Population PK/PD Analysis

Concordet, Didier; Ané, Cécile; Leger, Frédéric

doi:10.3109/9781439822463.164

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…Catenary chains of compartments, as depicted in figure 5, are widely used in the literature by kineticists for the modelling of anticancer drug toxicity, see for instance [6,7,14,15,16,17] and references therein. Most anticancer drugs have toxic effects on white blood cells (myelosuppression).…”

Section: A Pharmacokinetics/pharmacodynamics Example In Cancerologymentioning

confidence: 99%

“…In order to mimic practical situations, we used a synthetic dataset obtained by perturbing a dataset extracted from [6] (we did not have the permission to use directly the dataset of [6]). In this study, an anticancer drug was administrated by 30-min intravenous infusions to patients, on five consecutive days, see figure 8.…”

Section: A Pharmacokinetics/pharmacodynamics Example In Cancerologymentioning

confidence: 99%

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Explicit Formulas for a Continuous Stochastic Maturation Model: Application to Anticancer Drug Pharmacokinetics/Pharmacodynamics

Chafäı

Concordet

2008

Stochastic Models

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We present a continuous time model of maturation and survival, obtained as the limit of a compartmental evolution model when the number of compartments tends to infinity. We establish in particular an explicit formula for the law of the system output under inhomogeneous killing and when the input follows a time-inhomogeneous Poisson process. This approach allows the discussion of identifiability issues which are of difficult access for finite compartmental models. The article ends up with an example of application for anticancer drug pharmacokinetics/pharmacodynamics.

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Section: A Pharmacokinetics/pharmacodynamics Example In Cancerologymentioning

confidence: 99%

Section: A Pharmacokinetics/pharmacodynamics Example In Cancerologymentioning

confidence: 99%

Explicit Formulas for a Continuous Stochastic Maturation Model: Application to Anticancer Drug Pharmacokinetics/Pharmacodynamics

Chafäı

Concordet

2008

Stochastic Models

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“…Additionally, it is able to limit the requirements of sampling designs by applying mixed-effects modeling approaches ( Taubert et al, 2018 ). Moreover, Pop PK approaches are useful to predict a typical PK profile for any given patient when a sufficient knowledge of covariates is available ( Concordet et al, 2004 ).…”

Section: Introductionmentioning

confidence: 99%

Population Pharmacokinetic Model of Iohexol in Dogs to Estimate Glomerular Filtration Rate and Optimize Sampling Time

et al. 2021

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Monitoring iohexol plasma clearance is considered a useful, reliable, and sensitive tool to establish glomerular filtration rate (GFR) and early stages of kidney disease in both humans and veterinary medicine. The assessment of GFR based on iohexol plasma clearance needs repeated blood sampling over hours, which is not easily attainable in a clinical setting. The study aimed to build a population pharmacokinetic (Pop PK) model to estimate iohexol plasma clearance in a population of dogs and based on this model, to indicate the best sampling times that enable a precise clearance estimation using a low number of samples. A Pop PK model was developed based on 5 iohexol plasma samples taken from 5 to 180 minutes (min) after an intravenous iohexol nominal dose of 64.7 mg/kg from 49 client-owned dogs of different breeds, sexes, ages, body weights, and clinical conditions (healthy or presenting chronic kidney disease CKD). The design of the best sampling times could contain either 1 or 2 or 3 sampling times. These were discretized with a step of 30 min between 30 and 180 min. A two-compartment Pop PK model best fitted the data; creatinine and kidney status were the covariates included in the model to explain a part of clearance variability. When 1 sample was available, 90 or 120 min were the best sampling times to assess clearance for healthy dogs with a low creatinine value. Whereas for dogs with CKD and medium creatinine value, the best sampling time was 150 or 180 min, for CKD dogs with a high creatinine value, it was 180 min. If 2 or 3 samples were available, several sampling times were possible. The method to define the best sampling times could be used with other Pop PK models as long as it is representative of the patient population and once the model is built, the use of individualized sampling times for each patient allows to precisely estimate the GFR.

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Mobile Number Portability in South Asia

Iqbal¹

2010

SSRN Journal

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Population PK/PD Analysis

Cited by 3 publications

References 9 publications

Explicit Formulas for a Continuous Stochastic Maturation Model: Application to Anticancer Drug Pharmacokinetics/Pharmacodynamics

Explicit Formulas for a Continuous Stochastic Maturation Model: Application to Anticancer Drug Pharmacokinetics/Pharmacodynamics

Population Pharmacokinetic Model of Iohexol in Dogs to Estimate Glomerular Filtration Rate and Optimize Sampling Time

Mobile Number Portability in South Asia

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