Porous scaffolds with enzyme-responsive Kartogenin release for recruiting stem cells and promoting cartilage regeneration

Lin, Feng Huei; Li, Pengqiang; Yan, Shifeng; Zhang, Kunxi; Cui, Wenguo; Yin, Jingbo

doi:10.1016/j.cej.2022.137454

Cited by 11 publications

(1 citation statement)

References 56 publications

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“…After screening 22,000 structurally diverse and heterocyclic drug-like small molecules, it was found that KGN, without any toxicity, could obviously improve the chondrocyte differentiation of MSCs in a dose-dependent manner [ 31 ]. Moreover, KGN also has longer stability and half-life than those of the biological protein growth factors in the application of cartilage tissue engineering [ 32 , 33 , 34 , 35 , 36 ]. In addition, the lymphatic system can rapidly clear the pure KGN injected via the articular cavity, and this intra-articular injection can also cause organ damage due to leakage into the circulatory system.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Injectable Kartogenin-Conjugated Composite Hydrogel with a Sustained Drug Release for Cartilage Repair

Liu

Weng

et al. 2023

Pharmaceutics

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Cartilage tissue engineering has attracted great attention in defect repair and regeneration. The utilization of bioactive scaffolds to effectively regulate the phenotype and proliferation of chondrocytes has become an elemental means for cartilage tissue regeneration. On account of the simultaneous requirement of mechanical and biological performances for tissue-engineered scaffolds, in this work we prepared a naturally derived hydrogel composed of a bioactive kartogenin (KGN)-linked chitosan (CS-KGN) and an aldehyde-modified oxidized alginate (OSA) via the highly efficient Schiff base reaction and multifarious physical interactions in mild conditions. On the basis of the rigid backbones and excellent biocompatibility of these two natural polysaccharides, the composite hydrogel demonstrated favorable morphology, easy injectability, good mechanical strength and tissue adhesiveness, low swelling ratio, long-term sustainable KGN release, and facilitated bone marrow mesenchymal stem cell activity, which could simultaneously provide the mechanical and biological supports to promote chondrogenic differentiation and repair the articular cartilage defects. Therefore, we believe this work can offer a designable consideration and potential alternative candidate for cartilage and other soft tissue implants.

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Section: Introductionmentioning

confidence: 99%

Fabrication of Injectable Kartogenin-Conjugated Composite Hydrogel with a Sustained Drug Release for Cartilage Repair

Liu

Weng

et al. 2023

Pharmaceutics

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Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration

Yuan,

Zhu,

Yang

et al. 2024

Advanced Materials

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The repair and functional reconstruction of bone defects resulting from severe trauma, surgical resection, degenerative disease, and congenital malformation pose significant clinical challenges. Bone tissue engineering (BTE) holds immense potential in treating these severe bone defects, without incurring prevalent complications associated with conventional autologous or allogeneic bone grafts. 3D printing technology enables control over architectural structures at multiple length scales and has been extensively employed to process biomimetic scaffolds for BTE. In contrast to inert and functional bone grafts, next‐generation smart scaffolds possess a remarkable ability to mimic the dynamic nature of native extracellular matrix (ECM), thereby facilitating bone repair and regeneration. Additionally, they can generate tailored and controllable therapeutic effects, such as antibacterial or antitumor properties, in response to exogenous and/or endogenous stimuli. This review provides a comprehensive assessment of the progress of 3D‐printed smart scaffolds for BTE applications. It begins with an introduction to bone physiology, followed by an overview of 3D printing technologies utilized for smart scaffolds. Notable advances in various stimuli‐responsive strategies, therapeutic efficacy, and applications of 3D‐printed smart scaffolds are discussed. Finally, the review highlights the existing challenges in the development and clinical implementation of smart scaffolds, as well as emerging technologies in this field.

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Stimuli-responsive hydrogels: cutting-edge platforms for cartilage tissue engineering

El-Husseiny,

Mady,

Yoshida

et al. 2024

Cartilage Tissue and Knee Joint Biomechanics

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Porous scaffolds with enzyme-responsive Kartogenin release for recruiting stem cells and promoting cartilage regeneration

Cited by 11 publications

References 56 publications

Fabrication of Injectable Kartogenin-Conjugated Composite Hydrogel with a Sustained Drug Release for Cartilage Repair

Fabrication of Injectable Kartogenin-Conjugated Composite Hydrogel with a Sustained Drug Release for Cartilage Repair

Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration

Stimuli-responsive hydrogels: cutting-edge platforms for cartilage tissue engineering

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