Population-based, spatiotemporal modeling of social risk factors and mortality from schistosomiasis in Brazil between 1999 and 2018

Paz, Wandklebson Silva da; Duthie, Malcolm S.; Jesus, Amélia Ribeiro de; Araújo, Karina Conceição Gomes Machado de; Santos, Allan Dantas dos; Santos, Márcio Bezerra

doi:10.1016/j.actatropica.2021.105897

Cited by 21 publications

(20 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…More importantly, many of these cases occur in the elderly, and this considerably increases the risk of association with chronic non-infectious diseases as cardiovascular or digestive diseases, and neoplasms. Furthermore, prior studies conducted by our group showed an increase in the schistosomiasis mortality rate in age groups above 60 years [ 4 , 6 ]. Thereby, it suggests the chronicity of the disease, a higher risk of association with comorbidities, and death [ 3 , 7 ].…”

mentioning

confidence: 76%

“…Despite all the measures implemented by the PCE, as diagnosis and mass treatment of populations in endemic areas, schistosomiasis still has a high number of cases and deaths, and remains a serious public health concern in Brazil [ 6 , 11 , 20 ] . Herein, we conducted a pioneer, and population-based study, to assess the epidemiological profile and spatial and temporal patterns of deaths from schistosomiasis in Brazil, as basic and associated cause, in a period of 20 years.…”

Section: Discussionmentioning

confidence: 99%

“…Surprisingly, we observed higher schistosomiasis mortality rates among women. Usually, men are more exposed to S. mansoni infection, due to occupational activities (ie, fishing or farming), or leisure activities [ 6 , 21 , 22 ]. As a result, schistosomiasis death use to be higher in this group [ 4 , 6 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…Regardless being classified as the 12th largest economy in the world (Gross Domestic Product - GDP/2020 = R$7.4 trillion; dropped 4.1% last year), Brazil has important socioeconomic disparities [ 14 ]. Furthermore, there is a lack of a sewerage system and safe-drinking water access in many municipalities, which maintains the schistosomiasis transmission cycle [ 6 , 15 ].…”

Section: Methodsmentioning

confidence: 99%

“…In that regard, temporal and spatial analysis techniques are one of the most efficient methods, since they allow to monitor the impacts of the disease over time and in space [ 9 , 11 ]. Several studies have used spatial and spatiotemporal analysis tools to comprehend the dynamics of schistosomiasis in Brazil [ 4 , 6 , 12 ]. Nevertheless, there are no studies investigating the associated causes of death from the disease at the national level.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Basic and associated causes of schistosomiasis-related mortality in Brazil: A population-based study and a 20-year time series of a disease still neglected

et al. 2021

Self Cite

View full text Add to dashboard Cite

Background Schistosomiasis is a persistent public health problem in Brazil. Regardless advances in diagnosis and mass treatment, schistosomiasis has a severe impact on morbimortality in the country and remains a neglected tropical disease. Herein, we assessed the basic and associated causes of schistosomiasis-related deaths and the temporal and spatial patterns of mortality from the disease in Brazil between 1999 and 2018. Methods We conducted an ecological and time series study. The segmented log-linear regression model was applied to assess time trends, considering all deaths recorded in the category B65/ICD-10. Additionally, we elaborated maps of mortality rates from schistosomiasis in Brazil. Results A total of 4168 schistosomiasis-related deaths were recorded in Brazil in this period, as an associated cause. Time trend analysis revealed an increase in the average age of deaths from schistosomiasis (annual percentage change (APC) = 0.84), and stable trend in Brazil (APC = 0.31). Concerning schistosomiasis-related deaths, we observed disorders related to the digestive system, liver diseases, septicemias, and chronic diseases. Surprisingly, there were deaths caused by non-endemic Schistosoma species in Brazil. Also, municipalities from non-endemic areas in Brazil presented schistosomiasis-related deaths. Conclusion Altogether, our analyses demonstrated that schistosomiasis remains a significant cause of death in Brazil, and it is increasing in some areas, especially in the Northeast region. Additionally, women and the elderly showed a stable time trend of deaths. Thereby, it urgently requires improvements in the control programs strategies, in the sense of an effective reduction in cases and deaths from the disease in Brazil.

show abstract

mentioning

confidence: 76%