Population data for 21 autosomal short tandem repeat markers in the Arabic population of the United Arab Emirates

Jones, Rebecca J.; Tayyare, Wafa Al; Tay, G.K.; Alsafar, Habiba; Goodwin, William

doi:10.1016/j.fsigen.2017.02.015

Cited by 8 publications

(14 citation statements)

References 15 publications

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“…We have compared Bahraini population data to the nearest available populations using the accessible loci. It is shown that the Bahraini population shares similar results with the study conducted of Saudi Arabia and UAE populations using the GlobalFiler STR loci [19, 22] . As the above-mentioned populations share the most informative and polymorphic locus is SE33 and the least informative locus is TPOX.…”

Section: Discussionsupporting

confidence: 73%

“…To measure the diversity between Bahraini population and populations previously reported, phylogenetic tree and MDS were conducted between Qatari population [17] , Kuwaiti population [18] , Iraqi populations [18] , Iranian populations [18] , Egyptian population [18] , Bengali population [18] , Sri Lankan population [18] , Indian population [18] , Emirati population [19] and Saudi population [18] based on fixation index FST and Nei’s genetic distances respectively. The comparison with published data showed that the populations in this study had similar pairwise FST values with those populations that are geographically most.…”

Section: Resultsmentioning

confidence: 99%

“…Qatari population [17], Kuwaiti population [18], Iraqi populations [18], Iranian populations [18], Egyptian population [18], Bengali population [18], Sri Lankan population [18], Indian population [18], Emirati population [19] and Saudi population [18]. The tree was constructed with allele frequency data of fifteen STR loci (D8S1179, D21S11, D7S820, CSF1PO, D19S433, vWA, TPOX, D18S51, D5S818, FGA, D3S1358, TH01, D13S317, D16S539 and D2S1338) for all populations.…”

Section: Resultsmentioning

confidence: 99%

“…As the above-mentioned populations share the most informative and polymorphic locus is SE33 and the least informative locus is TPOX. The least polymorphic was locus D16S539 for UAE population [19] whereas THO1 for both Bahraini and Saudi Arabian populations [22]. Allele 8 in locus TPOX scored the highest frequency for Bahraini, Kuwaiti, Saudi Arabian, Iraqi, Egyptian and Iranian populations [18, 22] whereas the highest frequency for Indian and Bangladeshi populations is allele 12 in CSF1PO [18].…”

Section: Discussionmentioning

confidence: 99%

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Population genetic data of the 21 autosomal STRs included in GlobalFiler kit of a population sample from the Kingdom of Bahrain

et al. 2019

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Bahrain’s population consists mainly of Arabs, Baharna and Persians leading Bahrain to become ethnically diverse. The exploration of the ethnic origin and genetic structure within the Bahraini population is fundamental mainly in the field of population genetics and forensic science. The purpose of the study was to investigate and conduct genetic studies in the population of Bahrain to assist in the interpretation of DNA-based forensic evidence and in the construction of appropriate databases. 24 short-tandem repeats in the GlobalFiler PCR Amplification kit including 21 autosomal STR loci and three gender determination loci were amplified to characterize different genetic and forensic population parameters in a cohort of 543 Bahraini unrelated healthy men. Samples were collected during the year 2017. The genotyping of the 21 autosomal STRs showed all of the loci were in Hardy-Weinberg Equilibrium (HWE) after applying Bonferroni’s correction. We also found out no significant deviations from LD between pairwise STR loci in Bahraini population except when plotting for D3S1358-CSF1PO, CSF1PO-SE33, D19S433-D12S391, FGA-D2S1338, FGA-SE33, FGA-D7S820 and D7S820-SE33. The SE33 locus was the most polymorphic for the studied population and THO1 locus was the less polymorphic. The Allele 8 in TPOX scored the highest allele frequency of 0.496. The SE33 locus showed the highest power of discrimination (PD) in Bahraini population, whereas TPOX showed the lowest PD value. The 21 autosomal STRs showed a value of combined match probability (CMP) equal to 4.5633 E-27 , and a combined power of discrimination (CPD) of 99.99999999%. Off-ladders and tri-allelic variants were observed in various samples at D12S391, SE33 and D22S1045 loci. Additionally, pairwise genetic distances based on FST were calculated between Bahraini population and other populations extracted from the literature. Genetic distances were represented in a non-metric MDS plot and clustering of populations according to their geographic locations was detected. Phylogenetic tree was constructed to investigate the genetic relatedness between Bahraini population and the neighboring populations. Our study indicated that the twenty-one autosomal STRs are highly polymorphic in the Bahraini population and can be used as a powerful tool in forensics and population genetic analyses including paternity testing and familial DNA searching.

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Section: Discussionsupporting

confidence: 73%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Population genetic data of the 21 autosomal STRs included in GlobalFiler kit of a population sample from the Kingdom of Bahrain

et al. 2019

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“…Whilst the observed allele frequency variation between regions will have limited influence on interpretation issues, the high level of consanguinity and presence of null alleles should be taken into account. Comparative data sources and population abbreviations are as follows: BAH -Bahrain [20], EGY1, EGY2 -Egypt, respectively [5,21]; IRN1, IRN2 -Iran, respectively [5,22]; IRQ1, IRQ2 -Iraq, respectively [5,23]; JOR -Jordan [24]; KUW -Kuwait [5]; OMN -Oman [4]; QAT -Qatar [25]; SA1, SA2, SA3, SA4 -Saudi Arabia, respectively [2-5]; UAE1, UAE2 -United Arab Emirates, respectively [26,27]; YEM -Yemen [4].…”

Section: Resultsmentioning

confidence: 99%

Analysis of 21 autosomal STRs in Saudi Arabia reveals population structure and the influence of consanguinity

Khubrani

Wetton

Jobling

2019

Forensic Science International: Genetics

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Variation in the 21 autosomal STRs detected by the GlobalFiler multiplex was investigated in a sample of 523 indigenous male Arabs from five geographic regions of Saudi Arabia. Although allele frequencies for the entire dataset were found to be broadly similar to those determined in previous studies of Saudi citizens, significant differences were found among regions. Heterozygote deficiency was observed at nearly all loci in all regions, probably as a consequence of high levels of consanguineous marriage; in the case of D2S1338, which showed the largest deviation from Hardy-Weinberg equilibrium, the presence of a null allele also played a part. Genetic distances were greatest between the Northern and Southern regions, whilst the West, Central and East appeared most similar to each other, and to previously published surveys. This contrasts with previously described variation among paternal lineages in the same sample-set: Y-chromosome variation was limited within the North/Central/South core compared with the more diverse East and West. Differences between autosomal and Y-chromosomal patterns probably reflect genetic drift on the Y chromosome, exacerbated by prevalent patrilineal descent groups in different regions.

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Population genetic data for 21 autosomal STR loci for the Saudi Arabian population using the GlobalFiler ® PCR amplification kit

Alsafiah

Goodwin

Hadi

et al. 2017

Forensic Science International: Genetics

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Population data for 21 autosomal short tandem repeat markers in the Arabic population of the United Arab Emirates

Cited by 8 publications

References 15 publications

Population genetic data of the 21 autosomal STRs included in GlobalFiler kit of a population sample from the Kingdom of Bahrain

Population genetic data of the 21 autosomal STRs included in GlobalFiler kit of a population sample from the Kingdom of Bahrain

Analysis of 21 autosomal STRs in Saudi Arabia reveals population structure and the influence of consanguinity

Population genetic data for 21 autosomal STR loci for the Saudi Arabian population using the GlobalFiler ® PCR amplification kit

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