Population-Based Prevalence of Gastrointestinal Abnormalities at Colon Capsule Endoscopy

Vuik, Fanny E.; Nieuwenburg, Stella A.; Moen, Sarah; Schreuders, Eline H.; Pool, M. Oudkerk; Peterse, Elisabeth F. P.; Spada, Cristiano; Epstein, Owen; Fernández-Urién, Ignacio; Hofman, Albert; Kuipers, Ernst J.; Spaander, Manon C.W.

doi:10.1016/j.cgh.2020.10.048

Cited by 10 publications

(8 citation statements)

References 24 publications

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“…This study was embedded in the Rotterdam Study, an ongoing prospective population-based cohort study in Rotterdam, the Netherlands ( 20 ). A subset of participants with ages ranging from 50 to 75 years underwent CCE, as described in more detail elsewhere ( 21 ). This study was approved by the Institutional Review Board of Erasmus MC (registration number MEC-2015-453).…”

Section: Methodsmentioning

confidence: 99%

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Predictors of Gastrointestinal Transit Times in Colon Capsule Endoscopy

Moen

Vuik

Voortman

et al. 2022

Clin Transl Gastroenterol

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INTRODUCTION: Optimizing the accuracy of colon capsule endoscopy (CCE) requires high completion rates.To prevent incomplete CCE, we aimed to identify predictors associated with slow CCE transit times. METHODS:In this population-based study, participants received CCE with a split-dose polyethylene glycol bowel preparation and booster regimen (0.5 L oral sulfate solution and 10 mg metoclopramide if capsule remained in stomach for > 1 hour). The following predictors were assessed: age, sex, body mass index (BMI), smoking, coffee and fiber intake, diet quality, physical activity, dyspeptic complaints, stool pattern, history of abdominal surgery, medication use, and CCE findings. Multivariable logistic and linear regressions with backward elimination were performed.

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Section: Methodsmentioning

confidence: 99%

“…Stomach protectors included proton pump inhibitors, H2 antagonists, antiemetics, and gastric acid binders. For history of abdominal surgery, it should be noted that participants were not included when they had prior abdominal surgery likely to cause bowel obstruction ( 21 ).…”

Section: Methodsmentioning

confidence: 99%

Predictors of Gastrointestinal Transit Times in Colon Capsule Endoscopy

Moen

Vuik

Voortman

et al. 2022

Clin Transl Gastroenterol

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“…The SROC curve is illustrated in Figure 6. To investigate the clinical utility of the CAD models, Fagan's nomogram [50] was generated. Positive findings indicated that gastrointestinal ulcers or erosions were detected by the CAD models, while negative findings indicated that gastrointestinal ulcers or erosions were not detected by the CAD models.…”

Section: Dta Meta-analysis For the Performance Of Cad Modelsmentioning

confidence: 99%

Computer-Aided Diagnosis of Gastrointestinal Ulcer and Hemorrhage Using Wireless Capsule Endoscopy: Systematic Review and Diagnostic Test Accuracy Meta-analysis

Bang¹,

Lee²,

Baik³

2021

J Med Internet Res

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Background Interpretation of capsule endoscopy images or movies is operator-dependent and time-consuming. As a result, computer-aided diagnosis (CAD) has been applied to enhance the efficacy and accuracy of the review process. Two previous meta-analyses reported the diagnostic performance of CAD models for gastrointestinal ulcers or hemorrhage in capsule endoscopy. However, insufficient systematic reviews have been conducted, which cannot determine the real diagnostic validity of CAD models. Objective To evaluate the diagnostic test accuracy of CAD models for gastrointestinal ulcers or hemorrhage using wireless capsule endoscopic images. Methods We conducted core databases searching for studies based on CAD models for the diagnosis of ulcers or hemorrhage using capsule endoscopy and presenting data on diagnostic performance. Systematic review and diagnostic test accuracy meta-analysis were performed. Results Overall, 39 studies were included. The pooled area under the curve, sensitivity, specificity, and diagnostic odds ratio of CAD models for the diagnosis of ulcers (or erosions) were .97 (95% confidence interval, .95–.98), .93 (.89–.95), .92 (.89–.94), and 138 (79–243), respectively. The pooled area under the curve, sensitivity, specificity, and diagnostic odds ratio of CAD models for the diagnosis of hemorrhage (or angioectasia) were .99 (.98–.99), .96 (.94–0.97), .97 (.95–.99), and 888 (343–2303), respectively. Subgroup analyses showed robust results. Meta-regression showed that published year, number of training images, and target disease (ulcers vs erosions, hemorrhage vs angioectasia) was found to be the source of heterogeneity. No publication bias was detected. Conclusions CAD models showed high performance for the optical diagnosis of gastrointestinal ulcer and hemorrhage in wireless capsule endoscopy.

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“…Asymptomatic participants aged 50 to 75 years who underwent CCE were included 12 . People participating in the Rotterdam Study were eligible to participate in this study if they were aged 50 to 75 years and able to give informed consent.…”

Section: Methodsmentioning

confidence: 99%

Applicability of colon capsule endoscopy as pan-endoscopy: From bowel preparation, transit, and rating times to completion rate and patient acceptance

et al. 2021

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Background and study aims Colon capsule endoscopy (CCE) has the potential to explore the entire gastrointestinal tract. The aim of this study was to assess the applicability of CCE as pan-endoscopy. Patients and methods Healthy participants received CCE with bowel preparation (bisacodyl, polyethylene electrolyte glycol (PEG) + ascorbic acid) and booster regimen (metoclopramide, oral sulfate solution (OSS)). For each segment of the gastrointestinal tract, the following quality parameters were assessed: cleanliness, transit times, reading times, patient acceptance and safety of the procedure. When all gastrointestinal segments had cleansing score good or excellent, cleanliness of the whole gastrointestinal tract was assessed as good. Participants’ expected and perceived burden was assessed by questionnaires and participants were asked to grade the procedure (scale 0–10). All serious adverse events (SAEs) were documented. Results A total of 451 CCE procedures were analyzed. A good cleansing score was achieved in the stomach in 69.6%, in the SB in 99.1 % and in the colon in 76.6 %. Cleanliness of the whole gastrointestinal tract was good in 52.8 % of the participants. CCE median transit time of the whole gastrointestinal tract was 583 minutes IQR 303–659). The capsule reached the descending colon in 94.7 %. Median reading time per procedure was 70 minutes (IQR 57–83). Participants graded the procedure with a 7.8. There were no procedure-related SAEs. Conclusions CCE as pan-endoscopy has shown to be a safe procedure with good patient acceptance. When cleanliness of all gastrointestinal segments per patient, completion rate and reading time will be improved, CCE can be applied as a good non-invasive alternative to evaluate the gastrointestinal tract.

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Population-Based Prevalence of Gastrointestinal Abnormalities at Colon Capsule Endoscopy

Cited by 10 publications

References 24 publications

Predictors of Gastrointestinal Transit Times in Colon Capsule Endoscopy

Predictors of Gastrointestinal Transit Times in Colon Capsule Endoscopy

Computer-Aided Diagnosis of Gastrointestinal Ulcer and Hemorrhage Using Wireless Capsule Endoscopy: Systematic Review and Diagnostic Test Accuracy Meta-analysis

Applicability of colon capsule endoscopy as pan-endoscopy: From bowel preparation, transit, and rating times to completion rate and patient acceptance

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