Population-Level Configurations of Gut Mycobiome Across 6 Ethnicities in Urban and Rural China

Sun, Yuhao; Zuo, Tao; Cheung, Chun Pan; Gu, Wen; Wan, Yating; Zhang, Fen; Chen, Nan; Zhan, Hui; Yeoh, Yun Kit; Niu, Junkun; Du, Yuwen; Zhang, Fengrui; Wen, Yunling; Yu, Jun; Sung, Joseph J.Y.; Chan, Paul K.S.; Chan, Francis K.L.; Wang, Kunhua; Ng, Siew C.; Miao, Yi

doi:10.1053/j.gastro.2020.09.014

Cited by 84 publications

(66 citation statements)

References 46 publications

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“…Another large study (942 human adults) found a positive correlation between fungal and bacterial richness in the gut, with is suggestive of mutualism between both kingdoms, yet failed to uncover correlations between fungi and bacteria at the species level. 25 Taken together, the studies described in this section, while short of providing mechanistic details, do indicate that fungi and bacteria impact on the proliferation of each other in the mammalian gut.…”

Section: Interdependencies Between Bacteria and Fungi In The Mammalian Gutmentioning

confidence: 77%

The interplay between gut bacteria and the yeast Candida albicans

Pérez

2021

Gut Microbes

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The fungus Candida albicans is a ubiquitous member of the human gut microbiota. Hundreds or thousands of bacterial taxa reside together with this fungus in the intestine, creating a milieu with myriad opportunities for inter-kingdom interactions. Indeed, recent studies examining the broader composition – that is, monitoring not only bacteria but also the often neglected fungal component – of the gut microbiota hint that there are significant interdependencies between fungi and bacteria. Gut bacteria closely associate with C. albicans cells in the colon, break down and feed on complex sugars decorating the fungal cell wall, and shape the intestinal microhabitats occupied by the fungus. Peptidoglycan subunits released by bacteria upon antibiotic treatment can promote C. albicans dissemination from the intestine, seeding bloodstream infections that often become life-threatening. Elucidating the principles that govern the fungus-bacteria interplay may open the door to novel approaches to prevent C. albicans infections originating in the gut.

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Section: Interdependencies Between Bacteria and Fungi In The Mammalian Gutmentioning

confidence: 77%

The interplay between gut bacteria and the yeast Candida albicans

Pérez

2021

Gut Microbes

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“…Currently, the most suitable sample for detecting SARS-CoV-2 is the human nasal swab; however, there are already studies that have shown digestive symptoms (e.g. diarrhea and vomiting) 10 , 11 and other less frequent symptoms (e.g. conjunctivitis) in patients who tested positive for SARS-CoV-2 12 – 14 .…”

Section: Discussionmentioning

confidence: 99%

Design and in silico validation of polymerase chain reaction primers to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Davi

Jerônimo

Lima

et al. 2021

Sci Rep

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Accurate designing of polymerase chain reaction (PCR) primers targeting conserved segments in viral genomes is desirable for preventing false-negative results and decreasing the need for standardization across different PCR protocols. In this work, we designed and described a set of primers and probes targeting conserved regions identified from a multiple sequence alignment of 2341 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) genomes from the Global Initiative on Sharing All Influenza Data (GISAID). We subsequently validated those primers and probes in 211,833 SARS-CoV-2 whole-genome sequences. We obtained nine systems (forward primer + reverse primer + probe) that potentially anneal to highly conserved regions of the virus genome from these analyses. In silico predictions also demonstrated that those primers do not bind to nonspecific targets for human, bacterial, fungal, apicomplexan, and other Betacoronaviruses and less pathogenic sub-strains of coronavirus. The availability of these primer and probe sequences will make it possible to validate more efficient protocols for identifying SARS-CoV-2.

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“…The level of C. albicans in the stool has correlated with the cleaning of teeth ( 18 ). The study of Sun et al ( 46 ) also studied the fecal mycobiome using metagenomic sequencing to associate fungal communities in the rural and urban populations of China. In brief, S. cerevisiae was more abundant while Candida dubliniensis was low in abundance in urban compared with rural population suggesting that distinct food habits in the shaping of gut mycobiota composition.…”

Section: Introductionmentioning

confidence: 99%

Food Habit Associated Mycobiota Composition and Their Impact on Human Health

Shankar

2021

Front. Nutr.

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Mycobiota is not only associated with healthy homeostasis in the human gut but also helps to adapt to the environment. Food habits, alcohol consumption, intake of probiotics, and contaminated food with a mycotoxin, often lead to the alteration in the mycobiota composition. Impaired immunity of the host may affect fungal symbiosis leading to mycosis. The human gut adapts to the commensalism fungi belonging to the phylum Ascomycota and Basidiomycota. Diet habits such as plant-or animal-based, phytoestrogens enriched plant products, fat-rich diets also influence the colonization of certain fungal species in the mammalian gut. Food habits or mycotoxin-contaminated food or fungal peptides have an impact on bacterial-fungal interaction and human health. The mycobiota population such as Fusarium, Humicola, Aspergillus, and Candida are altered due to alcohol intake in alcoholic liver disease. The role of associated gut mycobiota due to irregular bowel habits or lifestyle change has been observed in inflammatory bowel disease. In this review, it has been observed that Saccharomyces, Aspergillus, Fusarium, Cladosporium, Candida, and Malassezia were the common genus in the human mycobiota. Therefore, this study focused on how diet habits and alcohol intake, among others., influence mycobiota composition that may affect the human immune system or overall health.

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Population-Level Configurations of Gut Mycobiome Across 6 Ethnicities in Urban and Rural China

Cited by 84 publications

References 46 publications

The interplay between gut bacteria and the yeast Candida albicans

The interplay between gut bacteria and the yeast Candida albicans

Design and in silico validation of polymerase chain reaction primers to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Food Habit Associated Mycobiota Composition and Their Impact on Human Health

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