Porcupine-inspired microneedles coupled with an adhesive back patching as dressing for accelerating diabetic wound healing

Liu, Tianqi; Sun, Yanfang; Jiang, Guohua; Zhang, Wenjing; Wang, Rui; Nie, Lei; Shavandi, Amin; Yunusov, Khaydar E.; Aharodnikau, Uladzislau E.; Solomevich, Sergey O.

doi:10.1016/j.actbio.2023.01.059

Cited by 47 publications

(21 citation statements)

References 73 publications

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“…[ 14 ] In addition, pH, temperature, and presence of salts favor the formation of different chemical bonds with the tissue surfaces. [ 32 ] Although there are other factors such as topography [ 40 ] and mechanics (e.g., use of microneedles) [ 41 ] that may affect adhesion, [ 42 ] the most extensively studied mechanisms are based on the chemistry of the adhesion process. [ 38 ] In addition, it is important to also note that the chemistry behind the adhesive nature of bioadhesives is usually closely related to their cohesive nature.…”

Section: Antimicrobial Bioadhesive Design Requirementsmentioning

confidence: 99%

Bioadhesives with Antimicrobial Properties

et al. 2023

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Bioadhesives with antimicrobial properties enable easier and safer treatment of wounds as compared to the traditional methods such as suturing and stapling on a variety of medical conditions. Composed of natural or synthetic polymers, these bioadhesives seal wounds and facilitate healing while preventing infections through the activity of locally released antimicrobial drugs, nanocomponents or inherently antimicrobial polymers. Although many different materials and strategies are employed to develop antimicrobial bioadhesives, the design of these biomaterials necessitates a prudent approach as achieving all the required properties including optimal adhesive and cohesive properties, biocompatibility, and antimicrobial activity can be challenging. Designing antimicrobial bioadhesives with tunable physical, chemical and biological properties will shed light on the path for future advancement of bioadhesives with antimicrobial properties. In this review, we discuss the requirements and commonly used strategies for developing bioadhesives with antimicrobial properties. In particular, we will summarize different methods for their synthesis and will review their experimental and clinical applications on a variety of organs. Advances in the design of bioadhesives with antimicrobial properties will pave the way for a better management of wounds to increase positive medical outcomes.This article is protected by copyright. All rights reserved

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Section: Antimicrobial Bioadhesive Design Requirementsmentioning

confidence: 99%

Bioadhesives with Antimicrobial Properties

et al. 2023

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“…66 Liu et al loaded an antidiabetic drug (metformin) into a hedgehog-inspired multi-layer MN patch to reduce local blood sugar concentrations to accelerate wound healing. 67 Providing directional mechanical force to promote wound contraction is also beneficial for wound healing. Inspired, researchers developed MN patches of shark tooth-like ( Fig.…”

Section: Designs Of Mn Patches For Diabetic Wound Treatmentmentioning

confidence: 99%

Advances of Microneedle Patch in Diabetic Wound Healing

Zeng,

Jin,

2023

Pharmaceutical Fronts

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Wound healing is an intricate and orderly process of events that occur in response to external trauma, resulting in tissue repair and reconstruction. This process typically involves three phases, including inflammation, angiogenesis, and extracellular matrix remodeling, and any disruption to this process may delay the healing of the wound. Chronic wounds associated with diabetes, in particular, are notorious because they are difficult to handle in a timely and orderly manner. During the treatment of the disease, drugs usually accumulate in the stratum corneum due to the skin barrier, leading to a reduction of the drug's bioavailability. Encouragingly, among the treatment strategies, microneedles (MNs) represent a novel and painless drug delivery method that promotes wound healing in diabetic patients by enabling the drug to reach the dermal layer efficiently. In this review, recent advances of MNs in the treatment of diabetic wound healing are summarized by categorizing the designs and strategies. We finally provide an outlook on the prospects and challenges of MN-based therapies for diabetic wound healing in the future.

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“…Microneedles (MNs) are a transdermal drug delivery system that can penetrate the stratum corneum of the skin, allowing drugs to enter the systemic circulation through capillaries to achieve therapeutic purposes. [18][19][20][21][22] Therefore, it can eliminate the first-pass metabolism and improve the drug utilization. 23 Additionally, the MN system provides a safer and painless alternative to subcutaneous injections, which can avoid unexpected side effects and improve the patient's compliance.…”

Section: Introductionmentioning

confidence: 99%