The effect of vitamin D on the severity of dysmenorrhea and menstrual blood loss: a randomized clinical trial

Amzajerdi, Azam; Keshavarz, Maryam; Ghorbali, Elham; Pezaro, Sally; Sarvi, Fatemeh

doi:10.1186/s12905-023-02284-5

Cited by 6 publications

(14 citation statements)

References 24 publications

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“…As the duration of the menstrual cycle ranged from 21 to 35 days, as one of the inclusion criteria, our analysis of the study duration time was divided into two groups: over or under 70 days (two cycles). Various dose intervals for each regimen were found, including once in the study period (2/9) [ 20 , 23 ], monthly (3/9) [ 9 , 16 , 17 ], weekly (3/9) [ 18 , 21 , 22 ], and daily (1/9) [ 19 ]. Using the Endocrine Society’s Definition of vit.…”

Section: Discussionmentioning

confidence: 99%

Effect of Vitamin D Supplementation on Primary Dysmenorrhea: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

et al. 2023

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Dysmenorrhea causes pain and inconvenience during menstruation. In addition to medication, natural compounds are widely used to relieve various types of pain. In this study, we aimed to assess the effects of vitamin D (vit. D) supplementation in relieving the symptoms of primary dysmenorrhea. A comprehensive systematic database search of randomized controlled trials (RCTs) was performed. Oral forms of vit. D supplementation were included and compared with a placebo or standard care. The degree of dysmenorrhea pain was measured with a visual analogue scale or numerical rating scale. Outcomes were compared using the standardized mean difference (SMD) and 95% confidence intervals (CIs) in a meta-analysis. RCTs were assessed using the Cochrane risk-of-bias v2 (RoB 2) tool. The meta-analysis included 8 randomized controlled trials involving 695 participants. The results of the quantitative analysis showed a significantly lower degree of pain in the vit. D versus placebo in those with dysmenorrhea (SMD: −1.404, 95% CI: −2.078 to −0.731). The results of subgroup analysis revealed that pain lessened when the average weekly dose of vit. D was over 50,000 IU, in which dysmenorrhea was relieved regardless of whether vit. D was administered for more or less than 70 days and in any dose interval. The results revealed that vit. D treatment substantially reduced the pain level in the primary dysmenorrhea population. We concluded that vit. D supplementation is an alternative treatment for relieving the pain symptoms of dysmenorrhea.

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Section: Discussionmentioning

confidence: 99%

Effect of Vitamin D Supplementation on Primary Dysmenorrhea: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

et al. 2023

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“…Similarly, Amzajerdi et al . [ 25 ] reported that high-dose Vitamin D supplementation (300,000 IU/day) significantly decreased the VAS and VMS scores for dysmenorrhea over two months. A systematic review reported significantly reduced dysmenorrhea after vitamin D and calcium supplementation [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…A secondary objective involved examining the correlation between vitamin D levels and dysmenorrhea severity using Pearson's correlation analysis. The VAS, a 10-point scale (0=no pain, 10=worst pain) [ 24 ], and the VMS, a 4-point scale (ranging from no pain to severe pain) [ 25 ], were employed to evaluate dysmenorrhea severity.…”

Section: Methodsmentioning

confidence: 99%

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The effect of vitamin D on adolescents’ primary dysmenorrhea

Samaha,

Donayeva,

Amanzholkyzy

et al. 2023

JMedLife

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Vitamin D receptor (VDR) expression in the female reproductive tract explains the regulatory role of vitamin D on inflammatory cytokine and prostaglandin (PGD) synthesis. This study aimed to evaluate the effect of vitamin D on adolescents’ primary dysmenorrhea and the relationship between Vit. D and adolescents’ primary dysmenorrhea. Eighty-five adolescents were included in the current study. After a detailed evaluation, pelvic sonography was performed for all participants to rule out any pelvic pathology. Blood samples were collected to measure thyroid stimulating hormone (TSH), prolactin, glycosylated hemoglobin (HbA1C), and 25-hydroxyvitamin D (25[OH]D). Participants were administered vitamin D (50,000 IU weekly for five months), and their dysmenorrhea symptoms were evaluated before and after this period using the Visual Analog Scale (VAS) and the Verbal Multidimensional Scoring (VMS). The mean VAS and VMS scores of dysmenorrhea statistically decreased from 8.7±0.91 and 2.65±0.93 to 4.8±0.75 and 0.80±0.75, respectively, after vitamin D intake (p=0.03 and 0.025, respectively). Significant negative associations between 25(OH)D and VAS (R = -0.886; p<0.00001) and VMS of dysmenorrhea (R = -0.885; p<0.00001) were detected in this study. Vit. D could be a useful therapeutic option to reduce the severity of primary dysmenorrhea and could limit the use of non-steroidal anti-inflammatory drugs.

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“…Vitamin D deficiency has been reported to induce or exacerbate dysmenorrhoea symptoms [14]. Notably, several randomised controlled trials (RCTs) have demonstrated that vitamin D supplementation reduces pain intensity in patients with dysmenorrhoea; thus, this may be an alternative treatment option for dysmenorrhoea [15][16][17][18][19][20][21][22]. However, other studies have reported limited effects [23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Supplementation for Patients with Dysmenorrhoea: A Meta-Analysis with Trial Sequential Analysis of Randomised Controlled Trials

Lin,

Huang,

Lin

et al. 2024

Nutrients

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Vitamin D reduces prostaglandin levels and inflammation, making it a promising treatment option for dysmenorrhoea. However, its effects on pain intensity in different types of dysmenorrhoea remain unclear. We examined whether vitamin D supplementation decreases pain intensity in patients with dysmenorrhoea. The Cochrane Library, Embase, Google Scholar, Medline, and Scopus databases were searched from inception to 30 December 2023. Randomised controlled trials (RCTs) evaluating vitamin D supplementation effects on such patients were included. The primary and secondary outcomes were measured by the changes in pain intensity and rescue analgesic use, respectively. Pooled mean differences and rate ratios were calculated using a random-effect model; trial sequential analysis (TSA) was also performed. Overall, 11 studies involving 687 participants were included. Vitamin D supplementation significantly decreased pain intensity in patients with dysmenorrhoea compared with controls (pooled mean difference, −1.64; 95% confidence interval, −2.27 to −1.00; p < 0.001; CoE, moderate; I2 statistic, 79.43%) and indicated substantial heterogeneity among the included studies. TSA revealed that the current RCTs provide sufficient information. In subgroup analyses, vitamin D supplement reduced primary dysmenorrhoea pain but not secondary dysmenorrhoea pain. In conclusion, although substantial heterogeneity persists, vitamin D supplementation decreased pain intensity in patients with dysmenorrhea, especially in those with primary dysmenorrhoea.

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The effect of vitamin D on the severity of dysmenorrhea and menstrual blood loss: a randomized clinical trial

Cited by 6 publications

References 24 publications

Effect of Vitamin D Supplementation on Primary Dysmenorrhea: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Effect of Vitamin D Supplementation on Primary Dysmenorrhea: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

The effect of vitamin D on adolescents’ primary dysmenorrhea

Vitamin D Supplementation for Patients with Dysmenorrhoea: A Meta-Analysis with Trial Sequential Analysis of Randomised Controlled Trials

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