Population genetic analyses of susceptibility to increased body weight

Nikolić, Dejan; Cvjetićanin, Suzana; Petronić, Ivana; Milincic, Z.; Brdar, Radivoj; Karan, Radmila; Konstantinović, Ljubica; Dragin, Aleksandra; Cutovic, Milisav

doi:10.5114/aoms.2012.32405

Cited by 7 publications

(9 citation statements)

References 12 publications

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“…Despite the numerous population genetic studies previously conducted [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 20 , 21 , 22 ], establishing expected phenotype variations in humans is still a challenging task. Our findings are in line with such statement, since we have demonstrated the presence of differences in such variations between evaluated groups.…”

Section: Discussionmentioning

confidence: 99%

“…The HRC-test has been developed to establish the proportion of homozygously-recessive clearly-expressed characteristics in every individual as markers of chromosomal homozygosities, implicating the degree of genetic homozygosity in humans [ 8 , 16 , 20 , 21 ]. It is reliable method for estimating the individual homozygosity and is performed by direct observation of defined phenotype traits [ 9 , 10 , 16 , 20 , 21 , 22 ]. To secure the same objectivity and equal criteria for determination of HRCs, one person performed the testing on studied population.…”

Section: Methodsmentioning

confidence: 99%

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Genetic and Environmental Dispositions for Cardiovascular Variability: A Pilot Study

Karan

Cvjetićanin

Kovačević-Kostić

et al. 2018

JCM

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Background: The aim of our study was to evaluate the degree of genetic homozygosity in the group of patients with coronary artery disease (CAD), as well as to evaluate morphogenetic variability in CAD patients regarding the presence of investigated risk factors (RF) compared to a control sample of individuals. Additionally, we aimed to evaluate the distribution of ABO blood type frequencies between tested samples of individuals. Methods: This study analyzed individual phenotype and morphogenetic variability of 17 homozygously-recessive characteristics (HRC), by using HRC test in a sample of 148 individuals in CAD patients group and 156 individuals in the control group. The following RF were analyzed: hypertension, diabetes mellitus, hyperlipidemia, and smoking. Results: The mean value of HRC in CAD patients is significantly higher, while variability decreases compared to the control sample (CAD patients: 4.24 ± 1.59, control sample: 3.75 ± 1.69; VCAD-patients = 37.50%, VC = 45.07%). There is a significant difference in individual variations of 17 HRC between control sample and CAD patients (χ2 = 169.144; p < 0.01), which points out to different variability for tested genes. Mean values of HRC significantly differed in CAD patients in regard to the number of RF present. A blood type (OR = 1.75) is significant predictor for CAD, while O blood type (OR = 0.43) was significantly associated with controls. Conclusion: There is a higher degree of recessive homozygosity in CAD patients versus individuals in the control sample, and the presence of significant variations in the degree of recessive homozygosity as the number of tested RF increases.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Genetic and Environmental Dispositions for Cardiovascular Variability: A Pilot Study

Karan

Cvjetićanin

Kovačević-Kostić

et al. 2018

JCM

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“…Obesity has a constantly growing prevalence worldwide, and it represents one of the most important health risks of our time [ 40 – 42 ], so it is recommended that studies that deal with obesity effects on different aspects of health must be continued.…”

Section: Discussionmentioning

confidence: 99%

Effect of feeding a high-fat diet independently of caloric intake on reproductive function in diet-induced obese female rats

Hussain¹,

Abogresha²,

Hassan³

et al. 2016

aoms

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IntroductionGlobally, the prevalence of overweight and obesity is increasing, predisposing females to health hazards including compromised reproductive capacity. Our objective was to investigate the effect of ad libitum, isocalorically and hypocalorically restricted high-fat diet (HFD) feeding on reproductive function in diet-induced obese female rats.Material and methodsTwenty female albino Sprague Dawley rats were used; 5 rats were kept on a standard pellet animal diet to serve as a control group (A) and 15 rats were fed a HFD for 9 weeks to induce obesity. The HFD fed animals were equally divided into three groups: an ad libitum HFD group (B), an isocalorically restricted HFD group (C), and a hypocalorically restricted HFD group (D). Estrous cyclicity, hormonal levels, ovarian histopathology and caspase-3 immunoreactivity were evaluated.ResultsThe HFD-fed rats in groups B, C and D had significant irregularity in estrous cyclicity Vs group A (p = 0.001, 0.003 and 0.034 respectively). Groups C and D had significant reduction in serum progesterone level (p = 0.006 and 0.018 Vs A). Isocaloric restriction of HFD feeding significantly increased serum LH. Groups B and C had a significant increase in caspase-3 expression in the ovary (p < 0.001).ConclusionsAd libitum HFD interfered with the normal estrous cycle and enhanced apoptosis of luteal cells in obese female rats. The HFD restriction interfered with the normal estrous cycle and caused functional insufficiency of the corpus luteum in obese female rats. These results suggest that HFD feeding determinately affects female reproductive function independently of caloric intake.

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“…During the thirty years of developing the homozygous recessive characteristics (HRC) test, the authors of the Belgrade population-genetic school selected 15 to 20 as the most reliable characteristics according to the type of inheritance and variability [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ]. By establishing the extremely expressed recessive phenotypes, they actually gained insight into the status of these gene loci and the general homozygosity of individuals and groups.…”

Section: Introductionmentioning

confidence: 99%

“…These authors studied the distribution and frequency of a series of highly expressed recessive morphophysiological traits in order to estimate individual and group differences (i.e., comparison between ill and healthy individuals, pupils from special and regular schools and carriers of different blood types). Furthermore, previous population genetics studies showed that the number of tested traits was adequate for comparisons of different subpopulation groups [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Morphogenetic Variability and Hypertension in Ischemic Stroke Patients—Preliminary Study

Savić

Cvjetićanin

Lazović

et al. 2018

JCM

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In this study, we evaluated and compared the morphogenetic variability and the degree of recessive homozygosity in patients with manifested ischemic stroke compared to healthy controls. We have evaluated 120 patients with manifested ischemic stroke, of which 64 did not have hypertension and 56 have hypertension. For comparison, we additionally tested 194 healthy individuals without manifested ischemic stroke (controls). For the estimation of the degree of recessive homozygosity, we have performed the homozygously recessive characteristics (HRC) test and tested 19 HRCs. There was a significant difference in the individual variations of 19 HRCs between the controls and patients with manifested ischemic stroke (∑χ2 = 60.162, p < 0.01). The mean values of the tested HRCs significantly differed between the controls and group with manifested ischemic stroke (Controls − 5.71 ± 1.61, Ischemic stroke group − 6.25 ± 1.54, p = 0.012). For the tested individuals with hypertension, the mean values of HRCs did not significantly differ between the controls and those that had manifested ischemic stroke (Controls − 5.28 ± 1.75, Ischemic stroke group − 5.64 ± 1.48, p = 0.435). We found a significant difference in the frequencies of HRCs between those with and without hypertension for controls (p < 0.003) and for those with manifested ischemic stroke (p < 0.001). There are increased degrees of recessive homozygosity along with decreased variability in patients with manifested ischemic stroke compared to controls.

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Population genetic analyses of susceptibility to increased body weight

Cited by 7 publications

References 12 publications

Genetic and Environmental Dispositions for Cardiovascular Variability: A Pilot Study

Genetic and Environmental Dispositions for Cardiovascular Variability: A Pilot Study

Effect of feeding a high-fat diet independently of caloric intake on reproductive function in diet-induced obese female rats

Morphogenetic Variability and Hypertension in Ischemic Stroke Patients—Preliminary Study

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