Dutch dietary guidelines, was used to determine diet inadequacy in all women. The PDR score was negatively associated to cobalamin, serum and red blood cell folate and positively to tHcy. PCOS patients (19.9%), in particular the hyperandrogenic (HA) phenotype (22.5%) reported more often the use of a self-initiated diet than controls (13.1%; p = 0.023). The use of an inadequate diet was also significantly higher in PCOS than in controls (PDR score 3.7 vs 3.5; p = 0.017) and every point increase was associated with a more than 1.3 fold higher risk of the HA phenotype (adjusted OR 1.351, 95% CI 1.09–1.68). Diet inadequacy was independently associated with the anti-Müllerian Hormone (AMH) concentration (β 0.084; p = 0.044; 95% CI 0.002 to 0.165) and free androgen index (β 0.128; p = 0.013; 95% CI 0.028 to 0.229) in PCOS patients.ConclusionsThe use of a self-initiated diet and diet inadequacy is associated with PCOS, in particular with the severe HA phenotype. This novel finding substantiated by the association between diet inadequacy and AMH needs further investigation.

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Section: Discussionmentioning

confidence: 73%

Are Dieting and Dietary Inadequacy a Second Hit in the Association with Polycystic Ovary Syndrome Severity?

et al. 2015

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“…Cross-sectional studies have associated low diet quality with obesity 30 , cardiovascular risk factors 31 and systemic inflammation 32 . A meta-analysis of cohort studies concluded that diets with high quality scores were associated with a significant reduction in the risk of all-cause mortality, cardiovascular disease, cancer and type 2 diabetes mellitus 28 .…”

Section: Discussionmentioning

confidence: 99%

Nutritional intervention may improve migraine severity: a pilot study

Costa

Rodrigues

Martins

et al. 2019

Arq. Neuro-Psiquiatr.

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Although some studies have investigated the role of nutritional intervention on migraine, they had focused on triggers or on weight change and, to the best of our knowledge, none studied diet quality. Objective To investigate whether nutritional intervention focused on improving diet quality and healthy weight can promote improvement in clinical parameters of women with migraine. Methods Non-controlled and non-randomized intervention study conducted for 90 days. Women received an individualized diet meal plan and nutritional orientation according to their nutritional diagnosis. Anthropometric, clinical and nutritional data were measured once a month. Diet energy content and macronutrients were evaluated using 24-hour dietary recall. Diet quality was assessed through the Brazilian Healthy Eating Index–Revised (BHEI-R). The Migraine Disability Assessment and Headache Impact Test version 6 were used to assess the severity of migraine, and the Beck Depression Inventory evaluated depressive symptoms. Results Fifty-two women aged 44.0 ± 13.0 years were enrolled. Anthropometric characteristics, energy, macronutrients and fiber intake did not change after intervention. However, the BHEI-R scores improved after 60 and 90 days of intervention. Concurrent to this, the Beck Depression Inventory scores and Headache Impact Test scores decreased after 60 and 90 days, respectively. The change in the BHEI-R score was negatively correlated with the migraine severity as assessed by the Headache Impact Test at the end of the intervention. Conclusions We concluded that the management of diet quality may be a good strategy for improving migraine severity, regardless of the nutritional status and weight change.

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“…Multiple environmental and/or genetic factors contribute to the pathogenesis of PCOS (5,7,8) . Lifestyle modifications are considered as the first-line treatment for women with PCOS (9)(10)(11) .…”

Section: Introductionmentioning

confidence: 99%

Dietary carbohydrate composition is associated with polycystic ovary syndrome: a case–control study

Eslamian

Baghestani

Eghtesad

et al. 2016

J Human Nutrition Diet

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Poor quality diet is associated with overweight status and obesity in patients with polycystic ovary syndrome

Abstract: Dietary interventions focused on improvement of diet quality should be targeted to treat patients with PCOS because obesity in these women is associated with worsening endocrine, metabolic and reproductive functions.

Cited by 18 publications

References 46 publications

Are Dieting and Dietary Inadequacy a Second Hit in the Association with Polycystic Ovary Syndrome Severity?

Are Dieting and Dietary Inadequacy a Second Hit in the Association with Polycystic Ovary Syndrome Severity?

Nutritional intervention may improve migraine severity: a pilot study

Dietary carbohydrate composition is associated with polycystic ovary syndrome: a case–control study

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