2023
DOI: 10.3390/v15030773
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Porcine Reproductive and Respiratory Syndrome Virus Modulates the Switch of Macrophage Polarization from M1 to M2 by Upregulating MoDC-Released sCD83

Abstract: Porcine reproductive and respiratory syndrome virus (PRRSV), the most economically important infectious disease of pigs, elicits poor innate and adaptive immune responses. Soluble CD83 (sCD83), a secretion from various immune cell populations, especially MoDCs, is involved in negatively regulating the immune response. We speculate sCD83 may be a critical factor in the process of PRRSV-coordinated macrophage polarization. In this study, we found that PAMs co-cultured with PRRSV-infected MoDCs inhibited the M1 m… Show more

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Cited by 4 publications
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“…It causes reproductive disorders and breathing difficulties in pigs, generating huge economic loss to the swine industry ( 2 ). The PRRSV genome contains 11 ORFs, encoding eight structural proteins and 16 nonstructural proteins (nsp), each possessing diverse functions in various steps of infection, replication, virulence, and virus–host interactions ( 3 , 4 , 5 , 6 , 7 , 8 ). Immunosuppression after PRRSV infection may contribute to inefficient innate and acquired immune responses, modulating the expression and release of inflammatory and/or anti-inflammatory factors, upregulating immunosuppressive cytokines expression, and allowing the viruses to rapidly reproduce and cause disease ( 9 , 10 , 11 , 12 ).…”
mentioning
confidence: 99%
“…It causes reproductive disorders and breathing difficulties in pigs, generating huge economic loss to the swine industry ( 2 ). The PRRSV genome contains 11 ORFs, encoding eight structural proteins and 16 nonstructural proteins (nsp), each possessing diverse functions in various steps of infection, replication, virulence, and virus–host interactions ( 3 , 4 , 5 , 6 , 7 , 8 ). Immunosuppression after PRRSV infection may contribute to inefficient innate and acquired immune responses, modulating the expression and release of inflammatory and/or anti-inflammatory factors, upregulating immunosuppressive cytokines expression, and allowing the viruses to rapidly reproduce and cause disease ( 9 , 10 , 11 , 12 ).…”
mentioning
confidence: 99%