Population Pharmacokinetics of Periarticular Ketorolac in Adult Patients Undergoing Total Hip or Total Knee Replacement Surgery

Abstract

Our study demonstrates that with periarticular infiltration, S (-) ketorolac was observed to have increased clearance rate and highly variable volume of distribution and lower peak plasma concentration compared to R (+) ketorolac.

Ketorolac tromethamine pretreatment suppresses sufentanil-induced cough during general anesthesia induction: a prospective randomized controlled trial

“…Studies by Yang HL et al suggested that injection of ketorolac tromethamine before tracheal intubation can reduce the incidence of sore throat caused by endotracheal intubation from 71.6 to 21.1% [23]. Compared with other NSAIDs, ketorolac tromethamine has a weaker anti-inflammatory effect and stronger analgesic effect and has been widely used in the clinic [10,24]. In this study, ketorolac tromethamine significantly reduced the number of patients with VAS scores greater than 3.…”

“…We describe the relevant effects objectively because there is no relevant report about ketorolac tromethamine injection or other nonsteroidal drugs inhibiting sufentanil-induced cough. Second, the pretreatment dose of ketorolac tromethamine that was used (0.5 mg/ kg) may not be the most appropriate dose for ketorolac tromethamine to inhibit the sufentanil-induced cough response, but it was given according to the early postoperative analgesic dose recommended in the drug instructions [10]. Third, our study was a single center study with a small sample size.…”

“…It has been reported that intravenous injection of dezocine before anesthesia induction can inhibit the cough response induced by sufentanil or fentanyl to some extent by activating the K receptor and inhibiting histamine release [ 5 ]. Considering that ketorolac tromethamine is a nonsteroidal anti-inflammatory drug, the mechanism of a ketorolac tromethamine injection reducing the cough response may be related to the reduction of histamine release and other reasons [ 10 ].…”

“…Alexander T et al reported that a moderate dose of aspirin (500 mg/day) could reduce angiotensin converting enzyme inhibitor-induced cough [ 9 ]. Ketorolac tromethamine is a new nonsteroidal anti-inflammatory and analgesic drug that is widely used in the short-term treatment of acute moderate and severe pain, including postoperative incision pain [ 10 , 11 ]. At present, the clinical effect and safety of ketorolac tromethamine for suppressing sufentanil-induced cough during the induction of general anesthesia remain unclear.…”

Clinical research for dose effects of ketorolac tromethamine on PCIA after hip arthroplasty

“…Nteroidal anti-inflammatory drugs (NSAIDs) play important roles in the multimodal analgesic protocol (Moizo et al, 2004;Ismail et al, 2020;Özden & Kiliç, 2020;Yuwa-Amornpitak et al, 2020). Ketorolac tromethamine, otherwise known as ketorolac, is a NSAID and a pyrrolizine carboxylic acid derivative (Gurunathan et al, 2018). It is currently one of the most effective non-steroidal anti-inflammatory drugs and widely used in adult postoperative analgesia (Lee et al, 2010).…”