Porogen Effect of Solvents on Pore Size Distribution of Solvent-Casted Polycaprolactone Thin Films

Safaei, Fariba; Khalili, Shahla; Khorasani, Saied Nouri; Ghasemi‐Mobarakeh, Laleh; Neisiany, Rasoul Esmaeely

doi:10.24294/jpse.v1i4.1076

Cited by 6 publications

(9 citation statements)

References 16 publications

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“…The high solvent evaporation rate (boiling point 39.6 °C) induced specimens with body deformation, air bubbles, inhomogeneous surfaces, irregular shape, and dimensional shrinkage [ 44 ]. The solvent molecules diffusion fast generated smooth and dense surfaces, as can be seen in Figure 2 D. Although nonpolar organic solvent facilitates the PCL solubilization process due to higher solvent-polymer chemical affinity, the low difference between its solubility parameters ((δ = 0.05 (cal cm −3 ) ½ ) can make difficult the mass transport of volatile and the use of DCM as a porogen [ 46 ].…”

Section: Resultsmentioning

confidence: 99%

PCL/Andiroba Oil (Carapa guianensis Aubl.) Hybrid Film for Wound Healing Applications

et al. 2021

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Developing a biomimetic material to wound care is an emerging need for the healing process. Poly (ε-caprolactone) (PCL) is a polymer with the necessary dressing’s requirements often used in medicine. Their surface, physic-chemical and biological properties can be modified by adding bioactive compounds, such as andiroba seed oil (Carapa guianensis). This Amazonian natural plant has medicinal and pharmacological properties. For this purpose, PCL polymeric films incorporated with andiroba oil were investigated. The synthesis of hybrids materials was carried out in the solvent casting method. Thermal properties were evaluated using thermogravimetric analysis (TGA/DTGA) and differential scanning calorimetry (DSC). The solvent type on the surface and hydrophilicity of samples was studied using a scanning electron microscope (SEM). Additionally, contact angle measurements, functional groups analysis, fluid absorption capacity, and cell viability were performed. The results demonstrated the influences of andiroba oil under the morphology and thermal properties of the polymeric matrix; the hydrophilicity of the hybrid film obtained by acetic acid was reduced by 13%; the porosity decreased as the concentration of oil increased, but its higher thermal stability. The L929 cell line’s proliferation was observed in all materials, and it presented nontoxic nature. It was demonstrated the ability of PCL hybrid film as a matrix for cell growth. Then, the materials were proved potential candidates for biomedical applications.

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Section: Resultsmentioning

confidence: 99%

PCL/Andiroba Oil (Carapa guianensis Aubl.) Hybrid Film for Wound Healing Applications

et al. 2021

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“…In the solvent casting method, the polymer is dissolved with a suitable solvent, and the mixture is then poured into a mold with the desired shape. Different methods of drying can be applied to remove the solvent, including air drying, vacuum drying, and freeze-drying [26]. During the polymer dissolution step, it is possible to add water-soluble inorganic particles (e.g.…”

Section: Solvent Castingmentioning

confidence: 99%

“…The surface properties of the films prepared by solvent casting depend on the nature of the solvent that is used. The effect of different solvents on the pore size distribution of the polycaprolactone (PCL) thin films was studied [26]. The PCL films were made by dissolving PCL in chloroform (CL), methylene chloride (MC), and three different compositions of dimethylformamide (DMF)/MC.…”

Section: Solvent Castingmentioning

confidence: 99%

“…The porogen properties of the solvents are related to solubility parameters and polarity between the polymer and solvent. Therefore, the non-porogen properties of CL and MC were assigned to good miscibility between PCL and CL and low boiling point of MC, respectively, once a solvent must have a high boiling point to be considered porogen [26]. This is a preliminary study focused on producing materials for tissue engineering.…”

Section: Solvent Castingmentioning

confidence: 99%

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Recent progress on polymer scaffolds production: Methods, main results, advantages and disadvantages

Montanheiro¹,

Schatkoski²,

Menezes³

et al. 2022

Express Polym. Lett.

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Porous polymeric scaffolds provide a physical substrate for cells to attach and proliferate, allowing the formation of new tissue. These materials are broadly used in the tissue engineering field due to their ability to mimic native tissue. Each application requires specific morphologies and resistance, among other several features. To accomplish these requirements, various techniques are available, each one with its advantages and disadvantages. Among the most relevant techniques are salt leaching, solvent casting, gas foaming, thermally induced phase separation, freeze-drying, electrospinning, thermally induced self-agglomeration, and three-dimensional (3D) printing. In this review, a brief and simple explanation of each method is described, along with some recent results and each technique's advantages and disadvantages. It is expected that this review will bring important guidance in the production of polymer scaffolds for tissue engineering.

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“…Because of the solvent physical properties, listed in Table 2, PCL diluted in acetic acid and reinforced with TiO 2 NPs leads to a greater surface area and the appearance of micro pores, as illustrated in Figure 1a,b,c, while the non-solvating chloroform porogenic solvent generates membrane macropores (see Figure 1d,e,f). Based on the solvent physical properties in Table 2 [16,17], chloroform and DMF have a similar boiling point with low solubility parameter differences and exhibits good solubility and miscibility with PCL polymeric material. Therefore, the PCL composite membranes elaborated with this solvent promote more uniform macro pore structure [18][19][20][21].…”

Section: Surface Roughness Measurementsmentioning

confidence: 99%

Development, Fabrication, and Characterization of Composite Polycaprolactone Membranes Reinforced with TiO2 Nanoparticles

et al. 2019

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This paper focuses on developing, fabricating, and characterizing composite polycaprolactone (PCL) membranes reinforced with titanium dioxide nanoparticles (NPs) elaborated by using two solvents; acetic acid and a mixture of chloroform and N,N-dimethylformamide (DMF). The resulting physical, chemical, and mechanical properties of the composite materials are studied by using experimental characterization techniques such as scanning electron microscopy (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD), Fourier-transform infrared (FTIR) analysis, contact angle (CA), uniaxial and biaxial tensile tests, and surface roughness measurements. Experimental results show that the composite material synthesized by sol-gel and chloroform-DMF has a better performance than the one obtained by using acetic acid as a solvent.

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Porogen Effect of Solvents on Pore Size Distribution of Solvent-Casted Polycaprolactone Thin Films

Cited by 6 publications

References 16 publications

PCL/Andiroba Oil (Carapa guianensis Aubl.) Hybrid Film for Wound Healing Applications

PCL/Andiroba Oil (Carapa guianensis Aubl.) Hybrid Film for Wound Healing Applications

Recent progress on polymer scaffolds production: Methods, main results, advantages and disadvantages

Development, Fabrication, and Characterization of Composite Polycaprolactone Membranes Reinforced with TiO2 Nanoparticles

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