Population pharmacokinetics of peginterferon α2a in patients with chronic hepatitis B

Bi, Jian; Li, Xingang; Liu, Jia; Chen, Dawei; Li, Shuo; Hou, Jun; Zhou, Yi; Zhu, Shanwei; Zhi-gang, Zhao; Qin, Enqiang; Wei, Zhenman

doi:10.1038/s41598-017-08205-5

Cited by 5 publications

(4 citation statements)

References 15 publications

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“…the population). 2 The characteristics of many patients (covariates), such as the state of the disease, demographics, concomitant medications, or the presence of renal or hepatic impairment, can all have an effect on drug pharmacokinetics. Therefore, it is essential to understand this variability to help guide safe and effective dosing regimens.…”

Section: Introductionmentioning

confidence: 99%

Impact of gender, albumin, and CYP2C19 polymorphisms on valproic acid in Chinese patients: a population pharmacokinetic model

Guo

Huo

et al. 2020

J Int Med Res

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Objective This prospective study aimed to establish the valproic acid (VPA) population pharmacokinetic model in Chinese patients and realise personalised medication on the basis of population pharmacokinetics. Methods The patients’ clinical information and VPA plasma concentrations were collected from The General Hospital of Taiyuan Iron & Steel (Group) Corporation (TISCO). Nonlinear mixed-effect modelling was used to build the population pharmacokinetic model. To characterise the pharmacokinetic data, a one-compartment pharmacokinetic model with first-order absorption and elimination was used. The first-order conditional estimation with η-ε interaction was applied throughout the model-developing procedure. The absorption rate constant (Ka) was fixed at 2.38 hour−1, and the impact of covariates on clearance and apparent volume of distribution were also explored. Medical records of 60 inpatients were reviewed prospectively and the objective function value (OFV) of the base model and final model were 851.813 and 817.622, respectively. Results Gender was identified as the covariate that had a significant impact on the volume of distribution, and albumin and CYP2C19 genotypes influenced clearance. Conclusion Bootstrap and VPC indicated that a reliable model had been developed that was based on the simulation results, and a simple-to-use dosage regimen table was created to guide clinicians for VPA drug dosing.

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Section: Introductionmentioning

confidence: 99%

Impact of gender, albumin, and CYP2C19 polymorphisms on valproic acid in Chinese patients: a population pharmacokinetic model

Guo

Huo

et al. 2020

J Int Med Res

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“…Low vancomycin concentration can lead to treatment failure, so it is necessary to study the correlation between BMI and the concentration of vancomycin. Indeed, there were studies already had shown that Vd was associated with BMI, and drug clearance (CL) had a positive correlation with CrCl [25,26]. Hence, we speculate that the effect of BMI on vancomycin 9 concentration may be achieved by affecting the Vd, while the effect of CrCl on vancomycin concentration was mainly achieved by affecting the drug CL.…”

Section: Discussionmentioning

confidence: 82%

The effect of body mass index and creatinine clearance on serum trough concentration of vancomycin in adult patients

Pan

Yao

et al. 2020

Preprint

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Background: The aim of this study was to evaluate the influence of patient body mass index (BMI) and estimated creatinine clearance (CrCl) on serum vancomycin concentrations to define a possible optimal dosage regimen in overweight patients based on data obtained during therapeutic drug monitoring. Methods: This retrospective study used data collected from January 2017 to January 2019. Adult patients (n=204) received vancomycin treatment at a dose of 1000 mg every 12 h and underwent serum monitoring. Data collected included patient disease category, sex, age, height, weight, vancomycin concentrations, and serum creatinine. The CrCl values were estimated using the Cockcroft–Gault formula. In this study, statistical comparisons were performed on the results of patients according to serum vancomycin concentration. Results: Serum vancomycin concentration was significantly related to BMI (P < 0.001) and CrCl (P < 0.05) in adult patients. Furthermore, the trough serum vancomycin concentration showed a logarithmic correlation with BMI (R = -0.5108, 95% CI: -0.6082 to -0.3982, P < 0.001) and CrCl (R = -0.5739, 95% CI: -0.6616 to -0.4707, P < 0.001). The multivariate analysis showed that BMI and CrCl are independent contributors to the trough vancomycin concentration. Moreover, some of the patients with higher BMI (≥ 24 kg/m2) met the goal trough concentration after an adjustment from 1000 mg every 12 h to 1000 mg every 8 h. Conclusions: Serum vancomycin concentration decreases progressively with increasing BMI and the augmentation in CrCl in adult patients. The trough concentration of vancomycin should be continuously monitored for patients with a BMI ≥ 24 kg/m2, and the dosage regimen should be adjusted to reach the target trough concentration in these patients to reduce the impact of BMI.

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“…Low vancomycin concentration can lead to treatment failure, so it is necessary to study the correlation between BMI and the concentration of vancomycin. Indeed, there were studies already had shown that Vd was associated with BMI, and drug clearance (CL) had a positive correlation with CrCl [25,26]. Hence, we speculate that the effect of BMI on vancomycin concentration may be achieved by affecting the Vd, while the effect of CrCl on vancomycin concentration was mainly achieved by affecting the drug CL.…”

Section: Discussionmentioning

confidence: 82%

The effect of body mass index and creatinine clearance on serum trough concentration of vancomycin in adult patients

Pan

Yao

et al. 2020

BMC Infect Dis

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Background: The aim of this study was to evaluate the influence of patient body mass index (BMI) and estimated creatinine clearance (CrCl) on serum vancomycin concentrations to define a possible optimal dosage regimen in overweight patients based on data obtained during therapeutic drug monitoring. Methods: This retrospective study used data collected from January 2017 to January 2019. Adult patients (n = 204) received vancomycin treatment at a dose of 1000 mg every 12 h and underwent serum monitoring. Data collected included patient disease category, sex, age, height, weight, vancomycin concentrations, and serum creatinine. The CrCl values were estimated using the Cockcroft-Gault formula. In this study, statistical comparisons were performed on the results of patients according to serum vancomycin concentration. Results: Serum vancomycin concentration was significantly related to BMI (P < 0.001) and CrCl (P < 0.05) in adult patients. Furthermore, the trough serum vancomycin concentration showed a logarithmic correlation with BMI (R = − 0.5108, 95% CI: − 0.6082 to − 0.3982, P < 0.001) and CrCl (R = − 0.5739, 95% CI: − 0.6616 to − 0.4707, P < 0.001). The multivariate analysis showed that BMI and CrCl are independent contributors to the trough vancomycin concentration. Moreover, some of the patients with higher BMI (≥ 24 kg/m 2) met the goal trough concentration after an adjustment from 1000 mg every 12 h to 1000 mg every 8 h. Conclusions: Serum vancomycin concentration decreases progressively with increasing BMI and the augmentation in CrCl in adult patients. The trough concentration of vancomycin should be continuously monitored for patients with a BMI ≥ 24 kg/m 2 , and the dosage regimen should be adjusted to reach the target trough concentration in these patients to reduce the impact of BMI.

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Population pharmacokinetics of peginterferon α2a in patients with chronic hepatitis B

Cited by 5 publications

References 15 publications

Impact of gender, albumin, and CYP2C19 polymorphisms on valproic acid in Chinese patients: a population pharmacokinetic model

Impact of gender, albumin, and CYP2C19 polymorphisms on valproic acid in Chinese patients: a population pharmacokinetic model

The effect of body mass index and creatinine clearance on serum trough concentration of vancomycin in adult patients

The effect of body mass index and creatinine clearance on serum trough concentration of vancomycin in adult patients

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