Porous magnesium/PLGA composite scaffolds for enhanced bone regeneration following tooth extraction

Brown, Andrew J.; Zaky, Samer H.; Ray, Herbert L.; Sfeir, Charles

doi:10.1016/j.actbio.2014.09.008

Cited by 180 publications

(108 citation statements)

References 45 publications

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“…The total porosity, P total (the total pore volume divided by the volume of the scaffold), can be Where ρ s is the density of metallic Zn (7.14 g/cm 3 ).…”

Section: Morphology and Structural Characterization Of Porous Zn Scafmentioning

confidence: 99%

“…Inasmuch as magnesium is biodegradable and has a good biocompatibility as well as excellent mechanical properties [1], biodegradable metal scaffolds are mainly made of magnesium and its alloys (such as Mg-Zn, Mg-Y, Mg-Mn, Mg-Al-Zn, Mg-Zn-Mn, Mg-Zn-Mn-Ca) currently [2][3][4][5][6][7][8]. However, these porous scaffolds made of magnesium and its alloys corrode too rapidly in corrosive media because of the high chemical activity of magnesium and large surface areas possessed by the scaffolds.…”

Section: Introductionmentioning

confidence: 99%

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Mechanical properties and in vitro biodegradation of newly developed porous Zn scaffolds for biomedical applications

et al. 2016

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“…The total porosity, P total (the total pore volume divided by the volume of the scaffold), can be Where ρ s is the density of metallic Zn (7.14 g/cm 3 ).…”

Section: Morphology and Structural Characterization Of Porous Zn Scafmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mechanical properties and in vitro biodegradation of newly developed porous Zn scaffolds for biomedical applications

et al. 2016

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“…[18][19][20] Magnesium degrades without toxicity in the body and increases osteoconductivity in vivo, enabling complete bone regeneration at the implant site. 21 In addition, the proliferation and gene expression of osteogenic markers have been shown to be increased in cells exposed to magnesium in vitro. 22 Magnesium silicate (MS) bioceramics have been used in bone tissue engineering because of their osteogenic properties, significant bone-like apatite formation ability, and excellent bioactivity.…”

Section: Introductionmentioning

confidence: 99%

“…The bottle containing scaffold with PBS solution was placed in a shaking water bath (37°C, 80 rpm). The specimens were taken out at the designated point of times (1,3,7,14,21, and 28 days). After wiping off the surface moisture, the specimens were weighed while wet.…”

mentioning

confidence: 99%

Enhanced biocompatibility and osteogenic potential of mesoporous magnesium silicate/polycaprolactone/wheat protein composite scaffolds

Kang

Wei

Shin

et al. 2018

IJN

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Background Successful bone tissue engineering using scaffolds is primarily dependent on the properties of the scaffold, including biocompatibility, highly interconnected porosity, and mechanical integrity. Methods In this study, we propose new composite scaffolds consisting of mesoporous magnesium silicate (m_MS), polycaprolactone (PCL), and wheat protein (WP) manufactured by a rapid prototyping technique to provide a micro/macro porous structure. Experimental groups were set based on the component ratio: (1) WP0% (m_MS:PCL:WP =30:70:0 weight per weight; w/w); (2) WP15% (m_MS:PCL:WP =30:55:15 w/w); (3) WP30% (m_MS:PCL:WP =30:40:30 w/w). Results Evaluation of the properties of fabricated scaffolds indicated that increasing the amount of WP improved the surface hydrophilicity and biodegradability of m_MS/PCL/WP composites, while reducing the mechanical strength. Moreover, experiments were performed to confirm the biocompatibility and osteogenic differentiation of human mesenchymal stem cells (MSCs) according to the component ratio of the scaffold. The results confirmed that the content of WP affects proliferation and osteogenic differentiation of MSCs. Based on the last day of the experiment, ie, the 14th day, the proliferation based on the amount of DNA was the best in the WP30% group, but all of the markers measured by PCR were the most expressed in the WP15% group. Conclusion These results suggest that the m_MS/PCL/WP composite is a promising candidate for use as a scaffold in cell-based bone regeneration.

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“…The elastic modulus of magnesium (45 GPa) is close to that of cortical bone , which will minimize stress shielding effects [10,11]. Among all magnesium materials, the porous magnesium is a research focus for its relatively low elastic modulus and good bone conduction ability [12][13][14].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Porous magnesium loaded with gentamicin sulphate and in vitro release behavior

Jiang

Wang

et al. 2016

Materials Science and Engineering: C

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Porous magnesium/PLGA composite scaffolds for enhanced bone regeneration following tooth extraction

Cited by 180 publications

References 45 publications

Mechanical properties and in vitro biodegradation of newly developed porous Zn scaffolds for biomedical applications

Mechanical properties and in vitro biodegradation of newly developed porous Zn scaffolds for biomedical applications

Enhanced biocompatibility and osteogenic potential of mesoporous magnesium silicate/polycaprolactone/wheat protein composite scaffolds

Porous magnesium loaded with gentamicin sulphate and in vitro release behavior

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