The Association of Non–Small-Cell Lung Cancer, Focal Segmental Glomerulosclerosis, and Platelet Dysfunction

Lin, Fang Chi; Chen, Jinn Yang; Yang, An Hang; Chang, Shi Chuan

doi:10.1097/00000441-200209000-00008

Cited by 20 publications

(12 citation statements)

References 12 publications

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“…Crescentic glomerulonephritis due to tumor-associated immune complex glomerulonephritis has occurred with renal cell carcinoma, and is a rarity. [6] Focal segmental glomerulosclerosis has been reported with hematological malignancies, non-small cell lung cancer, [7] and Hodgkin's disease. [8] Linear IgA bullous disease is also known to occur in association with malignancies.…”

Section: Resultsmentioning

confidence: 99%

Nephrotic Syndrome as a Complication of Intravesical BCG Treatment of Transitional Cell Carcinoma of Urinary Bladder

et al. 2007

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Nephrotic syndrome can be associated with various neoplasms, especially solid tumors and lymphomas. This patient presented with painless hematuria of transitional cell carcinoma of urinary bladder, underwent transurethral resection, but developed recurrence 16 months later. Repeat resection was done and intravesical Bacillus Calmette-Guerin (BCG) injections were started. After six months, the patient developed hypertension and nephrotic syndrome with a biopsy revealing membranous glomerulonephritis, though there was no radiological evidence of tumor. This is the first case of nephrotic syndrome with intravesical BCG instillation in a bladder carcinoma patient.

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Section: Resultsmentioning

confidence: 99%

Nephrotic Syndrome as a Complication of Intravesical BCG Treatment of Transitional Cell Carcinoma of Urinary Bladder

et al. 2007

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“…To our knowledge, only one case of FSGS in a patient with lung cancer has been reported in the English literature. Lin et al (2) described the case of a 61-year-old man with non-small cell lung cancer (2). In that case, paraneoplastic nephrotic syndrome caused by FSGS was improved by radiotherapy targeting the primary lung tumor.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, focal segmental glomerulosclerosis (FSGS) is extremely rare among paraneoplastic nephrotic syndromes. To the best of our knowledge, only one case of FSGS underlying lung cancer has been reported (2). We herein describe the case of a patient with lung adenocarcinoma complicated by FSGS as a paraneoplastic syndrome who obtained a partial response following the administration of standard-dose carboplatin-containing chemotherapy.…”

Section: Introductionmentioning

confidence: 94%

“…Among paraneoplastic syndromes, renal complications, namely paraneoplastic nephrotic syndrome, are relatively rare in patients with lung cancer (2). The glomerular lesions of paraneoplastic nephrotic syndrome usually present as membranous nephropathy, minimal-change disease or membranoproliferative glomerulonephritis, the most common of which is membranous nephropathy (3,4).…”

Section: Introductionmentioning

confidence: 99%

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Paraneoplastic Focal Segmental Glomerulosclerosis in a Patient with Lung Adenocarcinoma

et al. 2013

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Focal segmental glomerulosclerosis (FSGS) is extremely rare among paraneoplastic nephrotic syndromes. We herein report a case of lung adenocarcinoma with nephrotic syndrome caused by paraneoplastic FSGS. A 68-year-old man visited our hospital for an evaluation of a right hilar mass on chest radiography and supraclavicular lymphadenopathy. Because an aspiration biopsy of the supraclavicular lymph node revealed adenocarcinoma, the patient was diagnosed with lung adenocarcinoma. He also had nephrotic syndrome, and the pathological findings of the renal biopsy demonstrated FSGS. Standard-dose carboplatin-containing chemotherapy led to a partial response for lung cancer and improved the patient's nephrotic syndrome without causing any adverse renal effects.

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“…The association of nonrenal neoplasia with glomerular disease in general, typically membranous glomerulonephritis, is well known [6]. FSGS has been observed secondary to non-small-cell lung cancer [7] and Wilms tumor [8]. In addition, Magyarlaki et al [9] reported that in a series of 60 patients with renal cell carcinomas, 5 (8%) were found to have FSGS and another 11 (18%) had IgA nephropathy.…”

Section: Discussionmentioning

confidence: 99%

Focal Segmental Glomerulosclerosis in Kidney Resected for Renal Cell Carcinoma

2005

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A diagnosis of renal dysfunction is usually made on the basis of clinical, biochemical, radiologic, and renal tissue analysis. Accurate diagnosis often requires a renal biopsy, but that procedure is contraindicated in certain clinical circumstances, particularly in patients who have only one kidney. We describe a patient who previously had undergone left nephrectomy for a renal clear cell carcinoma, in whom the diagnosis of focal segmental glomerulosclerosis was made on retrospective analysis of remnant renal tissue from the patient's nephrectomy specimen.

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The Association of Non–Small-Cell Lung Cancer, Focal Segmental Glomerulosclerosis, and Platelet Dysfunction

Cited by 20 publications

References 12 publications

Nephrotic Syndrome as a Complication of Intravesical BCG Treatment of Transitional Cell Carcinoma of Urinary Bladder

Nephrotic Syndrome as a Complication of Intravesical BCG Treatment of Transitional Cell Carcinoma of Urinary Bladder

Paraneoplastic Focal Segmental Glomerulosclerosis in a Patient with Lung Adenocarcinoma

Focal Segmental Glomerulosclerosis in Kidney Resected for Renal Cell Carcinoma

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