The significant role of dietary intake of vitamin D in non-menopausal women health

Milovanović, Jasmina R.; Milovanovic, Olivera; Lucic, Aleksandra Tomic; Djoković, Jelena M.; Cvetković, Tatjana; Zivanovic, Svetlana; Barjaktarevic, Ana; Pantović, Suzana; Radovanović, Milan; Dimitrijević, Aleksandra; Janković, Slobodan M.; Radovanović, Radmila Veličković

doi:10.1080/03630242.2021.1917480

Cited by 1 publication

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“…Its receptor also plays a significant role in regulating steroid hormones in the female reproductive system [ 15 ]. Studies suggest a sufficient serum level of the vitamin D has positive effects on ovary function and regulation of menstrual cycles [ 24 ]. Prostaglandin metabolites increase vasoconstriction and myometrial contractions causing uterine ischemia in the uterus and pain [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

The effect of vitamin D on the severity of dysmenorrhea and menstrual blood loss: a randomized clinical trial

et al. 2023

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Background Primary dysmenorrhea is considered as one of the women’s main problems during reproductive age. The present study aimed to investigate the effect of vitamin D on the severity of dysmenorrhea and menstrual blood loss. Methods This double-blind, randomized, placebo-controlled trial, was performed on 84 single female college students between 18 and 25 years old who living in dormitories. Students with primary dysmenorrhea and vitamin D deficiency were divided into experimental (n = 42) and control (n = 42) groups. Five days before the putative beginning of their next menstrual cycle, the experimental group received 300,000 IU vitamin D (50,000 IU, two tablets every 8 h), and the control group received a placebo (oral paraffin). The effects of the supplement on the severity of dysmenorrhea and menstrual blood loss were evaluated one cycle before and during two successive cycles. Using the visual analog scale (VAS), verbal multidimensional scoring system (VMS), and pictorial blood assessment chart (PBLAC) questionnaires. Fisher’s exact, Chi-square, independent sample t-test and repeated measurements were used. Results In total, 78 of the 84 students completed the study (39 students per group). The intervention resulted in a significant reduction in the mean scores of both the VAS and VMS in the experimental group, in the first and second menstrual cycles (p < 0.001, p < 0.001, respectively), but not in the means score of PBLAC. Mefenamic acid consumption at the first and second menstruation period, in the experimental group was lower than the control group (p = 0.009, p < 0.001, respectively). Conclusions The results indicate that vitamin D supplementation could decrease the severity of primary dysmenorrhea and the need to consume pain-relief medications. Contrariwise vitamin D supplementation had no significant effect on menstrual blood loss. Trial registration This trial was registered in the Iranian Registry of Clinical Trials with code IRCT201305212324N on 18/1/2014. URL of registry: https://en.irct.ir/trial/1964.

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Section: Discussionmentioning

confidence: 99%