A Review of Injectable and Implantable Biomaterials for Treatment and Repair of Soft Tissues in Wound Healing

Chou, Shih-Feng; Gunaseelan, Simi; Kiellani, Mhd Hussam Hijazi; Thottempudi, Venkata Vamsi Krishna; Neuenschwander, Pierre F.; Nie, Huarong

doi:10.1155/2017/6341710

Cited by 14 publications

(10 citation statements)

References 102 publications

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“…Synthetic polymers that are biodegradable and biocompatible have been widely used in electrospinning for wound healing purposes. They can be blended with other synthetic or natural polymers to provide sustained release of drugs [ 2 , 61 ]. These polymers can be separated into water soluble and insoluble polymers ( Table 2 ).…”

Section: Electrospun Fibersmentioning

confidence: 99%

Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery in Wound Healing Applications

et al. 2018

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Wound healing is a complex tissue regeneration process that promotes the growth of new tissue to provide the body with the necessary barrier from the outside environment. In the class of non-healing wounds, diabetic wounds, and ulcers, dressing materials that are available clinically (e.g., gels and creams) have demonstrated only a slow improvement with current available technologies. Among all available current technologies, electrospun fibers exhibit several characteristics that may provide novel replacement dressing materials for the above-mentioned wounds. Therefore, in this review, we focus on recent achievements in electrospun drug-eluting fibers for wound healing applications. In particular, we review drug release, including small molecule drugs, proteins and peptides, and gene vectors from electrospun fibers with respect to wound healing. Furthermore, we provide an overview on multifunctional dressing materials based on electrospun fibers, including those that are capable of achieving wound debridement and wound healing simultaneously as well as multi-drugs loading/types suitable for various stages of the healing process. Our review provides important and sufficient information to inform the field in development of fiber-based dressing materials for clinical treatment of non-healing wounds.

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Section: Electrospun Fibersmentioning

confidence: 99%

Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery in Wound Healing Applications

et al. 2018

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“…Fibers that were electrospun from polymeric solutions have received great interest in the recent years. Owing to the high surface area to volume ratio, electrospun fibers exhibit potential applications in tissue engineering scaffolds [ 144 ], drug delivery carriers [ 145 ], and biomedical devices [ 146 ]. In addition, fiber surfaces can be decorated with functional macromolecules to improve characteristics in cell signaling.…”

Section: Nanostructured Fiber Surfacesmentioning

confidence: 99%

Nanostructure-Enabled and Macromolecule-Grafted Surfaces for Biomedical Applications

et al. 2018

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Advances in nanotechnology and nanomaterials have enabled the development of functional biomaterials with surface properties that reduce the rate of the device rejection in injectable and implantable biomaterials. In addition, the surface of biomaterials can be functionalized with macromolecules for stimuli-responsive purposes to improve the efficacy and effectiveness in drug release applications. Furthermore, macromolecule-grafted surfaces exhibit a hierarchical nanostructure that mimics nanotextured surfaces for the promotion of cellular responses in tissue engineering. Owing to these unique properties, this review focuses on the grafting of macromolecules on the surfaces of various biomaterials (e.g., films, fibers, hydrogels, and etc.) to create nanostructure-enabled and macromolecule-grafted surfaces for biomedical applications, such as thrombosis prevention and wound healing. The macromolecule-modified surfaces can be treated as a functional device that either passively inhibits adverse effects from injectable and implantable devices or actively delivers biological agents that are locally based on proper stimulation. In this review, several methods are discussed to enable the surface of biomaterials to be used for further grafting of macromolecules. In addition, we review surface-modified films (coatings) and fibers with respect to several biomedical applications. Our review provides a scientific update on the current achievements and future trends of nanostructure-enabled and macromolecule-grafted surfaces in biomedical applications.

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“…The improvement of dressings using nanotechnology has been inspired by the lack of adequate physicochemical properties and specific biological responses of classical materials for wound treatment [31]. Nanotechnology consists of manipulating materials at nanoscale levels and is widely employed in various fields of medicine, engineering, and electronics [32]. It can be a strategy to promote wound healing by intervening in the healing phases [31].…”

Section: Introductionmentioning

confidence: 99%

Nanotechnology Development for Formulating Essential Oils in Wound Dressing Materials to Promote the Wound-Healing Process: A Review

Luca¹,

Pedram

Moeini

et al. 2021

Applied Sciences

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Wound healing refers to the replacement of damaged tissue through strongly coordinated cellular events. The patient’s condition and different types of wounds complicate the already intricate healing process. Conventional wound dressing materials seem to be insufficient to facilitate and support this mechanism. Nanotechnology could provide the physicochemical properties and specific biological responses needed to promote the healing process. For nanoparticulate dressing design, growing interest has focused on natural biopolymers due to their biocompatibility and good adaptability to technological needs. Polysaccharides are the most common natural biopolymers used for wound-healing materials. In particular, alginate and chitosan polymers exhibit intrinsic antibacterial and anti-inflammatory effects, useful for guaranteeing efficient treatment. Recent studies highlight that several natural plant-derived molecules can influence healing stages. In particular, essential oils show excellent antibacterial, antifungal, antioxidant, and anti-inflammatory properties that can be amplified by combining them with nanotechnological strategies. This review summarizes recent studies concerning essential oils as active secondary compounds in polysaccharide-based wound dressings.

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A Review of Injectable and Implantable Biomaterials for Treatment and Repair of Soft Tissues in Wound Healing

Cited by 14 publications

References 102 publications

Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery in Wound Healing Applications

Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery in Wound Healing Applications

Nanostructure-Enabled and Macromolecule-Grafted Surfaces for Biomedical Applications

Nanotechnology Development for Formulating Essential Oils in Wound Dressing Materials to Promote the Wound-Healing Process: A Review

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