Porous hydroxyapatite ceramics by ice templating: Freezing characteristics and mechanical properties

Zhao, Kun; Tang, Yufei; Qin, Y.S.; Wei, Junqi

doi:10.1016/j.ceramint.2010.10.003

Cited by 51 publications

(29 citation statements)

References 22 publications

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“…The synthesis of HA and these apatite-like materials has attracted great interest in recent decades. Nowadays, the composites of synthetic HA and apatite-like materials with biodegradable polymer are considered to be promising candidates as grafts and scaffolds for hard tissue engineering [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of selenite substituted hydroxyapatite

Wang

Zhou

et al. 2013

Materials Science and Engineering: C

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Section: Introductionmentioning

confidence: 99%

Preparation and characterization of selenite substituted hydroxyapatite

Wang

Zhou

et al. 2013

Materials Science and Engineering: C

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“…Lithography was used to print a polymeric material, followed by packing with HA and sintering [418]. Both hot pressing [267,268] and ice templating [419,785] techniques might be applied as well. Besides, an HA suspension can be cast into a porous CaCO 3 skeleton, which is then dissolved, leaving a porous network [410].…”

Section: Porositymentioning

confidence: 99%

Medical Application of Calcium Orthophosphate Bioceramics

Dorozhkin¹

2011

BIO

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In the late 1960's, a strong interest was raised in biomedical applications of ceramic materials (named bioceramics a little bit later). Bioceramics was initially used as reasonable alternatives to metals in order to increase their biocompatibility. However, within a short period, it has grown into a diverse class of biomaterials, presently including three essential types: relatively bioinert, bioactive (or surface reactive) and bioresorbable bioceramics. This review is limited to bioceramics prepared from calcium orthophosphates only, which belong to the categories of bioactive and bioresorbable compounds. There have been a number of important advances in this field during the past 30 -40 years. The research was shifted from an initial study on the develop-ment of bioinert bioceramics towards bioactive and bioresorbable bioceramics, and these different types of calcium orthophosphate bioceramics can be tuned through the structural and compositional control. At the turn of the millennium, a new concept of calcium orthophosphate bioceramics has been developed to promote a regeneration of bones. Current biomedical applications of calcium orthophosphate bioceramics include artificial replacements for hips, knees, teeth, tendons and ligaments, as well as repair for periodontal disease, maxillofacial reconstruction, augmenttation and stabilization of the jawbone, spinal fusion and bone fillers after tumor surgery. Potential future applications of calcium orthophosphate bioceramics are demonstrated in drug delivery systems, effective carriers of growth factors, bioactive peptides and/or various types of cells for tissue engineering purposes.

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“…Having a chemical formula (Ca 10 (PO 4 ) 6 (OH) 2 ), stoichiometric HAp has a structure very similar to that of natural bone [24,26,34,[43][44][45]. For this reason, synthetic CaP materials including HAp are FDA-approved and were among the most investigated materials for scaffold composition for over three decades [46][47][48][49][50][51]. CaPs differ from one another in origin, composition, morphology, and physicochemical properties.…”

Section: Bioceramics For Sbd Repairmentioning

confidence: 99%

“…HAp [23,44,46,51,[59][60][61][62] is the most commonly used ceramic biomaterial in orthopedic applications because of its biocompatibility [63][64][65]. HAp scaffolds stimulate cell attachment, growth, and differentiation [23,48,66], even though they degrade at a very slow rate [67]. -tricalcium phosphate ( -TCP) is the second most widely used CaP ceramic in bioengineering, and its alkaline nature makes it a good candidate for hybrid scaffolds to counteract the acidity resulting from polymer breakdown [8,27,46,62,68].…”

Section: Current Bioceramics Being Investigatedmentioning

confidence: 99%

Development of Composite Scaffolds for Load Bearing Segmental Bone Defects

Pilia¹,

Guda²,

Appleford³

2013

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The need for a suitable tissue-engineered scaffold that can be used to heal load-bearing segmental bone defects (SBDs) is both immediate and increasing. During the past 30 years, various ceramic and polymer scaffolds have been investigated for this application. More recently, while composite scaffolds built using a combination of ceramics and polymeric materials are being investigated in a greater number, very few products have progressed from laboratory benchtop studies to preclinical testing in animals. This review is based on an exhaustive literature search of various composite scaffolds designed to serve as bone regenerative therapies. We analyzed the benefits and drawbacks of different composite scaffold manufacturing techniques, the properties of commonly used ceramics and polymers, and the properties of currently investigated synthetic composite grafts. To follow, a comprehensive review of in vivo models used to test composite scaffolds in SBDs is detailed to serve as a guide to design appropriate translational studies and to identify the challenges that need to be overcome in scaffold design for successful translation. This includes selecting the animal type, determining the anatomical location within the animals, choosing the correct study duration, and finally, an overview of scaffold performance assessment.

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Porous hydroxyapatite ceramics by ice templating: Freezing characteristics and mechanical properties

Cited by 51 publications

References 22 publications

Preparation and characterization of selenite substituted hydroxyapatite

Preparation and characterization of selenite substituted hydroxyapatite

Medical Application of Calcium Orthophosphate Bioceramics

Development of Composite Scaffolds for Load Bearing Segmental Bone Defects

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