Poorly differentiated squamous cell carcinoma arising within a lesion of discoid lupus erythematosus in an African-American woman

Gamble, Misty; Tocci, Elizabeth; Venna, Suraj; Reserva, Jeave; Radfar, Arash; Dugan, Elizabeth M.

doi:10.1016/j.jdcr.2015.03.009

Cited by 12 publications

(10 citation statements)

References 9 publications

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“…With regard to skin tumor occurrence, an increased risk to develop cutaneous squamous cell carcinoma (cSCC) especially in black patients with DLE was observed 2,3 . Nevertheless more recent papers reported that DLE is not associated with a higher risk to develop cSCC compared to the general population, 11 cSCC occurring in DLE lesions is rare and in black‐skin DLE lesions is even rarer 12 . DLE, or other inflammatory diseases, are supposed to be associated with an increased risk of skin cancer related to the immunosuppressive therapy used to treat these conditions rather than to immune dysregulation.…”

Section: Discussionmentioning

confidence: 99%

“…2,3 Nevertheless more recent papers reported that DLE is not associated with a higher risk to develop cSCC compared to the general population, 11 cSCC occurring in DLE lesions is rare and in black-skin DLE lesions is even rarer. 12 DLE, or other inflammatory diseases, are supposed to be associated with an increased risk of skin cancer related to the immunosuppressive therapy used to treat these conditions rather than to immune dysregulation. On this matter, MMF was compared with Azathioprine in a cohort of solid organ transplant recipients to assess the risk of skin cancer, concluding that MMF use is associated with a lower risk of cSCC.…”

Section: Dle Lesions Can Have Devastating Cosmetic and Functional Effects When Occurring On Volar Skinmentioning

confidence: 99%

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Refractory palmo‐plantar discoid lupus erythematosus successfully treated with mycophenolate mofetil: Unusual localization and literature review

Bardazzi

Gallo

Loi

et al. 2021

Dermatologic Therapy

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Palmo-plantar lesions in discoid lupus erythematosus (DLE) can be considered a very distinct rarity, generally refractory to conventional treatments. We present a 47-yearold African female patient with a 6-month clinical history of palm and soles erosions. Clinical examination revealed painful multiple, well defined, erosions with an erythematous and scaly central area and peripherical post-inflammatory hyperchromic border bilaterally distributed on the palmo-plantar surfaces. Pterygium inversum unguis involved all nails of both hands. Histological analysis and direct immunofluorescence study confirmed palmo-plantar DLE. Therapy with mycophenolate mofetil (MMF) was initiated with a progressive clearing of palmo-plantar lesions and a drastic reduction of pain. Therapy was well tolerated, neither side effects nor altered laboratory investigations were observed. Our case and literature review confirm that MMF may be an effective approach for the management of refractory palmo-plantar DLE with a safer profile than Azathioprine regarding adverse effects and cutaneous malignancies risk.

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Section: Discussionmentioning

confidence: 99%

Section: Dle Lesions Can Have Devastating Cosmetic and Functional Effects When Occurring On Volar Skinmentioning

confidence: 99%

Refractory palmo‐plantar discoid lupus erythematosus successfully treated with mycophenolate mofetil: Unusual localization and literature review

Bardazzi

Gallo

Loi

et al. 2021

Dermatologic Therapy

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“…16 Alguns autores apresentam que o carcinoma espinocelular pode evoluir a partir de lesões cutâneas discóides, apesar de raramente. 4,16,17 Em contraste, um estudo de coorte com 155 pacientes com LEC apontou que em comparação com o grupo controle, os pacientes com LEC não apresentaram um risco aumentado para câncer. 18 O aspecto clínico do LED em lesões orais são áreas com ulcerações centrais ou eritematosas e geralmente circundadas por estrias brancas, semelhantes ao LPO.…”

Section: Relato De Casounclassified

Múltiplas manifestações orais em lúpus eritematoso cutâneo

Cusini

Reis

Pigatti

et al. 2021

hu rev

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Introdução: Lúpus eritematoso cutâneo crônico (LECC) é uma doença inflamatória autoimune, sendo características as lesões em pele. As manifestações intraorais são descritas e podem apresentar aspecto semelhante a outras lesões de origem autoimune, destacando a necessidade de avaliação e diagnóstico das lesões em mucosa oral pelo cirurgião-dentista. Objetivo: Apresentar um caso de lúpus eritematoso cutâneo com múltiplas manifestações orais, sem lesões em pele simultâneas, com enfoque em exames clínicos, histopatológicos e sorológicos para investigação de envolvimento sistêmico. Relato de Caso: Mulher de 54 anos, com histórico de lúpus, compareceu a clínica com uma lesão de aspecto liquenóide em lábio inferior e no palato duro observou-se uma área extensa, eritematosa e assintomática, com linhas brancas reticulares. Gengivite descamativa foi observada em maxila e mandíbula. Em mucosa jugal havia áreas liquenóides e pigmentadas. Biópsia incisional foi realizada no palato duro e a análise histopatológica revelou fragmento da mucosa bucal exibindo hiperqueratose e degeneração focal da camada basal. Foram solicitados exames complementares os quais descartaram envolvimento sistêmico. Conclusão: Esse caso destaca a diversidade de manifestações orais em paciente com lúpus e a importância do exame de mucosa oral, mesmo na ausência de lesões em pele, que são mais comuns. É fundamental a participação do cirurgião-dentista na esquipe multidisciplinar dos pacientes em tratamento de lúpus eritematoso.

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“…There have been a number of case reports, primarily of dark-skinned individuals (skin phototype V and VI), describing the occasional occurrence of squamous cell carcinoma in DLE patients, with metastatic spread observed in 20-40 % of cases [2][3][4][5]. Unlike this evidence from case reports, however, a recent cohort study of 155 patients with cutaneous LE failed to show an increased risk of malignancies, including skin cancer, compared to the general population [6].…”

Section: Casementioning

confidence: 99%

Cutaneous squamous cell carcinoma as a complication of discoid lupus erythematosus

Paschos

Lehmann

Hofmann

2019

J Deutsche Derma Gesell

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Poorly differentiated squamous cell carcinoma arising within a lesion of discoid lupus erythematosus in an African-American woman

Cited by 12 publications

References 9 publications

Refractory palmo‐plantar discoid lupus erythematosus successfully treated with mycophenolate mofetil: Unusual localization and literature review

Refractory palmo‐plantar discoid lupus erythematosus successfully treated with mycophenolate mofetil: Unusual localization and literature review

Múltiplas manifestações orais em lúpus eritematoso cutâneo

Cutaneous squamous cell carcinoma as a complication of discoid lupus erythematosus

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