In order to trace the research history of diseases and pests in rubber tree and explore the potential for their natural control, a bibliometric analysis was conducted based on relevant documents retrieved from the Clarivate Analytics Web of Science (WoS) core collection SCI-E database. VOSviewer software was utilized to analyze the research distribution, scientific collaboration, knowledge structure, and research frontiers. The results show that annual publications on the diseases and pests of rubber tree have increased rapidly after 2005 after a long period of emergence and fluctuation. A total of 624 relevant publications from 51 countries/regions were identified. China was the most productive country with 152 documents, most of which were related to Colletotrichum leaf disease, powdery mildew, and other emerging diseases of rubber tree. France and Brazil produced rich research to tackle South American leaf blight, and have established a close collaborative relationship. Based on the analysis of themes and trend topics, pathogenicity mechanisms of fungal pathogens and plant defense mechanisms are currently hot topics. By further looking into the research, the defense-related genes of rubber tree and antagonistic mechanisms behind candidate biocontrol agents reveal great potential in developing natural control strategies. This study provides a useful reference about the progress and evolution of research into diseases and pests in rubber tree.