Porcine Noroviruses Related to Human Noroviruses

Wang, Qiuhong; Han, Myung Guk; Cheetham, Sonia; Souza, Menira; Funk, Julie A.; Saif, Linda J.

doi:10.3201/eid1112.050485

Cited by 214 publications

(233 citation statements)

References 29 publications

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“…However, no information on NoV in pigs was available. In 1998, NoV RNA was first detected from adult pig cecal samples in Japan, and later in Europe and the US [13][14][15]. Subsequently, NoVs were found to be widely distributed in healthy adult pigs [16].…”

Section: History Of Enteric Caliciviruses and The Discovery Of Pormentioning

confidence: 99%

“…The full name of a NoV or SaV strain is organized as follows: Host species from which the virus was obtained/ genus/genogroup-genotype/strain name/year of occurance/country of origin [1]. The classification and GenBank accession numbers of representative NoV and SaV strains were summarized in two published papers [15,50].…”

Section: Genetic Organization and Classification Of Novs And Savsmentioning

confidence: 99%

“…Recently, porcine NoVs QW101/2003/US and QW170/2003/US were identified from US swine [15]. At the amino acid level, their complete capsid proteins share 71% sequence identity to each other, and share 61-71% and 62-81% identity, respectively, to other genotypes of NoVs including the GII-11 porcine NoV Sw43 strain.…”

Section: Genetic Classification Of Porcine Novsmentioning

confidence: 99%

“…This conserved nucleotide motif is almost identical within each genogroup of NoVs and SaVs, probably facilitating homologous recombination during co-infection of a cell by different genotypes of NoVs or SaVs within the same genogroup. In fact, recombinant NoVs having a recombination site at the RdRp-capsid junction region were identified in humans, calves and pigs [15,48,[59][60][61][62][63]. Two porcine NoVs, QW170 and QW218 strains, which share 99% nt identity at the 3'-end 3kb sequence of the genome, were reported as potential recombinants [15].…”

Section: Recombination Of Porcine Novs and Savsmentioning

confidence: 99%

“…In fact, recombinant NoVs having a recombination site at the RdRp-capsid junction region were identified in humans, calves and pigs [15,48,[59][60][61][62][63]. Two porcine NoVs, QW170 and QW218 strains, which share 99% nt identity at the 3'-end 3kb sequence of the genome, were reported as potential recombinants [15]. They showed high sequence identity to GII-11/Sw43 strain in the RdRp region but the identity dropped abruptly at the RdRp-capsid junction region.…”

Section: Recombination Of Porcine Novs and Savsmentioning

confidence: 99%

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Porcine enteric caliciviruses: Genetic and antigenic relatedness to human caliciviruses, diagnosis and epidemiology

Wang

Costantini

Saif

2007

Vaccine

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Porcine enteric caliciviruses include sapoviruses and noroviruses. Porcine sapoviruses infect pigs of all ages and cause diarrhea in young pigs, whereas porcine noroviruses were detected exclusively from adult pigs without clinical signs. Importantly, certain porcine norovirus strains were genetically and antigenically related to human noroviruses. This raises public health concerns that pigs may be reservoirs for emergence of epidemic human norovirus strains. This article reviews the discovery of porcine noroviruses and sapoviruses, their classification, diagnosis, epidemiology and genetic and antigenic relatedness to human caliciviruses.

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Section: History Of Enteric Caliciviruses and The Discovery Of Pormentioning

confidence: 99%

Section: Genetic Organization and Classification Of Novs And Savsmentioning

confidence: 99%

Section: Genetic Classification Of Porcine Novsmentioning

confidence: 99%

Section: Recombination Of Porcine Novs and Savsmentioning

confidence: 99%

Section: Recombination Of Porcine Novs and Savsmentioning

confidence: 99%

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Porcine enteric caliciviruses: Genetic and antigenic relatedness to human caliciviruses, diagnosis and epidemiology

Wang

Costantini

Saif

2007

Vaccine

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Caliciviruses

Neill¹

2011

Encyclopedia of Life Sciences

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The Caliciviridae is a family of small, nonenveloped viruses containing a single‐stranded, plus‐sense genomic ribonucleic acid (RNA) that is polyadenylated at its 3′‐end. Most, but not all, caliciviruses have distinctive cup‐shaped depressions (L. calix , cup) on their surface, giving them their characteristic ‘Star of David’ appearance by negative‐stain electron microscopy. The calicivirus nonstructural proteins are encoded in the 5′‐end of the genomic RNA and the structural proteins in the 3′‐end. The structural proteins are translated primarily from an abundant subgenomic RNA that is transcribed from the genomic RNA. The identity of several of the nonstructural proteins was made based on amino acid sequence similarities with other virus families. The caliciviruses encode a single capsid protein that forms the outer shell of the virus particle. These viruses have a large and diverse host range and cause diseases of both human and veterinary importance. Key Concepts: Caliciviruses constitute a unique family of viruses. Caliciviruses have significant genetic diversity. Calicivirusesare important agents of disease in both man and animals.

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