Population aspects of warfarin resistance in the Brown rat, Rattus norvegicus

Greaves, J. H.; Rennison, B. D.

doi:10.1111/j.1365-2907.1973.tb00166.x

Cited by 23 publications

(13 citation statements)

References 5 publications

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“…Such selection and resistance is well documented in populations of rats and mice (e.g. Greaves and Rennison, 1973;Pelz et al 1995) many of which have for decades been frequently poisoned with anticoagulant toxins (Greaves et at. 1976).…”

Section: Physiological Resistancementioning

confidence: 99%

Implications of prefeeding for the development of bait aversions in brushtail possums (Trichosurus vulpecula)

Moss¹,

O'Connor²,

Hickling³

1998

Wildl. Res.

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of a thesis submitted in partial fulfilment of the requirements for the Degree of Master of Science Implications of prefeeding for the development of bait aversions in brushtail possums (Trichosurus vulpecula) by Zane N. Moss The first cage trial determined the effects of prefeeding on aversion development. Three treatment groups received for 7 days either i) no prefeed ii) plain prefeed, or iii) dyed and lured prefeed baits. Each possum then ingested a sub-lethal 1080 bait. Seven days later, the possums were tested for development of an aversion towards a 1080 bait, a prefeed bait, and a prefeed bait containing brodifacoum. Most (96%) non-prefed possums became averse to the 1080 bait, compared with only 55% and 9% of the two prefed groups.Similarly, over 90% of the non-prefed possums were averse to prefeed and brodifacoum baits, compared to <15% of the prefed possums. The trial also showed that novelty has an influence on possums' aversion development; as prefeed and toxic baits became more similar (i.e. the more cues shared), fewer prefed possums were able to distinguish between the two after sub-lethal poisoning and so few developed aversions.The second cage trial examined the influence of bait cues and prefeeding duration on possums' development of aversion. Three main treatment groups received either i) dyed, ii) cinnamon lured, or iii) dyed and lured prefeed baits, for either 1 or 7 days.iii Mter sub-lethal poisoning possums were tested for aversion towards a 1080 bait and a prefeed bait. Once again the influence of familiarity was apparent, with only 34% averse to the toxic bait, significantly less than for non-prefed possums (cf. trial one). Dye seemed to provide relatively weak cues linking prefeed and toxic bait, with 7 days prefeeding required to inhibit aversion development. In contrast, cinnamon appeared to provide relatively strong olfactory and/or taste cues linking prefeed and toxic baits, with one exposure to cinnamon lured prefeed sufficient to inhibit aversion development. As in the first trial, most of the possums that developed aversion to the toxic bait did not generalise this aversion to the prefeed bait. Some possums were seemingly able to detect 0.08% 1080, despite it being' masked' with cinnamon oil.The field trial aimed to validate results of the cage trials and to examine whether possums preferentially associate certain cues with poisoning. Two treatment groups received either cinnamon lured baits, or apples, for 3 weeks. Mter sub-lethal poisoning possums were tested for aversion towards a non-toxic prefeed bait, a dyed non-toxic bait, a toxic bait, and a dyed toxic bait, all of which contained cinnamon. Once again most non-prefed possums developed generalised aversions, avoiding all cereal baits. In contrast, prefed possums consumed familiar prefeed baits, but avoided all other baits. This demonstrated that possums could detect both dye and 1080 in a cinnamon-lured bait. This result also suggests that extended prefeeding may enable possums to distinguish between prefeed a...

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Section: Physiological Resistancementioning

confidence: 99%

Implications of prefeeding for the development of bait aversions in brushtail possums (Trichosurus vulpecula)

Moss¹,

O'Connor²,

Hickling³

1998

Wildl. Res.

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“…But no information is available on such crucial things as the comparative sizes of the bottlenecks that each population probably went through soon after introduction. The appearance of warfarin-resistant strains of R. norvegicus (e.g., Greaves and Rennison 1973) suggests that that invader may once again increase. But the pattern of greater success of the latter in both Australia and New Zealand argues against either of these hypothesis.…”

Section: Sparrowsmentioning

confidence: 99%

Ecology of Biological Invasions of North America and Hawaii

Mooney¹,

Drake²

1986

Ecological Studies

319

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“…to anticoagulant rodenticides has received considerable study since it was discovered in the early 1960s (Drummond 1966). The speed of spread of resistance was investigated (Greaves and Rennison 1973) and the pleiotropic effects of the possession of the Welsh anticoagulant resistance gene, involving an increased requirement for dietary vitamin K, was also studied (Partridge 1979). Subsequently, Welsh farms infested with resistant rats were used to check the field efficacy of the majority of the anticoagulant rodenticides now in common use (Rennison and Hadler 1975;Rennison and Dubock 1978;Richards 1981;Buckle 1986).…”

Section: Introductionmentioning

confidence: 99%

Relationship between resistance factors and treatment efficacy when bromadiolone was used against anticoagulant-resistant Norway rats (Rattus norvegicusBerk.) in Wales

Buckle

Endepols

Prescott

2007

International Journal of Pest Management

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We investigated the relationship between the severity and incidence of resistance among Norway rats (Rattus norvegicus) on a farm in Wales and the subsequent outcome of a practical rodent control operation. Bromadiolone resistance factors were estimated for rats trapped on the farm using the blood clotting response test, and were found to be 2 to 3 for male rats and approximately 6 for females. The incidence of resistance in the rat population was high. Infestation size was estimated by census baiting and tracking, and was found to be substantial, with a maximum of 6.5 kg of bait being eaten on a single night. A proprietary rodenticide (Deadline TM ), containing 0.005% bromadiolone, was used to control the infestation. The duration of baiting was 35 days and, according to the two methods of assessment used, treatment success was in the region of 87 and 93%. No evidence was observed of a significant impact of resistance on the rat control operation, and the remaining rats of this very heavy infestation would probably have been controlled if baiting had continued for longer.

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Population aspects of warfarin resistance in the Brown rat, Rattus norvegicus

Cited by 23 publications

References 5 publications

Implications of prefeeding for the development of bait aversions in brushtail possums (Trichosurus vulpecula)

Implications of prefeeding for the development of bait aversions in brushtail possums (Trichosurus vulpecula)

Ecology of Biological Invasions of North America and Hawaii

Relationship between resistance factors and treatment efficacy when bromadiolone was used against anticoagulant-resistant Norway rats (Rattus norvegicusBerk.) in Wales

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