Porcine Dermal Collagen Prevents Seroma Formation After Mastectomy and Axillary Dissection in Rats

Ağalar, Cihan; Sevinç, Ali İbrahim; Aysal, Anıl; Egeli, Tufan; Aksoy, Özkan Süleyman; Koçdor, Mehmet Ali

doi:10.5152/ejbh.2017.3616

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…These findings led us think that clinoptilolite application in the study group did not have an effect on formation of inflammatory seroma. Studies about clinoptilolite in the literature emphasize its effects in hemostatic control, that further gives rise to efficiency in seroma control (31).…”

Section: Analytical Proceduresmentioning

confidence: 99%

Effects of locally applied Clinoptilolite (Froximun®) on seroma formation in a rat mastectomy and axillary lymph node dissection model

Aksoy¹,

Tunk²,

Sevinç³

et al. 2019

Deu Med J

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Objective: Seroma formation is one of the most frequent complications following breast cancer surgery. Although many techniques and drugs have been investigated, no definitive data are available concerning how to prevent this complication. The present study aims to investigate impact of local clinoptilolite application on seroma formation in an experimental mastectomy model created in rats. Material and Method: Two groups with seven rats in each were randomised. Under general anesthesia, all rats underwent right mastectomy and axillary dissection. Clinoptilolite was locally applied to surgical sites in the study group, whereas no application was performed in the control group. Ten days after the surgery, seroma formation was evaluated and tissue samples were obtained from the surgical sites, for both biochemical and histopathological examination Results: There was statistically significant decrease in seroma formation after clinoptilolite application (p=0.002). In addition, granulation tissue formation was significantly higher in the study group (p=0.006). No statistical difference was found between groups in terms of biochemical parameters. Conclusion: The reducing effect of seroma formation by clinoptilolite application may be due to its crystal cage structure. It collects seroma with its sero-absorbent features and creates granuloma formation that reduces dead-space, therefore accelarating wound healing.

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Section: Analytical Proceduresmentioning

confidence: 99%

Effects of locally applied Clinoptilolite (Froximun®) on seroma formation in a rat mastectomy and axillary lymph node dissection model

Aksoy¹,

Tunk²,

Sevinç³

et al. 2019

Deu Med J

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show abstract

“…Techniques and technologies to obliterate surgical dead space are varied and include suture anchors, 60 tissue adhesives, quilting sutures, and NPWT 61 . In vivo studies have demonstrated that the addition of bioscaffold materials to surgical dead space reduces seroma formation in a dose-dependent manner 62 …”

Section: Literature Synthesismentioning

confidence: 99%

“…61 In vivo studies have demonstrated that the addition of bioscaffold materials to surgical dead space reduces seroma formation in a dosedependent manner. 62 Based on the current clinical evidence, the working group concluded:…”

Section: Surgical Intervention For Stage 3 or 4 Pismentioning

confidence: 99%

Surgical Reconstruction of Stage 3 and 4 Pressure Injuries: A Literature Review and Proposed Algorithm from an Interprofessional Working Group

Awad

Stern

Milne

et al. 2023

Adv Skin Wound Care

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OBJECTIVE:Stage 3 and 4 pressure injuries (PIs) present an enormous societal burden with no clearly defined interventions for surgical reconstruction. The authors sought to assess, via literature review and a reflection/evaluation of their own clinical practice experience (where applicable), the current limitations to the surgical intervention of stage 3 or 4 PIs and propose an algorithm for surgical reconstruction. METHODS:An interprofessional working group convened to review and assess the scientific literature and propose an algorithm for clinical practice. Data compiled from the literature and a comparison of institutional management were used to develop an algorithm for the surgical reconstruction of stage 3 and 4 PIs with adjunctive use of negative-pressure wound therapy and bioscaffolds.RESULTS: Surgical reconstruction of PI has relatively high complication rates. The use of negative-pressure wound therapy as adjunctive therapy is beneficial and widespread, leading to reduced dressing change frequency. The evidence for the use of bioscaffolds both in standard wound care and as an adjunct to surgical reconstruction of PI is limited. The proposed algorithm aims to reduce complications typically seen with this patient cohort and improve patient outcomes from surgical intervention. CONCLUSIONS:The working group has proposed a surgical algorithm for stage 3 and 4 PI reconstruction. The algorithm will be validated and refined through additional clinical research.

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The Effects of Platelet-Rich Plasma to Decrease the Risk of Seroma Formation After Mastectomy and Axillary Dissection

Çalışır

Ece

Yormaz

et al. 2020

Journal of Surgical Research

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Porcine Dermal Collagen Prevents Seroma Formation After Mastectomy and Axillary Dissection in Rats

Cited by 3 publications

References 17 publications

Effects of locally applied Clinoptilolite (Froximun®) on seroma formation in a rat mastectomy and axillary lymph node dissection model

Effects of locally applied Clinoptilolite (Froximun®) on seroma formation in a rat mastectomy and axillary lymph node dissection model

Surgical Reconstruction of Stage 3 and 4 Pressure Injuries: A Literature Review and Proposed Algorithm from an Interprofessional Working Group

The Effects of Platelet-Rich Plasma to Decrease the Risk of Seroma Formation After Mastectomy and Axillary Dissection

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