Population pharmacokinetics of 25-hydroxy vitamin D in children with asthma

Abstract

These results could be of help for individualization of vitamin D supplementation doses in this vulnerable population. .

Population pharmacokinetics and dose optimisation of colecalciferol in paediatric patients with chronic kidney disease

“…In a model‐based meta‐analysis of PK data in healthy or osteoporotic adult subjects, a model with a central and a peripheral compartment (2‐compartment model) was found to best fit the data 18 . In contrast, 1‐compartment models have been described in studies with sparse data 19–22 . Thus, both 1‐ and 2‐compartment models were tested using both untransformed and log‐transformed data.…”

“… 18 In contrast, 1‐compartment models have been described in studies with sparse data. 19 , 20 , 21 , 22 Thus, both 1‐ and 2‐compartment models were tested using both untransformed and log‐transformed data. Body weight as the continuous covariate for apparent clearance and apparent volume parameters with allometric scaling was included a priori.…”