Population Survey on Cerebrovascular and Cardiovascular Diseases

Kimura, Noboru; Toshima, Hironori; Nakayama, Yuhki; Mizuguchi, Tadanobu; Takayama, Kazushige; Yoshinaga, Mitsuhiro; Fukami, Tsukasa; Tashiro, Hiromi; KATAYAMA, Fumizi; Abe, Ken; Arima, Tadashi; Yokota, Yukio; Minagawa, Eiji; Tanaka, Ryo; Akiyoshi, Toshinori; Soejima, Kuninori; Yamada, Kensuke; Mizunoe, Akihide; Nakamura, Kazunori; Oshima, Fumio; Tanaka, Kiyoshi; Akasu, Kenjiro; Niizaki, Taketoshi; Ikeda, Hideo; NAKAMICHI, Eiji; Ageta, Masato; MIIKE, Yoshiro; Inoue, Tetsuro; NAKAGAWA, Takashi; Nanbu, Seiki; Tanioka, Terutoshi; Shimada, Susumu; Fukumoto, Terunori

doi:10.1536/ihj.13.118

Cited by 11 publications

(2 citation statements)

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“…Yamori's findings are intriguing since epidemiologists have shown that the unusually high incidence of hypertension and strokes among the Japanese may be related to their high carbohydrate and salt intake (highest in the world), high fish consumption, and low protein intake. 9 In Japan, hypertension and stroke is more prevalent in rural areas than in large cities. 10 Stroke in Japan is not associated with obesity or abnormal lipid metabolism but is best correlated with the high ingestion of soy sauce and salt, rice with miso soup (mix of soybeans, yeast and salt), pickles with tea, and highly salted fish, while the ingestion of apples (high in potassium) is associated with a lower incidence of hypertension and stroke.…”

Section: Pathologymentioning

confidence: 99%

Low protein fish vs low protein animal diet enhances the propensity for stroke in stroke-prone/SHR.

Wexler¹

1983

Stroke

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SUMMARY Weanling male and female, stroke-prone, spontaneously hypertensive rats (SHR/SP) were fed: 1) regular commercial rat chow, 2) low protein fish diet, 3) low protein fish diet +1% saline, 4) low protein animal diet, and 5) low protein animal diet + 1 % saline. The blood pressure of all of the SHR/SP rose rapidly reaching 240 mmHg at 90 days of age; blood pressure of low protein fish diet +1% saline-fed SHR/SP rose most rapidly, reaching levels ranging from 258 to 300 mmHg. All of these animals developed acute strokes by 90 days of age; none of the other diet-fed SHR/SP manifested cerebral damage. The protein poor diets prevented normal growth, caused hypogonadism, and severely reduced pituitary and adrenal gland weights. The low protein diets were stressful causing significantly increased secretion of adrenocorticotrophic hormone and marked increases in triglyceride, free fatty acid, cholesterol, glucose, and B.U.N, levels. The mixed hemorrhagic-thrombogenic cerebral lesions occurred ipsilaterally in the parietal lobe, involved basal ganglia, and appeared in areas of brain tissue nourished by the middle cerebral artery. It is concluded that the inclusion of 1% saline drinking water with a low protein diet offish tissue origin specifically, was synergistic in enhancing the propensity of SHR/SP rats to develop their geneticallyprogrammed hypertension and stroke.

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Section: Pathologymentioning

confidence: 99%

Low protein fish vs low protein animal diet enhances the propensity for stroke in stroke-prone/SHR.

Wexler¹

1983

Stroke

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“…In certain Japanese populations, cerebrovascular complications, which are associated with high salt/low protein diets [13]. The effect of dietary salt on hypertension [13] and maternal protein deficiency on behavioral parameters in children [14][15][16] suggest that a great segment of the population may consume food with high salt/low protein content.…”

Section: Introductionmentioning

confidence: 99%

Effects of Perinatal Protein-Nacl Diets on Offspring's Blood Pressure and Renal Function in Lewis Rats

Lee¹,

Azar²

2013

TOHYPERJ

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Perinatal diets may affect the cardiovascular-renal functions of offspring. To understand effects of maternal diet on the renal function and blood pressure (BP) of offspring, protein (10% low, LP; 23% normal, NP) and/or NaCl (4% high salt, HS; 0.6% normal, NS) diets were started at pre-pregnancy through pups' weaning to either a 4% high NaCl (hs) or 0.6% NaCl (ns) diet. Telemetered BP data was analyzed by methods of linear least square rhythmometry. Systolic BPs (circadian mean ±SE mm Hg) were: NPNSns, 131±2; NPNShs, 137±2; NPHSns, 137±0.2; NPHShs, 134±3; LPNSns, 138±1; LPNShs, 138±0.6; LPHSns, 135±2; LPHShs, 142±2. Offspring in NPNShs and NPHSns had significantly increased SBPs versus NPNSns (both P<0.05). Most LP-offspring had increased SBP (P<0.01 to <0.05) and lower body weight (BW) with smaller glomerular filtration rate changes (renal reserve, RR-GFR) following overnight acute highprotein loads: RR-GFRs (inulin, ml/min/g kidney) for groups stated above were, respectively: 0.935; 0.927; 0.537; -0.064; -0.229; 0.057; -0.515; -0.404. The kidney weight/BW ratio of offspring was higher on hs-than on ns-diets (all P<0.001). Rats on a low caloric diet had reduced sclerotic glomerular numbers compared to those on normal diets (11.2±1 vs. 15.7±2, P<0.001), though glomerular numbers were similar in both groups.In summary, perinatal LP-HS diets significantly affected the BW, BP, renal injuries and kidney function of offspring. RR was seriously reduced, especially among offspring in hs-and perinatal LP groups. The most interesting result was the glomerular maturation staging in the pups, which suggests delayed nephrogenesis by a maternal LP diet.

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2004

Nutrition and Stroke

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Population Survey on Cerebrovascular and Cardiovascular Diseases

Cited by 11 publications

References 0 publications

Low protein fish vs low protein animal diet enhances the propensity for stroke in stroke-prone/SHR.

Low protein fish vs low protein animal diet enhances the propensity for stroke in stroke-prone/SHR.

Effects of Perinatal Protein-Nacl Diets on Offspring's Blood Pressure and Renal Function in Lewis Rats

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