POPs and Skin

Leijs, Marike; Koppe, Janna G.; Kraus, Thomas; Baron, Jens Malte

doi:10.1007/978-3-319-43102-4_10

Cited by 4 publications

(4 citation statements)

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“…Eight pesticides, two industrial chemicals, and two unanticipated industrial byproducts, together known as "the dirty twelve," are utilized in home items including insecticides, solvents, and even medications, as well as in industry and agriculture. [6][7] Furthermore, the brominated flame-retardants and polycyclic aromatic hydrocarbons are among the "nasty nine" (BFRs). [8] Because of its harmful, bio-accumulative and persistent environmental characteristics, chloronaphthalenes, the majority of which are semi-volatile, were added to the list of prohibited POPs during the seventh meeting of the Conference of the Parties to the Stockholm Convention in May 2015.…”

Section: Introductionmentioning

confidence: 99%

“…The first twelve “Dirty Dozen,” which are considered to be very dangerous substances, as well as the “Nasty Nine” also include POPs. Eight pesticides, two industrial chemicals, and two unanticipated industrial by‐products, together known as “the dirty twelve,” are utilized in home items including insecticides, solvents, and even medications, as well as in industry and agriculture [6–7] . Furthermore, the brominated flame‐retardants and polycyclic aromatic hydrocarbons are among the “nasty nine” (BFRs) [8] .…”

Section: Introductionmentioning

confidence: 99%

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Organochlorine detection on transition metals (X=Zn, Ti, Ni, Fe, and Cr) anchored fullerenes (C₂₃X)

et al. 2023

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Herein, the Kohn‐Sham K density functional theory (DFT) approach has been employed to investigate the adsorption and sensing efficacy of C23X (X=Zn, Ti, Ni, Fe, and Cr) nanoclusters towards a selected organochlorine derivative (chloronaphthalene). CLN@C23Ti (T1) and CLN@C23Cr (C1) complexes indicated stronger adsorption as confirmed by the adsorption energy values of −68.3384 and −49.3581 Kcal/mol. Also, higher change in charge transfers of −1.7134 and −1.0414 observed in C1 and T1 complexes respectively and this result was further strengthened by dipole moment analysis. C23Ti and C23Cr surfaces reflect higher dipole moment of 5.7126 and 4.7552 D respectively, indicating higher charge separation and stronger interactions upon the adsorption of chloronaphthalene (CLN). Rich blue color possessed by all complexes in the 3D isosurface of the Reduced Density Gradient (RDG) plots, signifies the presence of a very strong force of attraction as a result of hydrogen bond interaction. These results are consistent with the topological analysis and those of sensing mechanisms, thus, leading to a conclusive scientific report that C23Ti and C23Cr nanoclusters exhibit relatively better sensing efficacy for the detection of CLN. Hence, it can be employed in coupling future sensor device for CLN molecule.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Organochlorine detection on transition metals (X=Zn, Ti, Ni, Fe, and Cr) anchored fullerenes (C₂₃X)

et al. 2023

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“…Cutaneous symptoms are the hallmark and most obvious signs of exposure to these compounds [ 11 ]. As an example, during the Yusho incident (Japan, 1968), where humans were exposed to PCB contaminated oil, a disease characterized by acne-like eruptions, pigmentation of the skin, and eye discharge appeared.…”

Section: Introductionmentioning

confidence: 99%

Upregulation of CCL7, CCL20, CXCL2, IL-1β, IL-6 and MMP-9 in Skin Samples of PCB Exposed Individuals—A Preliminary Study

Leijs

Fietkau

Schettgen

et al. 2021

IJERPH

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Polychlorinated biphenyls (PCBs) are well known immunotoxic and carcinogenic compounds. Although cutaneous symptoms are the hallmark of exposure to these compounds, exact pathophysiologic mechanisms are not well understood. We took skin biopsies from moderately high PCB exposed workers (n = 25) after an informed consent and investigated the expression of immunological markers such as CCL-7, CCL-20, CXCL2, IL-1β and IL-6, as well as the matrix metalloproteinase MMP-9, EPGN and NRF2 by RT-qPCR, and compared expression levels with plasma PCB levels. Statistical analyses showed a significant correlation between CCL-20, CXCL2, IL-6, IL-1β, CCL-7 and MMP-9 and PCB serum levels. EPGN and NRF2 were not correlated to PCB levels in the blood. We found a significant correlation of genes involved in autoimmune, auto-inflammatory and carcinogenesis in skin samples of PCB exposed individuals with elevated plasma PCB levels. Confirmation of these findings needs to be performed in bigger study groups and larger gen-sets, including multiple housekeeping genes. Further study needs to be performed to see whether a chronical exposure to these and similar compounds can cause higher incidence of malignancies and inflammatory disease.

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“…benzo(a)pyrene – or halogenated hydrocarbons including several persistent organic pollutants (POPs) – e.g. 2,3,7,8‐tetrachlorodibenzo‐ p ‐dioxin (TCDD) . In the meantime, it ruled out that other ligands of this receptor such as kynurenine – an endogenous tryptophan metabolite – or 6‐formylindolo[3,2‐b]carbazole (FICZ) which is generated from the chromophore tryptophan under the influence of UV light .…”

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confidence: 99%

Aryl hydrocarbon receptor signalling in the skin and adverse vemurafenib effects

Merk

2018

Acad Dermatol Venereol

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POPs and Skin

Cited by 4 publications

References 109 publications

Organochlorine detection on transition metals (X=Zn, Ti, Ni, Fe, and Cr) anchored fullerenes (C₂₃X)

Organochlorine detection on transition metals (X=Zn, Ti, Ni, Fe, and Cr) anchored fullerenes (C₂₃X)

Upregulation of CCL7, CCL20, CXCL2, IL-1β, IL-6 and MMP-9 in Skin Samples of PCB Exposed Individuals—A Preliminary Study

Aryl hydrocarbon receptor signalling in the skin and adverse vemurafenib effects

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POPs and Skin

Cited by 4 publications

References 109 publications

Organochlorine detection on transition metals (X=Zn, Ti, Ni, Fe, and Cr) anchored fullerenes (C23X)

Organochlorine detection on transition metals (X=Zn, Ti, Ni, Fe, and Cr) anchored fullerenes (C23X)

Upregulation of CCL7, CCL20, CXCL2, IL-1β, IL-6 and MMP-9 in Skin Samples of PCB Exposed Individuals—A Preliminary Study

Aryl hydrocarbon receptor signalling in the skin and adverse vemurafenib effects

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Product

Resources

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Organochlorine detection on transition metals (X=Zn, Ti, Ni, Fe, and Cr) anchored fullerenes (C₂₃X)

Organochlorine detection on transition metals (X=Zn, Ti, Ni, Fe, and Cr) anchored fullerenes (C₂₃X)