Porous and highly dispersible voriconazole dry powders produced by spray freeze drying for pulmonary delivery with efficient lung deposition

Liao, Qiuying; Yip, Long; Chow, Michael Y.T.; Chow, Shing Fung; Chan, Hak‐Kim; Kwok, Philip Chi Lip; Lam, Jenny K.W.

doi:10.1016/j.ijpharm.2019.01.057

Cited by 50 publications

(24 citation statements)

References 44 publications

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“…Spray freeze drying (SFD) is an advanced technology for the production of LPP in pulmonary drug delivery with high production yields and being especially suitable for thermally sensitive materials ( Hadiwinoto et al, 2018 ; Liao et al, 2019 ). Three subprocesses are involved: (i) Atomization; the prepared drug solution is atomized quickly into a refrigerant media assisted by an atomization gas.…”

Section: Production Strategies Of Porous Particles Using Powder Technologymentioning

confidence: 99%

“… Use of spray freeze drying technology for the production of porous particles: (A) Scheme of the production method, and (B) image of inhaled voriconazole formulation prepared by this technology (B) . SEM picture adapted from Liao et al (2019) with permission. …”

Section: Production Strategies Of Porous Particles Using Powder Technologymentioning

confidence: 99%

“…The porous structure of the particles obtained by SFD not only can satisfy aerodynamic deposition demands, but also can improve the apparent solubility of the formulations ( Hastedt et al, 2016 ; Liao et al, 2019 ). Voriconazole-loaded LPP were successfully prepared using SFD for the treatment of pulmonary aspergillosis ( Liao et al, 2019 ). Voriconazole in the LPP-based formulation was immediately released in the medium of the dissolution test, whereas raw voriconazole required 2 h to completely dissolve.…”

Section: Production Strategies Of Porous Particles Using Powder Technologymentioning

confidence: 99%

See 2 more Smart Citations

A Pathway From Porous Particle Technology Toward Tailoring Aerogels for Pulmonary Drug Administration

Duong

López‐Iglesias

Szewczyk

et al. 2021

Front. Bioeng. Biotechnol.

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Section: Production Strategies Of Porous Particles Using Powder Technologymentioning

confidence: 99%

Section: Production Strategies Of Porous Particles Using Powder Technologymentioning

confidence: 99%

Section: Production Strategies Of Porous Particles Using Powder Technologymentioning

confidence: 99%

See 1 more Smart Citation

A Pathway From Porous Particle Technology Toward Tailoring Aerogels for Pulmonary Drug Administration

Duong

López‐Iglesias

Szewczyk

et al. 2021

Front. Bioeng. Biotechnol.

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“…The concentrations of VRC and TAR in the solubility and dissolution study were examined using an HPLC system equipped with a diode array detector (Agilent 1200 series, Agilent Technologies, Wilmington, DE, USA) and an Agilent Zorbax Eclipse Plus C18 column (5 µm, 250 mm × 4.6 mm, Agilent Technologies, Wilmington, DE, USA) in isocratic conditions. For VRC, the mobile phase consisted of a mixture of acetonitrile and 0.5% formic acid solution (50:50 v/v), as reported by Liao et al [29]. For TAR, a mobile phase made up of 50 mM phosphate buffer (pH = 2.2 adjusted with phosphoric acid) was used.…”

Section: High Performance Liquid Chromatography (Hplc)mentioning

confidence: 99%

Effects of the Glass-Forming Ability and Annealing Conditions on Cocrystallization Behaviors via Rapid Solvent Removal: A Case Study of Voriconazole

et al. 2020

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The kinetic entrapment of molecules in an amorphous phase is a common obstacle to cocrystal screening using rapid solvent removal, especially for drugs with a moderate or high glass-forming ability (GFA). The aim of this study was to elucidate the effects of the coformer’s GFA and annealing conditions on the nature of amorphous phase transformation to the cocrystal counterpart. Attempts were made to cocrystallize voriconazole (VRC) with four structural analogues, namely fumaric acid (FUM), tartaric acid (TAR), malic acid (MAL), and maleic acid (MAE). The overall GFA of VRC binary systems increased with decreasing glass transition temperatures (Tgs) of these diacids, which appeared as a critical parameter for predicting the cocrystallization propensity such that a high-Tg coformer is more desirable. A new 1:1 VRC-TAR cocrystal was successfully produced via a supercooled-mediated re-cocrystallization process, and characterized by PXRD, DSC, and FTIR. The cocrystal purity against the annealing temperature displayed a bell-shaped curve, with a threshold at 40 °C. The isothermal phase purity improved with annealing and adhered to the Kolmogorov–Johnson–Mehl–Avrami kinetics. The superior dissolution behavior of the VRC-TAR cocrystal could minimize VRC precipitation upon gastric emptying. This study offers a simple but useful guide for efficient cocrystal screening based on the Tg of structurally similar coformers, annealing temperature, and time.

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“…Over the years, alternative methods to produce aerosols, such as co-spray drying, solvent evaporation, and spray-freeze drying (SFD) techniques were evolved. SFD is an amalgamation of spray freezing and freezedrying process [20]. The advantage with spray dry, i.e.…”

Section: Introductionmentioning

confidence: 99%

Aerosol Performance of Beta-carotene Supplementation Prepared by Spray and Spray-Freeze Drying

Lavanya

Deotale

Moses

et al. 2020

IRJPAC

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The goal of the present work is to find a suitable method for developing β-carotene aerosols by varying core (active material) to wall (excipient) ratios (1:10, 1:25, and 1:50). For this, spray freeze drying (SFD) and spray drying (SD) techniques were adopted to develop aerosols. The results revealed that aerosols from SFD had low density and free-flowing behavior; whereas, SD samples were cohesive. SFD aerosols were porous and SD samples had smooth structures, with sizes of 8.3 to 9.3 and 9.3 to 9.6 µm, respectively. All formulations exhibited good mass median aerodynamic diameter (MMADt) of 3.75 to 6.96 µm and % emitted dosage was found higher in SFD aerosols (around 57 to 60%). Release of β-carotene through the in-vitro study was found higher in SFD samples and controlled release was observed in 1:50 formulation. In 12 h release, around 64% and 74% contents were released from SD and SFD aerosol samples, respectively. Particle density, size, and morphology strongly affect particle deposition in the lungs’ and this approach can be conveniently scale-up for pulmonary supplementation of food bioactive compounds.

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Porous and highly dispersible voriconazole dry powders produced by spray freeze drying for pulmonary delivery with efficient lung deposition

Cited by 50 publications

References 44 publications

A Pathway From Porous Particle Technology Toward Tailoring Aerogels for Pulmonary Drug Administration

A Pathway From Porous Particle Technology Toward Tailoring Aerogels for Pulmonary Drug Administration

Effects of the Glass-Forming Ability and Annealing Conditions on Cocrystallization Behaviors via Rapid Solvent Removal: A Case Study of Voriconazole

Aerosol Performance of Beta-carotene Supplementation Prepared by Spray and Spray-Freeze Drying

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