Porous core/sheath composite nanofibers fabricated by coaxial electrospinning as a potential mat for drug release system

Critical attributes of nanofibers: Preparation, drug loading, and tissue regeneration

“…Basic science in tissue engineering and regenerative medicine aims to investigate and understand the deposition, growth, and remodeling of tissues by exploiting the knowledge and experiences from a range of disciplines (Nguyen et al, 2012;Xue et al, 2014).…”

A Review of Injectable and Implantable Biomaterials for Treatment and Repair of Soft Tissues in Wound Healing

“…Fibers can be collected on a stationary collector for nonwoven fiber structure or on a rotating mandrel for aligned fiber structure [62]. Fibers can be produced by a coaxial or even triaxial nozzle to enable the core-shell structure [63,64]. Others demonstrated the possibility of pharmaceutical scaleup during the production of fiber mesh [65].…”

Incorporating small molecules or biologics into nanofibers for optimized drug release: A review

“…The solubility of the carrier and the availability of the drug to the dissolution medium can be tailored via coaxial electrospinning. The drug release rate was found to increase with an increasing core flow rate due to the presence of a high amount of water-soluble polymer (e.g., PEG) in the cores of the tested fibres (Nguyen et al, 2012) when an insoluble polymer (e.g., PLA) was applied as the sheath fluid. In addition to the use of carriers of different solubilities, the drug release rate can be controlled through the incorporation of enzymatically degradable polymers.…”