Population Ecology of Hantavirus Rodent Hosts in Southern Brazil

Teixeira, Bernardo Rodrigues; Loureiro, Nathalie; Strecht, Liana; Gentile, Rosana; Oliveira, Renata Carvalho de; Guterres, Alexandro; Fernandes, Jorlan; Mattos, Luciana H. B. V.; Raboni, Sônia Mara; Rubio, Gisélia Burigo Guimarães; Bonvicino, Cibele Rodrigues; Santos, Claudia Nunes Duarte dos; Lemos, Elba Regina Sampaio de; D’Andrea, Paulo Sérgio

doi:10.4269/ajtmh.13-0465

Cited by 22 publications

(20 citation statements)

References 73 publications

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“…18 Furthermore, the occurrence of JUQV-like infection in two different genera of hosts suggests a potential adaptation of this genotype to genetically distinct rodent species, as previously observed in the central and southern regions of Brazil, where distinct rodent species, A. montensis, Akodon paranaensis, Oligoryzomys mattogrossae (fornesi), Oligoryzomys Judex, and Thaptomys nigrita have been identified as being naturally infected with JUQV. [19][20][21][22] In this study, the cursor grass mouse was the most abundant species identified and has adapted to exist in primary and secondary forests, especially in the transition area between Atlantic Forest and Cerrado areas in southeastern Brazil. It is a generalist species that occurs near human habitation, as does the black-footed pygmy rice rat (O. nigripes).…”

Section: Resultsmentioning

confidence: 89%

A Fatal Hantavirus Pulmonary Syndrome Misdiagnosed as Dengue: An Investigation into the First Reported Case in Rio de Janeiro State, Brazil

Oliveira

Guterres

Teixeira

et al. 2017

The American Society of Tropical Medicine and Hygiene

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We report the results of an investigation into a fatal case of hantavirus pulmonary syndrome (HPS) in Rio de Janeiro State, Brazil, where the disease had not been reported previous to 2015. Following the notification of an HPS case, serum samples were collected from the household members and work contacts of the HPS patient and tested for antibody to hantaviruses. Seroprevalence of 22% (10/45) was indicated for hantavirus out of 45 human samples tested. Blood and tissue samples were collected from 72 rodents during fieldwork to evaluate the prevalence of hantavirus infection, by using enzyme-linked immunosorbent assay IgG, and to characterize the rodent hantavirus reservoir(s), by reverse transcription polymerase chain reaction and sequencing. Antibody prevalence was 6.9%. The circulation of a single genotype, the Juquitiba hantavirus, carried by two rodent species, black-footed pigmy rice rat () and cursor grass mouse (), was shown by analysis of the nucleotide sequences of the S segment. Juquitiba hantavirus circulates in rodents of various species, but mainly in the black-footed pigmy rice rat. HPS is a newly recognized clinical entity in Rio de Janeiro State and should be considered in patients with febrile illness and acute respiratory distress.

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Section: Resultsmentioning

confidence: 89%

A Fatal Hantavirus Pulmonary Syndrome Misdiagnosed as Dengue: An Investigation into the First Reported Case in Rio de Janeiro State, Brazil

Oliveira

Guterres

Teixeira

et al. 2017

The American Society of Tropical Medicine and Hygiene

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“…Temperature can affect vegetation growth [29] and the survival rate of rodents [85], with mild temperatures (10–25°C) being most favorable for rodent breeding [86]. Additionally, reservoir rodents normally exhibit a peak in hantavirus infection during warmer months [87; 88; 89; 90], probably because high temperature leads to greater aerosolization of the virus and higher rates of inhalation by both humans and rodents [12; 13]. At present there are no data available on the effects of temperature on HPS virus survival, but laboratory experiments found that Puumala viruses (aetiological agent of Hantavirus infection in Western Europe) can remain infectious for longer (i.e.12 to 15 days) at room temperature (23°C; 73°F) [91], losing their viability if kept at 37°C [91].…”

