Porous Silicon Application Survey

A novel approach for osteocalcin detection by competitive ELISA using porous silicon as a substrate

“…To date, PSi has gained popularity in a wide variety of areas including microelectronics, optics, optoelectronics, sensors, solar cells, catalysis, filtration, medical and therapeutic fields due to its particular structure and outstanding properties [1][2][3][4][5][6][7]. Of all these features, large surface to volume ratio (up to 600 m 2 /cm 3 ), high surface reactivity, controllable morphology and pore diameter, biocompatibility, biodegradability, and compatibility with the existing microelectronic and microfluidic technology suggest that PSi holds promise for biomedical applications such as in vivo imaging, tissue engineering, drug delivery, and especially sensing and molecular screening [1][2][3][4][8][9][10][11][12]. By using PSi in sensing application, the large surface area along with the high surface reactivity of this structure results in the high sensitivity and low detection limit.…”

“…By using PSi in sensing application, the large surface area along with the high surface reactivity of this structure results in the high sensitivity and low detection limit. However, the existence of exclusive properties such as visible luminescence at room temperature, porosity-and ambient-dependent refractive index, quantum confinement effect, and simple surface modification makes PSi a suitable transducer in a variety of detection methods such as electrical (conductance, resistance, capacitance, and so on), electrochemical (conductimetric, amperometric, impedimetric, and potentiometric), optical (reflectance, photoluminescence, fluorescence, and so on), and thermal (temperature change) methods [1][2][3][13][14][15].…”