Porous materials applied to biomarker sensing in exhaled breath for monitoring and detecting non-invasive pathologies

André, Laurie; Desbois, Nicolas; Gros, Claude P.; Brandès, Stéphane

doi:10.1039/d0dt02511a

Cited by 17 publications

(11 citation statements)

References 109 publications

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“…Efficient detection of volatile organic compounds (VOCs) in human breath or environmental surroundings is significant for healthcare , and ecology . The use of 2D materials has been widely explored to detect VOCs and gases, where the intrinsic electrical conductivity , (charge transfer and band gap value) of the materials was considered.…”

Section: Results and Discussionmentioning

confidence: 99%

Edge-Hydrogenated Germanene by Electrochemical Decalcification-Exfoliation of CaGe₂: Germanene-Enabled Vapor Sensor

2021

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Two-dimensional germanene has been recently explored for applications in sensing, catalysis, and energy storage. The potential of this van der Waals material lies in its optoelectronic and chemical properties. However, pure free-standing germanene cannot be found in nature, and the synthesis methods are hindering the potentially fascinating properties of germanene. Herein, we report a single-step synthesis of few-layer germanene by electrochemical exfoliation in a nonaqueous environment. As a result of simultaneous decalcification and intercalation of the electrolyte’s active ions, we achieved low-level hydrogenation of germanene that occurs at the edges of the material. The obtained edge-hydrogenated germanene flakes have a lateral size of several micrometers and possess a cubic structure. We have pioneered the potential application of edge-hydrogenated germanene for vapor sensing and demonstrated its specific sensitivity to methanol and ethanol. Furthermore, we have shown a selective behavior of the germanene-based sensor that appears to increase the electrical resistance in the vapors where methanol prevails. We anticipate that these results can provide an approach for emerging layered materials with the potential utility in advanced gas sensing.

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Section: Results and Discussionmentioning

confidence: 99%

Edge-Hydrogenated Germanene by Electrochemical Decalcification-Exfoliation of CaGe₂: Germanene-Enabled Vapor Sensor

2021

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“…Hedge-Ge-enabled vapor sensor. Efficient detection of volatile organic compounds in human breath or environmental surroundings is significant for healthcare, 56,57 and ecology. 58 The use of 2D materials has been widely explored for the detection of VOCs and gases, 59 where the intrinsic electrical conductivity 60,61 (charge transfer, bandgap value) of the materials was considered.…”

Section: Resultsmentioning

confidence: 99%

Edge-Hydrogenated Germanene by Electrochemical Decalcification-Exfoliation of CaGe2: Germanene-Enabled Vapor Sensor

Kovalska

Antonatos²,

Sofer³

2021

Preprint

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<p><a>Two-dimensional germanene has been recently explored for applications in sensing, catalysis, and energy storage. The potential of this material lies on its graphene-like optoelectronic and chemical properties. However, pure free-standing germanene cannot be found in nature and the synthetic methods are hindering the potentially fascinating properties of germanene. </a>Herein, <a>we report for the first time a single-step synthesis of few-layer germanene by electrochemical exfoliation in non-aqueous environment. As a result of simultaneous decalcification and intercalation of the electrolyte’s active ions, we achieved a low-level hydrogenation of germanene that occurs at the edges of the material. The obtained edge-hydrogenated germanene flakes have a lateral size of several micrometers which possess a cubic structure. We have pioneered the potential application of edge-hydrogenated germanene for vapor sensing and demonstrated its specific sensitivity to methanol and ethanol. We have shown a selective behavior of the germanene-based sensor that appears to increase the electrical resistance in the vapors where methanol prevails. We anticipate that these results can provide a new approach for emerging layered materials with the potential utility in advanced gas sensing.</a></p>

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“…Due to these features, MOFs can exhibit a high selectivity toward a desired target gas. MOFs have been used as active sensing materials to detect vapors and VOCs, [13][14][15][16][17][18][19] water vapor, 20,21 CO 2 , 9,22,23 O 2 , 24 and sulfur containing gases 25,26 (SO 2 and H 2 S). A priori, MOFs are suitable candidates for active sensing material owing to their tunable selectivity toward a target gas, ability to be coated onto miniature sensors, and ability to function under both room and elevated temperatures.…”

Section: Introductionmentioning

confidence: 99%

Material Screening for Gas Sensing using an Electronic Nose: Gas Sorption Thermodynamic and Kinetic Considerations

Rajagopalan¹,

Petit²

2021

Preprint

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To detect multiple gases in a mixture, one must employ an electronic nose or sensor array, composed of several materials as a single material cannot resolve all the gases in a mixture accurately. Given the many candidate materials, choosing the right combination of materials to be used in an array is a challenging task. In a sensor whose sensing mechanism depends on a change in mass upon gas adsorption, both the equilibrium and kinetic characteristics of the gas-material system dictate the performance of the array. The overarching goal of this work is two-fold. First, we aim to highlight the impact of thermodynamic characteristics of gas-material combination on array performance and to develop a graphical approach to rapidly screen materials. Second, we aim to highlight the need to incorporate the gas sorption kinetic characteristics to provide an accurate picture of the performance of a sensor array. To address these goals, we have developed a computational test bench that incorporates a sensor model and a gas composition estimator. To provide a generic study, we have chosen, as candidate materials, hypothetical materials that exhibit equilibrium characteristics similar to metal organic frameworks (MOFs). Our computational studies led to key learnings, namely: (1) exploit the shape of the sensor response as a function of gas composition for material screening purposes for gravimetric arrays; (2) incorporate both equilibrium and kinetics for gas composition estimation in a dynamic system; and (3) engineer the array by accounting for the kinetics of the materials, the feed gas flow rate, and the size of the device.

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Porous materials applied to biomarker sensing in exhaled breath for monitoring and detecting non-invasive pathologies

Abstract: The quantification of specific gases among thousand of VOCs (Volatile Organic Compounds) present in the human breath at the ppm/ppb level can be used to evidence the presence of diseases...

Cited by 17 publications

References 109 publications

Edge-Hydrogenated Germanene by Electrochemical Decalcification-Exfoliation of CaGe₂: Germanene-Enabled Vapor Sensor

Edge-Hydrogenated Germanene by Electrochemical Decalcification-Exfoliation of CaGe₂: Germanene-Enabled Vapor Sensor

Edge-Hydrogenated Germanene by Electrochemical Decalcification-Exfoliation of CaGe2: Germanene-Enabled Vapor Sensor

Material Screening for Gas Sensing using an Electronic Nose: Gas Sorption Thermodynamic and Kinetic Considerations

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