Section: Discussionmentioning

confidence: 99%

Landscape, Environmental and Social Predictors of Hantavirus Risk in São Paulo, Brazil

et al. 2016

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Hantavirus Pulmonary Syndrome (HPS) is a disease caused by Hantavirus, which are negative-sense RNA viruses in the family Bunyaviridae that are highly virulent to humans. Numerous factors modify risk of Hantavirus transmission and consequent HPS risk. Human-driven landscape change can foster transmission risk by increasing numbers of habitat generalist rodent species that serve as the principal reservoir host. Climate can also affect rodent population dynamics and Hantavirus survival, and a number of social factors can influence probability of HPS transmission to humans. Evaluating contributions of these factors to HPS risk may enable predictions of future outbreaks, and is critical to development of effective public health strategies. Here we rely on a Bayesian model to quantify associations between annual HPS incidence across the state of São Paulo, Brazil (1993–2012) and climate variables (annual precipitation, annual mean temperature), landscape structure metrics (proportion of native habitat cover, number of forest fragments, proportion of area planted with sugarcane), and social factors (number of men older than 14 years and Human Development Index). We built separate models for the main two biomes of the state (cerrado and Atlantic forest). In both biomes Hantavirus risk increased with proportion of land cultivated for sugarcane and HDI, but proportion of forest cover, annual mean temperature, and population at risk also showed positive relationships in the Atlantic forest. Our analysis provides the first evidence that social, landscape, and climate factors are associated with HPS incidence in the Neotropics. Our risk map can be used to support the adoption of preventive measures and optimize the allocation of resources to avoid disease propagation, especially in municipalities that show medium to high HPS risk (> 5% of risk), and aimed at sugarcane workers, minimizing the risk of future HPS outbreaks.

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“…The rodents were euthanized and necropsied, and their bionomic data were recorded (i.e., age, gender, reproductive activity, body mass and external measurements). Host ages were based on body mass (grams), dividing individuals into two classes: juvenile (< 28 g for A. montensis and < 18 g for O. nigripes) and adult (≥ 28 g for A. montensis and ≥ 18 g for O. nigripes) (adapted from Teixeira et al 2014). Rodents were identified by external and cranial morphology and by cytogenetics analysis (diploid number) (Bonvicino et al 2008).…”

Section: Collection and Examination Of Rodentsmentioning

confidence: 99%

Helminth Community Structure of Two Sigmodontine Rodents in Serra Dos Órgãos National Park, State of Rio De Janeiro, Brazil

et al. 2019

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The fauna and community structure of the helminths of two sympatric sigmodontine rodent hosts, Akodon montensis (Thomas, 1913) and Oligoryzomys nigripes (Olfers, 1818) (Rodentia, Cricetidae) were studied in two areas of an Atlantic Forest reserve, the Serra dos Órgãos National Park in Petrópolis and Teresópolis municipalities, state of Rio de Janeiro, Brazil. During the study, 127 rodents were collected, among which 63 were parasitized (approximately 50%). The helminths recovered from A. montensis were the nematodes Protospirura numidica criceticola, Stilestrongylus aculeata, Stilestrongylus eta, Stilestrongylus lanfrediae and Trichofreitasia lenti; the trematode Canaania obesa and the cestode Rodentolepis akodontis. Oligoryzomys nigripes was infected by Avellaria sp., Guerrerostrongylus zetta, T. lenti and S. lanfrediae. Complete host specificity was observed in all helminth species only in Petrópolis; although T. lenti and S. lanfrediae were shared between host species in Teresópolis. Stilestrongylus aculeata, S. eta and S. lanfrediae had the greatest abundance, i.e. considering all hosts, and intensity, i.e. considering only infected hosts, in the study. Stilestrongylus lanfrediae and G. zetta were the most prevalent species. Guerrerostrongylus zetta and S. lanfrediae had higher abundance and prevalence in adult hosts. The latter species also had higher abundance and prevalence in male hosts. Stilestrongylus aculeata and S. eta had higher prevalence in young female hosts, and T. lenti, higher abundance in males and higher prevalence in adult females of A. montensis. Only the helminth community of O. nigripes in Teresópolis followed a nested pattern of species distribution. All the other helminth communities in A. montensis and O. nigripes had random patterns of species distribution. The results suggest the existence of intrinsic characteristics between hosts and parasites as well as different patterns of associations in those interactions with the environment.

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Population Ecology of Hantavirus Rodent Hosts in Southern Brazil

Cited by 22 publications

References 73 publications

A Fatal Hantavirus Pulmonary Syndrome Misdiagnosed as Dengue: An Investigation into the First Reported Case in Rio de Janeiro State, Brazil

A Fatal Hantavirus Pulmonary Syndrome Misdiagnosed as Dengue: An Investigation into the First Reported Case in Rio de Janeiro State, Brazil

Landscape, Environmental and Social Predictors of Hantavirus Risk in São Paulo, Brazil

Helminth Community Structure of Two Sigmodontine Rodents in Serra Dos Órgãos National Park, State of Rio De Janeiro, Brazil

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