Population balance modeling: application in nanoparticle formation through rapid expansion of supercritical solution

Bagheri, Hamidreza; Hashemipour, Hassan; Ghader, Sattar

doi:10.1007/s40571-019-00257-w

Cited by 32 publications

(4 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nanoparticles are formed by several processes, including nucleation and growth. Therefore, the population balance model was used to model the formation of nanoparticles ( 31 ). The general population balance method is written in term of particle disregarding aggregation and breakage terms is established as follows ( 32 ):…”

Section: Methodsmentioning

confidence: 99%

Chitosan/tripolyphosphate nanoparticles in active and passive microchannels

Akbari

Rahimi

2021

Research in Pharmaceutical Sciences

View full text Add to dashboard Cite

Background and purpose: In recent years, the interest in chitosan nanoparticles has increased due to their application, especially in drug delivery. The main aim of this work was to find a suitable method for simulating pharmaceutical nanoparticles with computational fluid dynamics (CFD) modeling and use it for understanding the process of nanoparticle formation in different types of microchannels. Experimental approach: Active and passive microchannels were compared to find the advantages and disadvantages of each system. Twenty-eight experiments were done on microchannels to quantify the effect of 4 parameters and their interactions on the size and polydispersity index (PDI) of nanoparticles. CFD was implemented by coupling reactive kinetics and the population balance method to simulate the synthesis of chitosan/tripolyphosphate nanoparticles in the microchannel. Findings/Results: The passive microchannel had the best performance for nanoparticle production. The most uniform microspheres and the narrowest standard deviation (124.3 nm, PDI = 0.112) were achieved using passive microchannel. Compared to the active microchannel, the size and PDI of the nanoparticles were 28.7% and 70.5% higher for active microchannels, and 55.43% and 105.3% higher for simple microchannels, respectively. Experimental results confirmed the validity of CFD modeling. The growth and nucleation rates were determined using the reaction equation of chitosan and tripolyphosphate. Conclusion and implications: CFD modeling by the proposed method can play an important role in the prediction of the size and PDI of chitosan/tripolyphosphate nanoparticles in the same condition and provide a new perspective for studying the production of nanoparticles by numerical methods.

show abstract

Section: Methodsmentioning

confidence: 99%

Chitosan/tripolyphosphate nanoparticles in active and passive microchannels

Akbari

Rahimi

2021

Research in Pharmaceutical Sciences

View full text Add to dashboard Cite

show abstract

“…Various techniques based on SCF technology are recommended to reduce the particle size of drugs. The solubility of the drug in scCO 2 is one of the most important factors in selecting an adequate SCF-based technique . The industrialization and commercialization of products derived from processes based on SCF require a thorough understanding of the quality, purity, extractability, and solubility of these materials .…”

Section: Introductionmentioning

confidence: 99%

“…The solubility of the drug in scCO 2 is one of the most important factors in selecting an adequate SCF-based technique. 41 The industrialization and commercialization of products derived from processes based on SCF require a thorough understanding of the quality, purity, extractability, and solubility of these materials. 42 The solubility of drugs in SCF is critical for the selection and design of pharmaceutical processes.…”

Section: Introductionmentioning

confidence: 99%

Solubility Measurement and Correlation of Alprazolam in Carbon Dioxide with/without Ethanol at Temperatures from 308 to 338 K and Pressures from 120 to 300 bar

Sajadian,

Bagheri,

Gurikov

et al. 2024

J. Chem. Eng. Data

Self Cite

View full text Add to dashboard Cite

This research investigated the solubility of alprazolam in supercritical carbon dioxide (scCO 2 ) with the addition of ethanol as a cosolvent. The solubility was examined at various pressures (ranging from 120 to 300 bar) and temperatures (ranging from 308 to 338 K). The solubility of alprazolam in scCO 2 ranged from 0.027 × 10 −4 to 0.632 × 10 −4 . When ethanol was used as a cosolvent, the solubility increased to a range of 0.157 × 10 −4 to 1.660 × 10 −4 (with 1 mol % ethanol) and 0.449 × 10 −4 to 3.167 × 10 −4 (with 3 mol % ethanol). Under the specified operating parameters, the highest solubility of alprazolam was achieved in the ternary system (with 3 mol % ethanol) at 120 bar and 338 K. This solubility was 16.63 times higher than when using pure scCO 2 under the same circumstances. Several semiempirical correlations were used to compute the solubility of alprazolam in supercritical carbon dioxide. These models yielded similar average absolute relative deviations ranging from 7.0 to 8.40%. The findings demonstrated the superiority of the Kumar−Johnston model in binary systems (with an average absolute relative deviation of 7.0%) and the Garlapati−Madras model in ternary systems (with an average absolute relative deviation of 6.19%) compared to alternative models.

show abstract

“…Such nano fillers are used in rubber formulations in order to improve the physical and mechanical properties. [7][8][9] Nano fillers have indicated a great potential to improve tyres properties. Compared to conventional filler, the high interfacial surface area of nanofillers lessen the quantity of filler required and thus reduces the specific gravity of the compound and heat generation that ultimately lead to the high performance of tyre and its better fuel efficiency.…”

Section: Introductionmentioning

confidence: 99%

Production of Bitumen Modified with Low-Molecular Organic Compounds from Petroleum Residues.4. Determining the Optimal Conditions for Tar Modification with Formaldehyde and Properties of the Modified Products

Gunka¹,

Bilushchak²,

Prysiazhnyi³

et al. 2022

ChChT

View full text Add to dashboard Cite

The effect of factors on the process of chemical modification of tar with formaldehyde using a sulfuric acid as the catalyst has been studied. By using experimental results, the adequate statistical-mathematical (ESM) model has been developed. Based on this model, the optimal values on the process of chemical modification of tar with formaldehyde using a sulfuric acid as the catalyst have been identified, bringing about optimal penetration value and softening point of the modified tars. Data predicted on the basis of the ESM model were compared with empirical evidence about modified tars preparation.

show abstract

Population balance modeling: application in nanoparticle formation through rapid expansion of supercritical solution

Cited by 32 publications

References 41 publications

Chitosan/tripolyphosphate nanoparticles in active and passive microchannels

Chitosan/tripolyphosphate nanoparticles in active and passive microchannels

Solubility Measurement and Correlation of Alprazolam in Carbon Dioxide with/without Ethanol at Temperatures from 308 to 338 K and Pressures from 120 to 300 bar

Production of Bitumen Modified with Low-Molecular Organic Compounds from Petroleum Residues.4. Determining the Optimal Conditions for Tar Modification with Formaldehyde and Properties of the Modified Products

Contact Info

Product

Resources

About