Poorly differentiated adenocarcinoma of the rectum in a nephrotic patient with focal segmental glomerulosclerosis

Abstract

We report herein a case of poorly differentiated adenocarcinoma of the rectum occurring in a nephrotic patient with focal segmental glomerulosclerosis. The neoplasm which first appeared to be a submucosal tumor occurred in a 29-year old Japanese man with a nephrotic syndrome for 2 years and 6 months. Autopsy disclosed a large tumor located between the rectum and urinary bladder. Renal specimens showed changes consistent with focal segmental glomerulosclerosis.

Glomerulosclerosis: A paraneoplastic phenomenon?

“…Focal segmental glomerulosclerosis and its association with solid tumours is even rarer. It has been reported in association with poorly differentiated adenocarcinoma of the rectum, 6 malignant mesothelioma 7 and poorly differentiated gall bladder adenocarcinoma 8 . In this paper we provide three case reports of FSGS being associated with, and predating, metastatic melanoma, metastatic sarcoma and adenocarcinoma of the oesophagus.…”