Porosity and swelling properties of novel polyurethane–ascorbic acid scaffolds prepared by different procedures for potential use in bone tissue engineering

Kucińska-Lipka, Justyna; Marzec, Mateusz; Gubańska, Iga; Janik, Helena

doi:10.1177/0095244316672093

Cited by 23 publications

(17 citation statements)

References 44 publications

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“…Post immersion, they were dried thoroughly with tissue paper and weighed again to obtain the wet weight (W w ). The following equation was used to calculate the swelling ( L ) of the scaffolds (Shahini et al, 2014; Kucinska-Lipka et al, 2017):…”

Section: Methodsmentioning

confidence: 99%

3D Hybrid Scaffolds Based on PEDOT:PSS/MWCNT Composites

Jayaram

Pitsalidis

et al. 2019

Front. Chem.

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Conducting polymer scaffolds combine the soft-porous structures of scaffolds with the electrical properties of conducting polymers. In most cases, such functional systems are developed by combining an insulating scaffold matrix with electrically conducting materials in a 3D hybrid network. However, issues arising from the poor electronic properties of such hybrid systems, hinder their application in many areas. This work reports on the design of a 3D electroactive scaffold, which is free of an insulating matrix. These 3D polymer constructs comprise of a water soluble conducting polymer (PEDOT:PSS) and multi-walled carbon nanotubes (MWCNTs). The insertion of the MWCNTs in the 3D polymer matrix directly contributes to the electron transport efficiency, resulting in a 7-fold decrease in resistivity values. The distribution of CNTs, as characterized by SEM and Raman spectroscopy, further define the micro- and nano-structural topography while providing active sites for protein attachment, thereby rendering the system suitable for biological/sensing applications. The resulting scaffolds, combine high porosity, mechanical stability and excellent conducting properties, thus can be suitable for a variety of applications ranging from tissue engineering and biomedical devices to (bio-) energy storage.

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Section: Methodsmentioning

confidence: 99%

3D Hybrid Scaffolds Based on PEDOT:PSS/MWCNT Composites

Jayaram

Pitsalidis

et al. 2019

Front. Chem.

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“…On the other hand, the increased isocyanate index in the formulation had caused an increment of pore size from 37–1333 µm (PU 0.8) to 57–1700 µm (PU 1.2), respectively ( Table 3 ). The increased isocyanate index in the polyurethane formulation from 0.8 to 1.2 had increased the pore sizes of the polyurethanes produced due to the combination of two types of conflict forces effect [ 44 ]. Higher amounts of IPDI used in the reaction could lead to the formation of allophanate crosslinking and hence increased the elasticity of the pore channels.…”

Section: Resultsmentioning

confidence: 99%

Production of Biodegradable Palm Oil-Based Polyurethane as Potential Biomaterial for Biomedical Applications

et al. 2020

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Being biodegradable and biocompatible are crucial characteristics for biomaterial used for medical and biomedical applications. Vegetable oil-based polyols are known to contribute both the biodegradability and biocompatibility of polyurethanes; however, petrochemical-based polyols were often incorporated to improve the thermal and mechanical properties of polyurethane. In this work, palm oil-based polyester polyol (PPP) derived from epoxidized palm olein and glutaric acid was reacted with isophorone diisocyanate to produce an aliphatic polyurethane, without the incorporation of any commercial petrochemical-based polyol. The effects of water content and isocyanate index were investigated. The polyurethanes produced consisted of > 90% porosity with interconnected micropores and macropores (37–1700 µm) and PU 1.0 possessed tensile strength and compression stress of 111 kPa and 64 kPa. The polyurethanes with comparable thermal stability, yet susceptible to enzymatic degradation with 7–59% of mass loss after 4 weeks of treatment. The polyurethanes demonstrated superior water uptake (up to 450%) and did not induce significant changes in pH of the medium. The chemical changes of the polyurethanes after enzymatic degradation were evaluated by FTIR and TGA analyses. The polyurethanes showed cell viability of 53.43% and 80.37% after 1 and 10 day(s) of cytotoxicity test; and cell adhesion and proliferation in cell adhesion test. The polyurethanes produced demonstrated its potential as biomaterial for soft tissue engineering applications.

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“…In accordance with previous works [16,30] a two-stage (prepolymer method) synthesis of polyester urethanes (S-TPU(PCL)) was carried out. The first stage of the synthesis was the reaction of the polyol (PCL diol), with an excess of diisocyanate (HDI) resulting in a prepolymer mixture containing an isocyanate terminated prepolymer (building soft segments) and an excess of unreacted diisocyanate.…”

Section: Methodsmentioning

confidence: 97%

Medical-Grade PCL Based Polyurethane System for FDM 3D Printing—Characterization and Fabrication

et al. 2019

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The widespread use of three-dimensional (3D) printing technologies in medicine has contributed to the increased demand for 3D printing materials. In addition, new printing materials that are appearing in the industry do not provide a detailed material characterization. In this paper, we present the synthesis and characterization of polycaprolactone (PCL) based medical-grade thermoplastic polyurethanes, which are suitable for forming in a filament that is dedicated to Fused Deposition Modeling 3D (FDM 3D)printers. For this purpose, we synthesized polyurethane that is based on PCL and 1,6-hexamethylene diisocyanate (HDI) with a different isocyanate index NCO:OH (0.9:1, 1.1:1). Particular characteristics of synthesized materials included, structural properties (FTIR, Raman), thermal (differential scanning calorimetry (DSC), thermogravimetric analysis (TGA)), mechanical and surfaces (contact angle) properties. Moreover, pre-biological tests in vitro and degradation studies were also performed. On the basis of the conducted tests, a material with more desirable properties S-TPU(PCL)0.9 was selected and the optimization of filament forming via melt-extrusion process was described. The initial biological test showed the biocompatibility of synthesized S-TPU(PCL)0.9 with respect to C2C12 cells. It was noticed that the process of thermoplastic polyurethanes (TPU) filaments forming by extrusion was significantly influenced by the appropriate ratio between the temperature profile, rotation speed, and dosage ratio.

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Porosity and swelling properties of novel polyurethane–ascorbic acid scaffolds prepared by different procedures for potential use in bone tissue engineering

Cited by 23 publications

References 44 publications

3D Hybrid Scaffolds Based on PEDOT:PSS/MWCNT Composites

3D Hybrid Scaffolds Based on PEDOT:PSS/MWCNT Composites

Production of Biodegradable Palm Oil-Based Polyurethane as Potential Biomaterial for Biomedical Applications

Medical-Grade PCL Based Polyurethane System for FDM 3D Printing—Characterization and Fabrication

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