Porcine C‐peptide measurement to assess graft function in xenogeneic porcine islet transplantation; editorial commentary

The value of glycated albumin for the prediction of graft outcome in the non‐human primate porcine islet transplantation model

“…Blood glucose and C‐peptide levels physiologically vary throughout the day. Moreover, the measurement of porcine C‐peptide is not fully standardized and validated . The lack of a precise and easy‐to‐use monitoring tool for islet graft function makes it difficult to infer a possible mechanism of islet damage and to develop an appropriate therapy …”

Xenotransplantation literature update, September/October 2017

“…Schuurman provided an editorial commentary on the porcine C‐peptide manuscript . The take home messages were the following: (i) porcine C‐peptide assay has been validated by an independent lab and in principle can be used for porcine xenogeneic islet cell transplants, (ii) there is an algorithm to convert between RIA and ELISA data, (iii) the outcomes of the assays may not represent true absolute concentration of C‐peptide thus requiring the development of a porcine c‐peptide standards that meet international and regulatory criteria, and (iv) sole analysis of c‐peptide of serum may be misleading and that other tissues or fluids may be more informative.…”