We conducted a 3‐D seismic inversion study to investigate spatial variations of physical properties of the décollement zone (DZ) and protodécollement zone (PDZ) under the northern Barbados accretionary prism. Significant spatial variations of physical properties were observed in the PDZ seaward of the thrust front from the inversion data. The density generally increases southward with a few localized low‐density patches. A lower density commonly corresponds to a thicker PDZ, suggesting that the paleomorphology may at least partially control the variations of the physical properties. Similar low‐density patches were also found in the DZ. These features may be inherited from those of the PDZ and enhanced after subduction through localized arrested consolidation. Under the prism toe, the density of the DZ increases landward. This trend may mainly result from shear‐induced consolidation of the DZ but may also be related to landward increasing tectonic loading. Significant north–south differences in density and, thus, porosity and strength of the PDZ, are observed and these differences may continue into the DZ. A stronger DZ is likely responsible for a larger prism taper observed in the southern area of the prism toe. The larger taper, thus more horizontal shortening, coupled with a thinner sediment sheet above the PDZ in the southern area, may cause a relative retreat of the thrust front and a pronounced change in strike of the sequence thrusts south of seismic Line 690. The north–south differences may ultimately have originated in the approach of a structurally higher segment of the Tiburon Rise. The Tiburon Rise affects regional morphology and, thus, it controls the sedimentation and physical properties of the PDZ. It may also control sediment accumulation above the PDZ. Therefore, the sedimentational change induced by the structural high of the Tiburon Rise, in turn, resulted in structural change of the prism in the southern area.