Population and familial study of histocompatibility antigens in acute leukemias and aplastic anemia

Sell, Ana Maria; Biral, Ana Cristina Westphal Cheraria; Oliveira, Vanessa Cristina de; Brandalise, Sílvia Regina; Magna, Luiz Alberto; Kraemer, Markus

doi:10.1016/0198-8859(96)84801-4

Cited by 3 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the absence of a healthy control population for the minority group, we elected to use as controls HLA typing results from a cohort of patients with pediatric leukemia and their parents who were partly reported elsewhere (13). The rational for selecting these controls was, as fully detailed elsewhere (13), that (i) family analysis enables clear assignment of haplotypes by the mode of inheritance; (ii) no difference was found in the repartition of alleles and haplotypes among the inherited and the non-inherited haplotypes in patient families meaning that patient disease was not associated with HLA gene polymorphism in our series, in agreement with the most recent data published by others on the association between HLA and acute leukemia (14) and (iii) the two control groups were precisely matched with regard to ethnicity, as well as for cases.…”

Section: Controlssupporting

confidence: 91%

HLA‐associated genetic resistance and susceptibility to type I diabetes in French North Africans and French natives

et al. 2007

View full text Add to dashboard Cite

The distribution of human leukocyte antigen (HLA)-DRB1-DQA1-DQB1 haplotypes was analyzed separately in two distinct French ethnic groups with type I diabetes (T1D), i.e. French North African migrants (n= 64, mean age at diagnosis = 8.25 years) and ancient French natives (n= 60, mean age at diagnosis = 7.42 years). HLA associations were determined by calculating odds ratios (ORs) between patients and two ethnic-matched control populations. Results show highly similar ORs for the conservative DRB1*0301-DQA1*0501-DQB1*0201 haplotype of susceptibility (OR: 3.22 and 3.93 in migrants and natives, respectively) and the DRB1*1501-DQA1*0102-DQB1*0602 haplotype of resistance (OR: 0.05 and 0.03, respectively). In contrast, among the more variable DRB1*04-DQB1*0302 haplotypes of susceptibility, the DRB1*0402 (OR: 3.10 and 32.84) and 0405 (OR: 5.90 and 16.25, respectively) were associated with T1D in migrants and natives, whereas an increase of DRB1*0401, a rare allele in migrants, was significant in natives only. Also, among the DRB1*11-DQA1*0505-DQB1*0301 haplotypes of resistance, the OR observed for DRB1*1104-DQA1*0505-DQB1*0301, common in migrants, was lower (OR: 0.08) than for DRB1*1101-DQA1*0505-DQB1*0301 (OR: 0.32), common in natives. How DRB1*11 subtypes might affect differently the risk conferred by DQA1*0505-DQB1*0301 will be discussed.

show abstract

Section: Controlssupporting

confidence: 91%

HLA‐associated genetic resistance and susceptibility to type I diabetes in French North Africans and French natives

et al. 2007

View full text Add to dashboard Cite

show abstract

“…This patient population was selected because of the following reasons: (1) Members of the immediate family were also HLA typed, so that haplotypes could clearly be assigned by the mode of inheritance; (2) Residual blood samples from family members were available for further HLA genotyping for the purpose of the present study; and (3) No difference was found in the repartition of alleles among inherited and noninherited haplotypes in patient families. This latter factor ensured that patient disease was not associated with HLA gene polymorphism in our series (not shown), in accordance with the most recent published data on the associations between HLA and acute leukemia [17]. Therefore, four haplotypes per family (i.e., two noninherited in addition to the two inherited by the patients) were included in the present study to enlarge the size of the sample.…”

Section: Materials and Methods Population Samplessupporting

confidence: 77%

HLA Alleles and Haplotypes in French North African Immigrants

et al. 2006

View full text Add to dashboard Cite

“…14 This is similar to the results from the present study, where the frequency of HLA-DRB1*15 was significantly higher in individuals with AML than in controls, and with the results obtained by Oguz et al 13 In another study, HLA-DR5 (which contains the DR11 and DR12 subgroups) was a potential marker for AML. 8 Although the association between the HLA-DRB1*11 allele and AML has been described previously, no significant association was detected in the present study.…”

Section: Discussioncontrasting

confidence: 66%

The Frequency of HLA Class I and II Alleles in Turkish Childhood Acute Leukaemia Patients

et al. 2010

View full text Add to dashboard Cite

In this study, blood samples were taken from 200 patients with childhood acute leukaemias, including acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML), and from 100 healthy volunteers (controls). The frequency of the human leucocyte antigen (HLA)-DRB1*04 allele was significantly higher, and the frequencies of the HLA-A23 and HLA-B7 antigens were significantly lower, in patients with ALL compared with controls. Among patients with AML, the frequency of the HLA-B49 antigen and the HLA-DRB1*15 allele were significantly higher, whereas the frequencies of the HLA-A11 and HLA-B38 antigens were significantly lower compared with controls. The frequency of the HLA-DRB1*04 allele was also significantly higher in male patients with ALL and AML, whereas the HLA-DRB1*13 allele was found significantly less frequently in male AML and female ALL patients than in controls. To date, this is the only study to evaluate the associations between HLA molecules and leukaemia in a Turkish population with acute childhood leukaemia.

show abstract

Population and familial study of histocompatibility antigens in acute leukemias and aplastic anemia

Cited by 3 publications

References 0 publications

HLA‐associated genetic resistance and susceptibility to type I diabetes in French North Africans and French natives

HLA‐associated genetic resistance and susceptibility to type I diabetes in French North Africans and French natives

HLA Alleles and Haplotypes in French North African Immigrants

The Frequency of HLA Class I and II Alleles in Turkish Childhood Acute Leukaemia Patients

Contact Info

Product

Resources

About